Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling

Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin

(2017) Thomas H. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell

(2017) Sandra L. Schmid   JOURNAL OF CELL BIOLOGY

Localization of mTORC2 activity inside cells

(2017) Michael Ebner et al.   JOURNAL OF CELL BIOLOGY

Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

(2017) Amod Godbole et al.   Nature Communications

β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ

(2016) Frédéric G Jean-Alphonse et al.   Nature Chemical Biology

Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells

(2015) Selina Jessica Keppler et al.   IMMUNITY

G Protein-coupled Receptor (GPCR) Signaling via Heterotrimeric G Proteins from Endosomes

(2015) Nikoleta G. Tsvetanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Endosomal Sorting Complex Required for Transport Pathway Mediates Chemokine Receptor CXCR4-promoted Lysosomal Degradation of the Mammalian Target of Rapamycin Antagonist DEPTOR

(2015) Rita Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin endosomal signalling suppresses anoikis

(2015) Jonna Alanko et al.   NATURE CELL BIOLOGY

Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

(2015) Roberto Villaseñor et al.   eLife

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

(2014) Nikoleta G Tsvetanova et al.   Nature Chemical Biology

Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

(2013) Xiang H.-F. Zhang et al.   CELL

Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors

(2013) R. J. Park et al.   JOURNAL OF CELL SCIENCE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Novel Roles for the E3 Ubiquitin Ligase Atrophin-interacting Protein 4 and Signal Transduction Adaptor Molecule 1 in G Protein-coupled Receptor Signaling

(2012) Rohit Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The PDZ Protein GIPC Regulates Trafficking of the LPA1 Receptor from APPL Signaling Endosomes and Attenuates the Cell’s Response to LPA

(2012) Tal Varsano et al.   PLoS One

The Adapter Protein APPL1 Links FSH Receptor to Inositol 1,4,5-Trisphosphate Production and Is Implicated in Intracellular Ca2+Mobilization

(2011) Richard M. Thomas et al.   ENDOCRINOLOGY

Deep proteome and transcriptome mapping of a human cancer cell line

(2011) N. Nagaraj et al.   Molecular Systems Biology

Endocytosis Promotes Rapid Dopaminergic Signaling

(2011) Sarah J. Kotowski et al.   NEURON

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Early Endosomal Antigen 1 (EEA1) Is an Obligate Scaffold for Angiotensin II-induced, PKC-α-dependent Akt Activation in Endosomes

(2010) Rafal Robert Nazarewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrestin-2 Interacts with the Endosomal Sorting Complex Required for Transport Machinery to Modulate Endosomal Sorting of CXCR4

(2010) Rohit Malik et al.   MOLECULAR BIOLOGY OF THE CELL

CXCL12 Chemokine Expression and Secretion Regulates Colorectal Carcinoma Cell Anoikis through Bim-Mediated Intrinsic Apoptosis

(2010) Luke J. Drury et al.   PLoS One

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells

(2009) M Kochetkova et al.   CELL DEATH AND DIFFERENTIATION

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

G Protein-coupled Receptor-promoted Trafficking of Gβ1γ2 Leads to AKT Activation at Endosomes via a Mechanism Mediated by Gβ1γ2-Rab11a Interaction

(2008) Alejandro García-Regalado et al.   MOLECULAR BIOLOGY OF THE CELL