Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS

Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry

(2017) Palaniappan S. Chetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competence of Thiamin Diphosphate-Dependent Enzymes with 2′-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin

(2016) Natalia S. Nemeria et al.   BIOCHEMISTRY

Mechanistic binding insights for 1-deoxy-d-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax

(2016) Matthew R. Battistini et al.   PROTEIN EXPRESSION AND PURIFICATION

Hydroxybenzaldoximes AreD-GAP-Competitive Inhibitors ofE. coli1-Deoxy-D-Xylulose-5-Phosphate Synthase

(2015) David Bartee et al.   CHEMBIOCHEM

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Elucidation of the Interaction Loci of the Human Pyruvate Dehydrogenase Complex E2·E3BP Core with Pyruvate Dehydrogenase Kinase 1 and Kinase 2 by H/D Exchange Mass Spectrometry and Nuclear Magnetic Resonance

(2014) Junjie Wang et al.   BIOCHEMISTRY

Mechanism and inhibition of 1-deoxy-d-xylulose-5-phosphate reductoisomerase

(2014) Andrew S. Murkin et al.   BIOORGANIC CHEMISTRY

Defining critical residues for substrate binding to 1-deoxy-d-xylulose 5-phosphate synthase - active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate

(2014) Leighanne A. Brammer Basta et al.   FEBS Journal

High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5

(2014) Jie Zheng et al.   NUCLEIC ACIDS RESEARCH

De novo fragment-based design of inhibitors of DXS guided by spin-diffusion-based NMR spectroscopy

(2014) T. Masini et al.   Chemical Science

DXP Synthase-Catalyzed CN Bond Formation: Nitroso Substrate Specificity Studies Guide Selective Inhibitor Design

(2013) Francine Morris et al.   CHEMBIOCHEM

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase

(2013) Daisuke Hayashi et al.   CHEMICAL COMMUNICATIONS

Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate

(2013) Jessica M Smith et al.   JOURNAL OF ANTIBIOTICS

Insight to the Interaction of the Dihydrolipoamide Acetyltransferase (E2) Core with the Peripheral Components in theEscherichia coliPyruvate Dehydrogenase Complex via Multifaceted Structural Approaches

(2013) Krishnamoorthy Chandrasekhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Overlapped and Noisy Hydrogen/Deuterium Exchange Mass Spectra

(2013) Miklos Guttman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

In search of new herbicidal inhibitors of the non-mevalonate pathway

(2013) Matthias Witschel et al.   PEST MANAGEMENT SCIENCE

Nucleotide-induced conformational changes of tetradecameric GroEL mapped by H/D exchange monitored by FT-ICR mass spectrometry

(2013) Qian Zhang et al.   Scientific Reports

Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?

(2012) Qinglin Du et al.   International Journal of Biological Sciences

Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry

(2012) John R. Engen et al.   INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRY

Observation of Thiamin-Bound Intermediates and Microscopic Rate Constants for Their Interconversion on 1-Deoxy-d-xylulose 5-Phosphate Synthase: 600-Fold Rate Acceleration of Pyruvate Decarboxylation by d-Glyceraldehyde-3-phosphate.

(2012) Hetalben Patel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pyridoxal phosphate: Biosynthesis and catabolism

(2011) Tathagata Mukherjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

1-Deoxy-d-xylulose 5-Phosphate Synthase Catalyzes a Novel Random Sequential Mechanism

(2011) Leighanne A. Brammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective inhibition of E. coli1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates

(2011) Jessica M. Smith et al.   MedChemComm

False EX1 signatures caused by sample carryover during HX MS analyses

(2010) Jing Fang et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae

(2010) Yukiko Matsue et al.   JOURNAL OF ANTIBIOTICS

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Efficient coupling of catalysis and dynamics in the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex

(2008) S. Kale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity of immobilized porcine pepsin in H/D exchange compatible conditions

(2008) Yoshitomo Hamuro et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY