Hydroxybenzaldoximes AreD-GAP-Competitive Inhibitors ofE. coli1-Deoxy-D-Xylulose-5-Phosphate Synthase

Defining critical residues for substrate binding to 1-deoxy-d-xylulose 5-phosphate synthase - active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate

(2014) Leighanne A. Brammer Basta et al.   FEBS Journal

Development of Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

(2014) Tiziana Masini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Deoxyxylulose 5-Phosphate Synthase Controls Flux through the Methylerythritol 4-Phosphate Pathway in Arabidopsis

(2014) L. P. Wright et al.   PLANT PHYSIOLOGY

De novo fragment-based design of inhibitors of DXS guided by spin-diffusion-based NMR spectroscopy

(2014) T. Masini et al.   Chemical Science

DXP Synthase-Catalyzed CN Bond Formation: Nitroso Substrate Specificity Studies Guide Selective Inhibitor Design

(2013) Francine Morris et al.   CHEMBIOCHEM

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase

(2013) Daisuke Hayashi et al.   CHEMICAL COMMUNICATIONS

Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate

(2013) Jessica M Smith et al.   JOURNAL OF ANTIBIOTICS

Feedback Inhibition of Deoxy-d-xylulose-5-phosphate Synthase Regulates the Methylerythritol 4-Phosphate Pathway

(2013) Aparajita Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In search of new herbicidal inhibitors of the non-mevalonate pathway

(2013) Matthias Witschel et al.   PEST MANAGEMENT SCIENCE

2C-Methyl-d-erythritol 4-Phosphate Enhances and Sustains Cyclodiphosphate Synthase IspF Activity

(2012) J. Kipchirchir Bitok et al.   ACS Chemical Biology

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

(2012) P. D. Tamma et al.   CLINICAL MICROBIOLOGY REVIEWS

Observation of Thiamin-Bound Intermediates and Microscopic Rate Constants for Their Interconversion on 1-Deoxy-d-xylulose 5-Phosphate Synthase: 600-Fold Rate Acceleration of Pyruvate Decarboxylation by d-Glyceraldehyde-3-phosphate.

(2012) Hetalben Patel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isoprenoid biosynthesis in bacterial pathogens

(2012) S. Heuston et al.   MICROBIOLOGY-SGM

1-Deoxy-d-xylulose 5-Phosphate Synthase Catalyzes a Novel Random Sequential Mechanism

(2011) Leighanne A. Brammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective inhibition of E. coli1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates

(2011) Jessica M. Smith et al.   MedChemComm

A Direct Entry to Substituted N-Methoxyamines from N-Methoxyamides via N-Oxyiminium Ions

(2010) Kenji Shirokane et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae

(2010) Yukiko Matsue et al.   JOURNAL OF ANTIBIOTICS

Revealing Substrate Promiscuity of 1-Deoxy-d-xylulose 5-Phosphate Synthase

(2009) Leighanne A. Brammer et al.   ORGANIC LETTERS

Structure–activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase

(2008) Jialin Mao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS