Metabolic regulation of chromatin modifications and gene expression

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling

(2018) Rui Su et al.   CELL

Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity

(2018) Lydia W. S. Finley et al.   NATURE CELL BIOLOGY

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

(2018) Jingjing Chen et al.   NATURE GENETICS

A drive in SUVs: From development to disease

(2017) Vinay Kumar Rao et al.   Epigenetics

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

(2017) Sharanya Sivanand et al.   MOLECULAR CELL

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

(2017) Guillermo Burgos-Barragan et al.   NATURE

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

(2017) Michalis Agathocleous et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

Lactate dehydrogenase activity drives hair follicle stem cell activation

(2017) Aimee Flores et al.   NATURE CELL BIOLOGY

The impact of cellular metabolism on chromatin dynamics and epigenetics

(2017) Michael A. Reid et al.   NATURE CELL BIOLOGY

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

(2017) Andrew M Intlekofer et al.   Nature Chemical Biology

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

(2017) Oliver G McDonald et al.   NATURE GENETICS

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

(2017) Frank Lyko   NATURE REVIEWS GENETICS

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

(2017) Vinay Bulusu et al.   Cell Reports

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

(2016) Tara TeSlaa et al.   Cell Metabolism

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

(2016) In-Young Hwang et al.   Cell Metabolism

Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State

(2016) Wen Gu et al.   Cell Stem Cell

Metabolic control of methylation and acetylation

(2016) Xiaoyang Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self‐renewal and early development

(2016) Marianne Terndrup Pedersen et al.   EMBO JOURNAL

Building up the nucleus: nuclear organization in the establishment of totipotency and pluripotency during mammalian development

(2016) Máté Borsos et al.   GENES & DEVELOPMENT

Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells

(2016) Ferdinand von Meyenn et al.   MOLECULAR CELL

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

(2016) Filippos Kottakis et al.   NATURE

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

(2016) Min Pan et al.   NATURE CELL BIOLOGY

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Regulation of Histone Post-Translational Modifications

(2015) Jing Fan et al.   ACS Chemical Biology

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

(2015) William M. Oldham et al.   Cell Metabolism

Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors

(2015) David C. Montgomery et al.   CHEMISTRY & BIOLOGY

Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2

(2015) S. G. Dann et al.   EMBO JOURNAL

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

(2015) Tuomas Laukka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism

(2015) Shanshan Li et al.   MOLECULAR CELL

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

(2015) Henrik Sperber et al.   NATURE CELL BIOLOGY

Structural basis of transcription initiation by RNA polymerase II

(2015) Sarah Sainsbury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sound of silence: the properties and functions of repressive Lys methyltransferases

(2015) Chiara Mozzetta et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterizing the Covalent Targets of a Small Molecule Inhibitor of the Lysine Acetyltransferase P300

(2015) Jonathan H. Shrimp et al.   ACS Medicinal Chemistry Letters

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Looping Back to Leap Forward: Transcription Enters a New Era

(2014) Michael Levine et al.   CELL

Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

(2014) Nobuaki Shiraki et al.   Cell Metabolism

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

A High-Throughput Fluorimetric Assay for 2-Hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor

(2014) A. Elhammali et al.   Cancer Discovery

Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression

(2014) Caroline Kuiper et al.   Frontiers in Oncology

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

(2013) Gabriella Ficz et al.   Cell Stem Cell

Whole-Genome Bisulfite Sequencing of Two Distinct Interconvertible DNA Methylomes of Mouse Embryonic Stem Cells

(2013) Ehsan Habibi et al.   Cell Stem Cell

Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations

(2013) Ashkan Emadi et al.   EXPERIMENTAL HEMATOLOGY

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

(2013) C. Chen et al.   GENES & DEVELOPMENT

Induction of sarcomas by mutant IDH2

(2013) C. Lu et al.   GENES & DEVELOPMENT

Nutritional Control of Epigenetic Processes in Yeast and Human Cells

(2013) Meru J. Sadhu et al.   GENETICS

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methionine Adenosyltransferase II-dependent Histone H3K9 Methylation at theCOX-2Gene Locus

(2013) Yohei Kera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

Vitamin C modulates TET1 function during somatic cell reprogramming

(2013) Jiekai Chen et al.   NATURE GENETICS

Naive pluripotency is associated with global DNA hypomethylation

(2013) Harry G Leitch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

(2012) Wenyu Zhou et al.   EMBO JOURNAL

Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype

(2012) Natalie E. Simpson et al.   Epigenetics

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

(2012) N. Shyh-Chang et al.   SCIENCE

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine

(2012) J. A. Hackett et al.   SCIENCE

SDH mutations in cancer

(2011) Chiara Bardella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression

(2011) Natalie E. Simpson et al.   BREAST CANCER RESEARCH AND TREATMENT

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein

(2011) Yasutake Katoh et al.   MOLECULAR CELL

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Physics of protein–DNA interactions: mechanisms of facilitated target search

(2010) Anatoly B. Kolomeisky   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Global Chromatin Architecture Reflects Pluripotency and Lineage Commitment in the Early Mouse Embryo

(2010) Kashif Ahmed et al.   PLoS One

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA