Recent advances in gossypol derivatives and analogs: a chemistry and biology view

Gossypol-Capped Mitoxantrone-Loaded Mesoporous SiO2 NPs for the Cooperative Controlled Release of Two Anti-Cancer Drugs

(2016) Vered Heleg-Shabtai et al.   ACS Applied Materials & Interfaces

Synthesis and antiviral, insecticidal, and fungicidal activities of gossypol derivatives containing alkylimine, oxime or hydrazine moiety

(2016) Ling Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, structure and antimicrobial evaluation of a new gossypol triazole conjugates functionalized with aliphatic chains and benzyloxy groups

(2016) Krystian Pyta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules

(2016) Jeremy L. Yap et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins

(2016) Yuzhi Lu et al.   ACS Medicinal Chemistry Letters

Antiviral mechanism study of gossypol and its Schiff base derivatives based on reactive oxygen species (ROS)

(2016) Bin Zhang et al.   RSC Advances

Efficient Synthesis of Sterically Hindered Arenes Bearing Acyclic Secondary Alkyl Groups by Suzuki-Miyaura Cross-Couplings

(2015) Chengxi Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

(2015) R. Pan et al.   BLOOD

Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1

(2015) Andrew M. Beekman et al.   ChemMedChem

A Novel Bioavailable BH3 Mimetic Efficiently Inhibits Colon Cancer via Cascade Effects of Mitochondria

(2015) X. Wang et al.   CLINICAL CANCER RESEARCH

Selenium-Containing Chrysin and Quercetin Derivatives: Attractive Scaffolds for Cancer Therapy

(2015) Inês L. Martins et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gossypol-Cross-Linked Boronic Acid-Modified Hydrogels: A Functional Matrix for the Controlled Release of an Anticancer Drug

(2015) Vered Heleg-Shabtai et al.   LANGMUIR

Natural product (−)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1

(2015) Lan Lan et al.   Molecular Oncology

Current treatment strategies for inhibiting mTOR in cancer

(2015) Francesca Chiarini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis

(2015) Shankar Varadarajan et al.   NEOPLASIA

Design, Synthesis, and Biological Activities of Aromatic Gossypol Schiff Base Derivatives

(2014) Ling Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synthesis and anti-H5N1 activity of chiral gossypol derivatives and its analogs implicated by a viral entry blocking mechanism

(2013) Jian Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluation and critical assessment of putative MCL-1 inhibitors

(2013) S Varadarajan et al.   CELL DEATH AND DIFFERENTIATION

Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in vivo model

(2013) G. Sharmila et al.   CLINICAL NUTRITION

Regioselective Oxidative Dehydrogenation under Nonenzymatic Conditions: A Synthetic Route to Gossypol

(2013) Ling Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer

(2013) William R. Schelman et al.   INVESTIGATIONAL NEW DRUGS

Alkyl esters of gallic acid as anticancer agents: A review

(2012) Claudriana Locatelli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Stability and antioxidant activity of gossypol derivative immobilized on N-polyvinylpyrrolidone

(2012) Maksim Ionov et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibitory Effects of Gossypol, Gossypolone, and Apogossypolone on a Collection of Economically Important Filamentous Fungi

(2012) Jay E. Mellon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

1H NMR study on the solvent effect on imine-enamine tautomerism of the condensation product of gossypol with 4-aminoantipyrine

(2012) K. Z. Tilyabaev et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Gossypol-induced suicidal erythrocyte death

(2012) Mohanad Zbidah et al.   TOXICOLOGY

Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer

(2011) G. Sonpavde et al.   ANNALS OF ONCOLOGY

Synthesis and antiviral activities of novel gossypol derivatives

(2011) Jian Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel O-glycosidic gossypol isomers and their bioactivities

(2011) Juanjuan Yin et al.   CARBOHYDRATE RESEARCH

A Phase II Study of AT-101 (Gossypol) in Chemotherapy-Sensitive Recurrent Extensive-Stage Small Cell Lung Cancer

(2011) Maria Q. Baggstrom et al.   Journal of Thoracic Oncology

(-)-Gossypol Suppresses the Growth of Human Prostate Cancer Xenografts via Modulating VEGF Signaling-Mediated Angiogenesis

(2011) X. Pang et al.   MOLECULAR CANCER THERAPEUTICS

An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins

(2011) Jun Wei et al.   Frontiers in Oncology

Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo

(2010) Yuan Sun et al.   CANCER BIOLOGY & THERAPY

A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum

(2010) J Lian et al.   CELL DEATH AND DIFFERENTIATION

Synthesis and Biological Evaluation of Apogossypolone Derivatives as Pan-active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins

(2010) Jun Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Water-Soluble Gossypol Derivative Increases Chemotherapeutic Sensitivity and Promotes Growth Inhibition in Colon Cancer

(2010) Fei Yan et al.   JOURNAL OF MEDICINAL CHEMISTRY

BI-97C1, an Optically Pure Apogossypol Derivative as Pan-Active Inhibitor of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins

(2010) Jun Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evidence for a Trianion Intermediate in the Metalation of 4-Hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic Acid. Methodology and Application to Racemic 5,5′-Didesisopropyl-5,5′-dialkylapogossypol Derivatives

(2010) Tin Thanh Le et al.   JOURNAL OF ORGANIC CHEMISTRY

Phase I/II Study of AT-101 with Topotecan in Relapsed and Refractory Small Cell Lung Cancer

(2010) Rebecca Suk Heist et al.   Journal of Thoracic Oncology

Gossypol Induces Apoptosis by Activating p53 in Prostate Cancer Cells and Prostate Tumor-Initiating Cells

(2010) S. R. Volate et al.   MOLECULAR CANCER THERAPEUTICS

The influence of protonation on molecular structure and physico-chemical properties of gossypol Schiff bases

(2010) Piotr Przybylski et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design and Synthesis of a Gossypol Derivative with Improved Antitumor Activities

(2009) Yonghua Zhan et al.   ARCHIV DER PHARMAZIE

Antifungal activity of alkyl and heterocyclic aza-derivatives of gossypol as well as their complexes with NaClO4 against Fusarium oxysporum f. sp. lupini

(2009) Piotr Przybylski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TW-37, a Small-Molecule Inhibitor of Bcl-2, Inhibits Cell Growth and Induces Apoptosis in Pancreatic Cancer: Involvement of Notch-1 Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

An Open-Label, Multicenter, Phase I/II Study of Single-Agent AT-101 in Men with Castrate-Resistant Prostate Cancer

(2009) G. Liu et al.   CLINICAL CANCER RESEARCH

Biological Properties of Schiff Bases and Azo Derivatives of Phenols

(2009) Piotr Przybylski et al.   CURRENT ORGANIC CHEMISTRY

Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling

(2009) Long Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, crystal structures and antibacterial activity studies of aza-derivatives of phytoalexin from cotton plant – gossypol

(2009) Piotr Przybylski et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Vascular endothelial growth inhibitor in human cancer (Review)

(2009) Jiang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Immobilization of Gossypol Derivative onN-Polyvinylpyrrolidone Increases its Water Solubility and Modifies Membrane-Active Properties

(2009) Maksim Ionov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Apogossypol Derivatives as Pan-Active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins

(2009) Jun Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway

(2009) Zhe-Yu Hu et al.   Journal of Translational Medicine

A Novel Synthesis Method of Apogossypolone and its Antitumor Activity

(2009) Yonghua Zhan et al.   Letters in Drug Design & Discovery

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins

(2009) J. Wei et al.   MOLECULAR CANCER THERAPEUTICS

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

(2009) Shuraila F Zerp et al.   Radiation Oncology

Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma

(2008) L. Paoluzzi et al.   BLOOD

Gossypol suppresses NF-κB activity and NF-κB-related gene expression in human leukemia U937 cells

(2008) Dong-Oh Moon et al.   CANCER LETTERS

Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists

(2008) Jun Wei et al.   CANCER LETTERS

ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts

(2008) Zhe-Yu Hu et al.   INTERNATIONAL JOURNAL OF CANCER

Acylpyrogallols as Inhibitors of Antiapoptotic Bcl-2 Proteins

(2008) Guozhi Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

(2008) Alan A Arnold et al.   Molecular Cancer

Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa

(2008) Y. Meng et al.   MOLECULAR CANCER THERAPEUTICS

BCL-2 family antagonists for cancer therapy

(2008) Guillaume Lessene et al.   NATURE REVIEWS DRUG DISCOVERY