Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models

BH3 Mimetics Reactivate Autophagic Cell Death in Anoxia-Resistant Malignant Glioma Cells

(2015) Holger Hetschko et al.   NEOPLASIA

Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis

(2013) Á. C. Murphy et al.   APOPTOSIS

Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells

(2013) Eduardo C Filippi-Chiela et al.   BMC CANCER

Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): an integrated multidisciplinary commentary

(2013) Monika A. Jarzabek et al.   DRUG DISCOVERY TODAY

Mechanism of temozolomide-induced antitumour effects on glioma cells

(2013) Wei Shen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Lactate-Modulated Induction of THBS-1 Activates Transforming Growth Factor (TGF)-beta2 and Migration of Glioma Cells In Vitro

(2013) Corinna Seliger et al.   PLoS One

The small GTPase RhoG mediates glioblastoma cell invasion

(2012) Aneta Kwiatkowska et al.   Molecular Cancer

O(6)-Methylguanine-DNA Methyltransferase Is a Novel Negative Effector of Invasion in Glioblastoma Multiforme

(2012) M. Chahal et al.   MOLECULAR CANCER THERAPEUTICS

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Central roles of apoptotic proteins in mitochondrial function

(2012) S M Kilbride et al.   ONCOGENE

Angiogenesis and invasion in glioma

(2011) Manabu Onishi et al.   Brain Tumor Pathology

The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma

(2011) Shwetal Mehta et al.   CANCER CELL

Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling

(2011) Jiahua Jiang et al.   CLINICAL & EXPERIMENTAL METASTASIS

(-)-Gossypol Suppresses the Growth of Human Prostate Cancer Xenografts via Modulating VEGF Signaling-Mediated Angiogenesis

(2011) X. Pang et al.   MOLECULAR CANCER THERAPEUTICS

A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo

(2011) D. S. Ziegler et al.   NEURO-ONCOLOGY

ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1

(2011) Bryan W. Day et al.   NEURO-ONCOLOGY

Use of the ODD-Luciferase Transgene for the Non-Invasive Imaging of Spontaneous Tumors in Mice

(2011) Scott J. Goldman et al.   PLoS One

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A reproducible brain tumour model established from human glioblastoma biopsies

(2010) Jian Wang et al.   BMC CANCER

MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol

(2010) Yu Ren et al.   BMC CANCER

Combination of temozolomide with immunocytokine F16–IL2 for the treatment of glioblastoma

(2010) M Pedretti et al.   BRITISH JOURNAL OF CANCER

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

(2010) Camilla Krakstad et al.   Molecular Cancer

The Pan-Bcl-2 Inhibitor (-)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma

(2010) V. Voss et al.   MOLECULAR CANCER RESEARCH

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Intravenously Administered Alphavirus Vector VA7 Eradicates Orthotopic Human Glioma Xenografts in Nude Mice

(2010) Jari E. Heikkilä et al.   PLoS One

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype

(2009) T.-C. A. Johannessen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

BH3 Peptides Induce Mitochondrial Fission and Cell Death Independent of BAX/BAK

(2009) Emelyn H. Shroff et al.   PLoS One

Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy

(2008) Asfar S. Azmi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion

(2008) Pawan Kumar et al.   LABORATORY INVESTIGATION

Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa

(2008) Y. Meng et al.   MOLECULAR CANCER THERAPEUTICS

Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells

(2008) Claire Marie-Elisabeth Sauvageot et al.   NEURO-ONCOLOGY