Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

GPCR Signaling and Trafficking: The Long and Short of It

(2017) Nathan J. Pavlos et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs

(2016) Katherine C. Varandas et al.   CURRENT BIOLOGY

Persistent cAMP Signaling by Internalized LH Receptors in Ovarian Follicles

(2016) Sandra Lyga et al.   ENDOCRINOLOGY

cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons

(2016) Isabella Maiellaro et al.   Cell Reports

Effects of endocytosis on receptor-mediated signaling

(2015) Roshanak Irannejad et al.   CURRENT OPINION IN CELL BIOLOGY

Rab4 Orchestrates a Small GTPase Cascade for Recruitment of Adaptor Proteins to Early Endosomes

(2014) Ryan S. D’Souza et al.   CURRENT BIOLOGY

Endosomal generation of cAMP in GPCR signaling

(2014) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

(2014) Nikoleta G Tsvetanova et al.   Nature Chemical Biology

cAMP signaling in subcellular compartments

(2014) Konstantinos Lefkimmiatis et al.   PHARMACOLOGY & THERAPEUTICS

cAMP signaling microdomains and their observation by optical methods

(2014) Davide Calebiro et al.   Frontiers in Cellular Neuroscience

Gαs regulates the post-endocytic sorting of G protein-coupled receptors

(2014) Stéphanie Rosciglione et al.   Nature Communications

Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells

(2013) Ramya S. Kuna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Brief History of G-Protein Coupled Receptors (Nobel Lecture)

(2013) Robert J. Lefkowitz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetics and mechanism of G protein-coupled receptor activation

(2013) Martin J Lohse et al.   CURRENT OPINION IN CELL BIOLOGY

Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters

(2013) Laure Cazabat et al.   HUMAN MOLECULAR GENETICS

Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin

(2013) Timothy N. Feinstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases

(2013) Marco Conti et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pituitary Adenylate Cyclase 1 Receptor Internalization and Endosomal Signaling Mediate the Pituitary Adenylate Cyclase Activating Polypeptide-Induced Increase in Guinea Pig Cardiac Neuron Excitability

(2013) L. A. Merriam et al.   JOURNAL OF NEUROSCIENCE

Receptor signals come in waves

(2013) Martin J. Lohse et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells

(2012) Ruth C. Werthmann et al.   FASEB JOURNAL

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signaling Circuits on the Golgi Complex

(2012) Jorge Cancino et al.   TRAFFIC

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Retromer terminates the generation of cAMP by internalized PTH receptors

(2011) Timothy N Feinstein et al.   Nature Chemical Biology

FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells

(2011) Sebastian Börner et al.   Nature Protocols

Endocytosis Promotes Rapid Dopaminergic Signaling

(2011) Sarah J. Kotowski et al.   NEURON

Structural flexibility of the G s  -helical domain in the  2-adrenoceptor Gs complex

(2011) G. H. Westfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

Signaling by internalized G-protein-coupled receptors

(2010) Davide Calebiro et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

Clathrin is a key regulator of basolateral polarity

(2008) Sylvie Deborde et al.   NATURE

Highly inclined thin illumination enables clear single-molecule imaging in cells

(2008) Makio Tokunaga et al.   NATURE METHODS

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Structure of Vps26B and Mapping of its Interaction with the Retromer Protein Complex

(2008) Brett M. Collins et al.   TRAFFIC