Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis

Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis

(2015) Silvia von Karstedt et al.   CANCER CELL

Intersectin1-s, A multidomain adapter protein, Is essential for malignant glioma proliferation

(2015) Feng Gu et al.   GLIA

Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5

(2015) C. Bardita et al.   JOURNAL OF CELL SCIENCE

Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer

(2014) Ting Li et al.   Molecular Cancer

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3

(2014) A Archibald et al.   ONCOGENE

The Soft Agar Colony Formation Assay

(2014) Stanley Borowicz et al.   Jove-Journal of Visualized Experiments

Vinculin, cell mechanics and tumour cell invasion

(2013) Wolfgang H. Goldmann et al.   CELL BIOLOGY INTERNATIONAL

Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways

(2013) Michael Hunter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Novel p38 Mitogen-activated Protein Kinase/Elk-1 Transcription Factor-dependent Molecular Mechanism Underlying Abnormal Endothelial Cell Proliferation in Plexogenic Pulmonary Arterial Hypertension

(2013) Monal Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

(2013) A. Steffen et al.   JOURNAL OF CELL SCIENCE

Receptor Tyrosine Kinase Ubiquitylation Involves the Dynamic Regulation of Cbl-Spry2 by Intersectin 1 and the Shp2 Tyrosine Phosphatase

(2013) M. N. Okur et al.   MOLECULAR AND CELLULAR BIOLOGY

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

(2013) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

Adaptor Proteins Intersectin 1 and 2 Bind Similar Proline-Rich Ligands but Are Differentially Recognized by SH2 Domain-Containing Proteins

(2013) Olga Novokhatska et al.   PLoS One

In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs

(2012) Cristina Bardita et al.   APOPTOSIS

Human Intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation

(2012) Xiaofeng Ding et al.   BMB Reports

Intersectin 1 is required for neuroblastoma tumorigenesis

(2012) A Russo et al.   ONCOGENE

Paxillin and Hic-5 Interaction with Vinculin Is Differentially Regulated by Rac1 and RhoA

(2012) Nicholas O. Deakin et al.   PLoS One

An E3 ubiquitin ligase: c-Cbl

(2011) Fang-Yi Lo et al.   CANCER

Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb-Raf-1 Interaction as a Novel Target for Metastatic Disease

(2011) J. L. Johnson et al.   CANCER RESEARCH

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Seventh Edition of the Cancer Staging Manual and Stage Grouping of Lung Cancer

(2011) Omar Lababede et al.   CHEST

Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities

(2011) Chunhong Liu et al.   DEVELOPMENTAL NEUROSCIENCE

Cdc42 GTPase-activating protein (CdGAP) interacts with the SH3D domain of Intersectin through a novel basic-rich motif

(2011) Martin Primeau et al.   FEBS LETTERS

c-Cbl Ubiquitin Ligase Regulates Focal Adhesion Protein Turnover and Myofibril Degeneration Induced by Neutrophil Protease Cathepsin G

(2011) Khadija Rafiq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of intersectin1-s induced apoptosis of human glioblastoma cells

(2010) Yongjie Ma et al.   BRAIN RESEARCH

Adaptor Proteins as Targets for Cancer Prevention

(2010) D. Yee   Cancer Prevention Research

EPS8 upregulates FOXM1 expression, enhancing cell growth and motility

(2010) Huixin Wang et al.   CARCINOGENESIS

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

Intersectin multidomain adaptor proteins: Regulation of functional diversity

(2010) Liudmyla Tsyba et al.   GENE

Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies

(2010) Guy Lahat et al.   PLoS One

Intersectin-2L Regulates Caveola Endocytosis Secondary to Cdc42-mediated Actin Polymerization

(2009) Irene K. Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic significance of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in patients with breast cancer

(2009) Tom M. Ganten et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons

(2008) Liudmyla Tsyba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression

(2008) C. Chabu et al.   DEVELOPMENT

Grb2 signaling in cell motility and cancer

(2008) Alessio Giubellino et al.   EXPERT OPINION ON THERAPEUTIC TARGETS