Effects of sequentially applied single and combined temozolomide, hydroxychloroquine and AT101 treatment in a long-term stimulation glioblastoma in vitro model

Versatile hyaluronic acid modified AQ4N-Cu(II)-gossypol infinite coordination polymer nanoparticles: Multiple tumor targeting, highly efficient synergistic chemotherapy, and real-time self-monitoring

(2018) Shihong Shen et al.   BIOMATERIALS

A novel role of the mitochondrial permeability transition pore in (−)-gossypol-induced mitochondrial dysfunction

(2018) Verena Warnsmann et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Recent advances in gossypol derivatives and analogs: a chemistry and biology view

(2017) Yuzhi Lu et al.   Future Medicinal Chemistry

Preparation and evaluation of molecularly imprinted polymer for selective recognition and adsorption of gossypol

(2017) Keke Zhi et al.   JOURNAL OF MOLECULAR RECOGNITION

Dormant glioblastoma cells acquire stem cell characteristics and are differentially affected by Temozolomide and AT101 treatment

(2017) Vivian Adamski et al.   Oncotarget

Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin

(2016) Yang Wang et al.   Autophagy

Targeting autophagy to sensitive glioma to temozolomide treatment

(2016) Yuanliang Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic–Induced Apoptosis

(2016) Patrick Antonietti et al.   MOLECULAR CANCER THERAPEUTICS

The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells

(2015) Seung Woo Lee et al.   CANCER LETTERS

Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors

(2015) Encouse B. Golden et al.   Neurosurgical Focus

Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer

(2015) Shuraila F. Zerp et al.   Radiation Oncology

Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression

(2015) Gloria Perazzoli et al.   PLoS One

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

(2014) Reshma Rangwala et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models

(2014) M A Jarzabek et al.   BRITISH JOURNAL OF CANCER

Toxicity Profile of Temozolomide in the Treatment of 300 Malignant Glioma Patients in Korea

(2014) So Hyun Bae et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

The Human Fetal Glial Cell Line SVG p12 Contains Infectious BK Polyomavirus

(2014) S. Henriksen et al.   JOURNAL OF VIROLOGY

A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer

(2013) William R. Schelman et al.   INVESTIGATIONAL NEW DRUGS

Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer

(2011) G. Sonpavde et al.   ANNALS OF ONCOLOGY

Heterogeneity Maintenance in Glioblastoma: A Social Network

(2011) R. Bonavia et al.   CANCER RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Phase I/II Study of AT-101 with Topotecan in Relapsed and Refractory Small Cell Lung Cancer

(2010) Rebecca Suk Heist et al.   Journal of Thoracic Oncology

Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

(2010) Camilla Krakstad et al.   Molecular Cancer

The Pan-Bcl-2 Inhibitor (-)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma

(2010) V. Voss et al.   MOLECULAR CANCER RESEARCH

Impact of p53 status to response of temozolomide in low MGMT expression glioblastomas: preliminary results

(2008) Shouwei Li et al.   NEUROLOGICAL RESEARCH