Hedgehog Signaling Pathway and Cancer Therapeutics: Progress to Date
Published 2013 View Full Article
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Title
Hedgehog Signaling Pathway and Cancer Therapeutics: Progress to Date
Authors
Keywords
Pancreatic Cancer, Gemcitabine, Medulloblastoma, Basal Cell Carcinoma, Primary Cilium
Journal
DRUGS
Volume 73, Issue 7, Pages 613-623
Publisher
Springer Nature
Online
2013-04-19
DOI
10.1007/s40265-013-0045-z
References
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Note: Only part of the references are listed.- A phase I study of IPI-926, a novel hedgehog pathway inhibitor, in patients (pts) with advanced or metastatic solid tumors.
- (2017) C. M. Rudin et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeting hedgehog in hematologic malignancy
- (2012) D. A. Irvine et al. BLOOD
- Molecular Pathways: The Hedgehog Signaling Pathway in Cancer
- (2012) R. McMillan et al. CLINICAL CANCER RESEARCH
- Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
- (2012) Rafael Rosell et al. LANCET ONCOLOGY
- Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome
- (2012) Jean Y. Tang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
- (2012) Aleksandar Sekulic et al. NEW ENGLAND JOURNAL OF MEDICINE
- The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
- (2012) M. Rajurkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibiting Hedgehog Pathway May Aid in Pancreatic Cancer Treatment
- (2012) Cancer Discovery
- Gli Proteins in Development and Disease
- (2011) Chi-chung Hui et al. Annual Review of Cell and Developmental Biology
- Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells
- (2011) T. Mazumdar et al. CANCER RESEARCH
- Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists
- (2011) C. Metcalfe et al. CANCER RESEARCH
- Polymeric Nanoparticle-Encapsulated Hedgehog Pathway Inhibitor HPI-1 (NanoHHI) Inhibits Systemic Metastases in an Orthotopic Model of Human Hepatocellular Carcinoma
- (2011) Yang Xu et al. CLINICAL CANCER RESEARCH
- Pharmacokinetic Dose-Scheduling Study of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor
- (2011) Hans Skvara et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
- (2011) Caicun Zhou et al. LANCET ONCOLOGY
- Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells
- (2010) T. Mazumdar et al. CANCER RESEARCH
- Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
- (2010) Gerrit J. P. Dijkgraaf et al. CANCER RESEARCH
- Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site
- (2010) Henry R. Maun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
- (2010) Elspeth M. Beauchamp et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hedgehog signaling maintains chemoresistance in myeloid leukemic cells
- (2010) K C S Queiroz et al. ONCOGENE
- Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
- (2010) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
- (2010) S. Buonamici et al. Science Translational Medicine
- Review: Targeting the Hedgehog pathway in cancer
- (2010) Sachin Gupta et al. Therapeutic Advances in Medical Oncology
- Paracrine Hedgehog Signaling in Cancer
- (2009) J.-W. Theunissen et al. CANCER RESEARCH
- Pancreatic Cancer and Precursor Pancreatic Intraepithelial Neoplasia Lesions Are Devoid of Primary Cilia
- (2009) E. S. Seeley et al. CANCER RESEARCH
- Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
- (2009) Frédéric Varnat et al. EMBO Molecular Medicine
- GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
- (2009) O. Nolan-Stevaux et al. GENES & DEVELOPMENT
- Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
- (2009) Chen Zhao et al. NATURE
- A small molecule that binds Hedgehog and blocks its signaling in human cells
- (2009) Benjamin Z Stanton et al. Nature Chemical Biology
- Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
- (2009) Charles M. Rudin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
- (2009) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma
- (2009) Tony S. Mok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
- (2009) J. M. Hyman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
- (2009) H. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
- (2009) R. L. Yauch et al. SCIENCE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation
- (2008) Christine Dierks et al. CANCER CELL
- Role of Hedgehog Signaling in Ovarian Cancer
- (2008) R. Bhattacharya et al. CLINICAL CANCER RESEARCH
- Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists
- (2008) Martin R. Tremblay et al. JOURNAL OF MEDICINAL CHEMISTRY
- Hedgehog-Induced Survival of B-Cell Chronic Lymphocytic Leukemia Cells in a Stromal Cell Microenvironment: A Potential New Therapeutic Target
- (2008) G. V. Hegde et al. MOLECULAR CANCER RESEARCH
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
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