Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria

The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species

(2018) Natalia S. Nemeria et al.   FREE RADICAL BIOLOGY AND MEDICINE

The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate

(2017) Natalia S. Nemeria et al.   FREE RADICAL BIOLOGY AND MEDICINE

Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS

(2017) Jieyu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase

(2017) Sara Sanders et al.   ACS Infectious Diseases

Competence of Thiamin Diphosphate-Dependent Enzymes with 2′-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin

(2016) Natalia S. Nemeria et al.   BIOCHEMISTRY

Mechanistic binding insights for 1-deoxy-d-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax

(2016) Matthew R. Battistini et al.   PROTEIN EXPRESSION AND PURIFICATION

Decarboxylation, CO2 and the Reversion Problem

(2015) Ronald Kluger   ACCOUNTS OF CHEMICAL RESEARCH

Hydroxybenzaldoximes AreD-GAP-Competitive Inhibitors ofE. coli1-Deoxy-D-Xylulose-5-Phosphate Synthase

(2015) David Bartee et al.   CHEMBIOCHEM

A simple method for decomposition of peracetic acid in a microalgal cultivation system

(2014) Min-Gyu Sung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Defining critical residues for substrate binding to 1-deoxy-d-xylulose 5-phosphate synthase - active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate

(2014) Leighanne A. Brammer Basta et al.   FEBS Journal

Human 2-Oxoglutarate Dehydrogenase Complex E1 Component Forms a Thiamin-derived Radical by Aerobic Oxidation of the Enamine Intermediate

(2014) Natalia S. Nemeria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DXP Synthase-Catalyzed CN Bond Formation: Nitroso Substrate Specificity Studies Guide Selective Inhibitor Design

(2013) Francine Morris et al.   CHEMBIOCHEM

Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate

(2013) Jessica M Smith et al.   JOURNAL OF ANTIBIOTICS

A High-Throughput Microtiter Plate Based Method for the Determination of Peracetic Acid and Hydrogen Peroxide

(2013) Karson S. Putt et al.   PLoS One

Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?

(2012) Qinglin Du et al.   International Journal of Biological Sciences

Observation of Thiamin-Bound Intermediates and Microscopic Rate Constants for Their Interconversion on 1-Deoxy-d-xylulose 5-Phosphate Synthase: 600-Fold Rate Acceleration of Pyruvate Decarboxylation by d-Glyceraldehyde-3-phosphate.

(2012) Hetalben Patel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

1-Deoxy-d-xylulose 5-Phosphate Synthase Catalyzes a Novel Random Sequential Mechanism

(2011) Leighanne A. Brammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective inhibition of E. coli1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates

(2011) Jessica M. Smith et al.   MedChemComm

Isotope Effect, Mechanism, and Origin of Catalysis in the Decarboxylation of Mandelylthiamin

(2010) Ollie M. Gonzalez-James et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Internal Return of Carbon Dioxide in Decarboxylation: Catalysis of Separation and12C/13C Kinetic Isotope Effects

(2009) Scott O. C. Mundle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Revealing Substrate Promiscuity of 1-Deoxy-d-xylulose 5-Phosphate Synthase

(2009) Leighanne A. Brammer et al.   ORGANIC LETTERS