Hedgehog signaling pathway: Epigenetic regulation and role in disease and cancer development

Sonidegib: mechanism of action, pharmacology, and clinical utility for advanced basal cell carcinomas

(2017) Sachin Jain et al.   OncoTargets and Therapy

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

Sonic Hedgehog Signaling in the Lung. From Development to Disease

(2015) Matthias C. Kugler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy

(2015) Silvia Pandolfi et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

MicroRNA-602 and MicroRNA-608 Regulate Sonic Hedgehog Expression via Target Sites in the Coding Region in Human Chondrocytes

(2015) Nahid Akhtar et al.   Arthritis & Rheumatology

Prediction of microRNA target genes using an efficient genetic algorithm-based decision tree

(2015) Behzad Rabiee-Ghahfarrokhi et al.   FEBS Open Bio

Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions

(2015) Dongsheng Gu et al.   Cancers

GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis

(2015) Ritesh K. Srivastava et al.   Oncotarget

Ptch2 mediates the Shh response in Ptch1-/- cells

(2014) A. C. Alfaro et al.   DEVELOPMENT

miR-212 promotes pancreatic cancer cell growth and invasion by targeting the hedgehog signaling pathway receptor patched-1

(2014) Chenchao Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma

(2014) E Petrova et al.   ONCOGENE

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

(2014) Pawel Niewiadomski et al.   Cell Reports

A Rapid Genome-wide MicroRNA Screen Identifies miR-14 as a Modulator of Hedgehog Signaling

(2014) Kevin Kim et al.   Cell Reports

Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds

(2014) Hyekyung Yang et al.   Cancer Medicine

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation

(2013) Amy L. Cherry et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

(2013) A. Jimeno et al.   CLINICAL CANCER RESEARCH

Hedgehog Signaling Pathway and Cancer Therapeutics: Progress to Date

(2013) Joshua M. Ruch et al.   DRUGS

Targeting Sonic Hedgehog Signaling by Compounds and Derivatives from Natural Products

(2013) Yu-Chuen Huang et al.   Evidence-based Complementary and Alternative Medicine

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

(2013) Elissaveta Petrova et al.   Nature Chemical Biology

Dissecting the chromatin interactome of microRNA genes

(2013) D. Chen et al.   NUCLEIC ACIDS RESEARCH

The effects of hepatitis C virus core protein on the expression of miR-122 in vitro

(2013) Sujuan Li et al.   Virology Journal

How is digit identity determined during limb development?

(2012) Takayuki Suzuki   DEVELOPMENT GROWTH & DIFFERENTIATION

Not lost in translation: stepwise regulation of microRNA targets

(2012) Maja M Janas et al.   EMBO JOURNAL

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growthin vitroandin vivo

(2012) Malin Wickström et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/β-catenin pathway

(2012) Jie Xu et al.   LIVER INTERNATIONAL

Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines

(2012) HAI-JI SUN et al.   Molecular Medicine Reports

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

(2012) J. Fombonne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand

(2012) Hanna Tukachinsky et al.   Cell Reports

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4

(2011) Ying-Jie Guan et al.   FASEB JOURNAL

Genital abnormalities in Pallister-Hall syndrome: Report of two patients and review of the literature

(2010) Yoko Narumi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

(2010) James Kim et al.   CANCER CELL

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

(2010) E. W. Humke et al.   GENES & DEVELOPMENT

Dual Function of UNC-51-like Kinase 3 (Ulk3) in the Sonic Hedgehog Signaling Pathway

(2010) Alla Maloverjan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

Molecular Therapy Targeting Sonic Hedgehog and Hepatocyte Growth Factor Signaling in a Mouse Model of Medulloblastoma

(2010) V. Coon et al.   MOLECULAR CANCER THERAPEUTICS

Review: Targeting the Hedgehog pathway in cancer

(2010) Sachin Gupta et al.   Therapeutic Advances in Medical Oncology

Genetics of basal cell carcinoma

(2009) Sally E De Zwaan et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Sufu recruits GSK3β for efficient processing of Gli3

(2009) Yoshiaki Kise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small RNAs in transcriptional gene silencing and genome defence

(2009) Danesh Moazed   NATURE

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Down-Regulation of Hedgehog-Interacting Protein through Genetic and Epigenetic Alterations in Human Hepatocellular Carcinoma

(2008) M. Tada et al.   CLINICAL CANCER RESEARCH

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

(2008) Jianjian Zhu et al.   DEVELOPMENTAL CELL

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

(2008) Elisabetta Ferretti et al.   EMBO JOURNAL

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Sonic hedgehog mutations identified in holoprosencephaly patients can act in a dominant negative manner

(2008) Samer Singh et al.   HUMAN GENETICS

miR-122, a paradigm for the role of microRNAs in the liver

(2008) Muriel Girard et al.   JOURNAL OF HEPATOLOGY

G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

(2008) Stacey K. Ogden et al.   NATURE

Nevoid basal cell carcinoma syndrome (Gorlin syndrome)

(2008) Lorenzo Lo Muzio   Orphanet Journal of Rare Diseases

MicroRNAs: Control and Loss of Control in Human Physiology and Disease

(2008) Min Li et al.   WORLD JOURNAL OF SURGERY