A drive in SUVs: From development to disease

The methyltransferaseSetdb1is essential for meiosis and mitosis in mouse oocytes and early embryos

(2016) Angeline Eymery et al.   DEVELOPMENT

Unexpected Distinct Roles of the Related Histone H3 Lysine 9 Methyltransferases G9a and G9a-Like Protein in Myoblasts

(2016) Valentine Battisti et al.   JOURNAL OF MOLECULAR BIOLOGY

G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation

(2016) Vinay Kumar Rao et al.   NUCLEIC ACIDS RESEARCH

Human EHMT2/G9a activates p53 through methylation-independent mechanism

(2016) M Rada et al.   ONCOGENE

Involvement of G9A-like protein (GLP) in the development of mouse preimplantation embryos in vitro

(2016) Xian-Ju Huang et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription

(2016) Manzar Hossain et al.   eLife

The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration

(2016) Regan-Heng Zhang et al.   Skeletal Muscle

Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation

(2016) Sophie Beyer et al.   Cell Discovery

G9a inhibits MEF2C activity to control sarcomere assembly

(2016) Jin Rong Ow et al.   Scientific Reports

Analysis of the subcellular localization of the human histone methyltransferase SETDB1

(2015) Keisuke Tachibana et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Jmjd2C increases MyoD transcriptional activity through inhibiting G9a-dependent MyoD degradation

(2015) Eun-Shil Jung et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis

(2015) Chun-Ming Wong et al.   HEPATOLOGY

Setdb1 Is Required for Myogenic Differentiation of C2C12 Myoblast Cells via Maintenance of MyoD Expression

(2015) Young Joon Song et al.   MOLECULES AND CELLS

Sound of silence: the properties and functions of repressive Lys methyltransferases

(2015) Chiara Mozzetta et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation

(2015) Kee-Beom Kim et al.   NUCLEIC ACIDS RESEARCH

Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53

(2015) Qi Fei et al.   Nature Communications

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

(2015) Jie Zhang et al.   Oncotarget

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

(2015) Jan J Zylicz et al.   eLife

Functional Role of G9a Histone Methyltransferase in Cancer

(2015) Francesco Casciello et al.   Frontiers in Immunology

Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion

(2014) Ying-Hao Sun et al.   ASIAN JOURNAL OF ANDROLOGY

p53 Down-regulates SETDB1 gene expression during paclitaxel induced-cell death

(2014) Hee-Jung Noh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The methyltransferase G9a regulates HoxA9-dependent transcription in AML

(2014) B. Lehnertz et al.   GENES & DEVELOPMENT

Suv39h1 Mediates AP-2 -Dependent Inhibition of C/EBP  Expression during Adipogenesis

(2014) Z.-C. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis

(2014) Kuo-Tai Hua et al.   Molecular Cancer

CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression

(2014) Su Hyung Park et al.   NUCLEIC ACIDS RESEARCH

Inhibition of H3K9 Methyltransferase G9a Repressed Cell Proliferation and Induced Autophagy in Neuroblastoma Cells

(2014) Xiao-Xue Ke et al.   PLoS One

G9a is transactivated by C/EBPβ to facilitate mitotic clonal expansion during 3T3-L1 preadipocyte differentiation

(2013) Shu-Fen Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice

(2013) Monique C.M. Balemans et al.   DEVELOPMENTAL BIOLOGY

Prolyl isomerase Pin1 negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancer

(2013) Prem Khanal et al.   FASEB JOURNAL

Molecular mechanisms underlying RB protein function

(2013) Frederick A. Dick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Histone Lysine Methyltransferases SUV39H1 and SETDB1 in Gliomagenesis: Modulation of Cell Proliferation, Migration, and Colony Formation

(2013) Anastasia Spyropoulou et al.   NEUROMOLECULAR MEDICINE

Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation

(2013) Jinmi Choi et al.   NUCLEIC ACIDS RESEARCH

The Histone Methyltransferase SUV39H1 Suppresses Embryonal Rhabdomyosarcoma Formation in Zebrafish

(2013) Colleen E. Albacker et al.   PLoS One

Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

(2013) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone methylation at H3K9: Evidence for a restrictive epigenome in schizophrenia

(2013) Kayla A. Chase et al.   SCHIZOPHRENIA RESEARCH

Disruption of an EHMT1-Associated Chromatin-Modification Module Causes Intellectual Disability

(2012) Tjitske Kleefstra et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Tipping the lysine methylation balance in disease

(2012) Joshua C. Black et al.   BIOPOLYMERS

Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis

(2012) Lifeng Wang et al.   EMBO JOURNAL

G9a, a multipotent regulator of gene expression

(2012) Shilpa Rani Shankar et al.   Epigenetics

Dynamics of Setdb1 expression in early mouse development

(2012) Sunwha Cho et al.   GENE EXPRESSION PATTERNS

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

(2012) Chenfang Dong et al.   JOURNAL OF CLINICAL INVESTIGATION

G9a mediates Sharp-1–dependent inhibition of skeletal muscle differentiation

(2012) Belinda Mei Tze Ling et al.   MOLECULAR BIOLOGY OF THE CELL

Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA

(2012) Yongxin Yu et al.   MOLECULAR CELL

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

The Msx1 Homeoprotein Recruits G9a Methyltransferase to Repressed Target Genes in Myoblast Cells

(2012) Jingqiang Wang et al.   PLoS One

Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3

(2012) Tao Wang et al.   PLoS One

Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation

(2012) B. M. T. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of Glucocorticoid Receptor target genes

(2012) D. Bittencourt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine methylation: beyond histones

(2011) Xi Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation

(2011) Wei Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Chromatin landscape

(2011) Joshua C. Black et al.   Epigenetics

Dual Functions of Histone-LysineN-Methyltransferase Setdb1 Protein at Promyelocytic Leukemia-Nuclear Body (PML-NB)

(2011) Sunwha Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of Suv39H1 by SirT1 Is Part of Oxidative Stress Response and Ensures Genome Protection

(2011) Laia Bosch-Presegué et al.   MOLECULAR CELL

DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells

(2011) Akiko Takahashi et al.   MOLECULAR CELL

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

Deciphering arginine methylation: Tudor tells the tale

(2011) Chen Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence

(2010) Maurice Reimann et al.   CANCER CELL

H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

(2010) M.-W. Chen et al.   CANCER RESEARCH

Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cells

(2010) Valentina Guasconi et al.   Epigenetics

Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294

(2010) Kenichi Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Demethylase LSD1 Regulates Adipogenesis

(2010) Melina M. Musri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CLLD8/KMT1F Is a Lysine Methyltransferase That Is Important for Chromosome Segregation

(2010) Claire Falandry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

(2010) Jing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B

(2010) Y. Jiang et al.   JOURNAL OF NEUROSCIENCE

A Subset of the Histone H3 Lysine 9 Methyltransferases Suv39h1, G9a, GLP, and SETDB1 Participate in a Multimeric Complex

(2010) Lauriane Fritsch et al.   MOLECULAR CELL

The HP1α–CAF1–SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin

(2009) Alejandra Loyola et al.   EMBO REPORTS

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

(2009) Paul A Northcott et al.   NATURE GENETICS

Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex

(2009) Anne Schaefer et al.   NEURON

Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?

(2008) T. Clouaire et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

(2008) Makoto Tachibana et al.   EMBO JOURNAL

SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP

(2008) Neriman Tuba Gulbagci et al.   EMBO REPORTS

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules

(2008) Robert E Collins et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

(2008) Jong Kyong Kim et al.   NUCLEIC ACIDS RESEARCH