Defining critical residues for substrate binding to 1-deoxy-d-xylulose 5-phosphate synthase - active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate

Observation of Thiamin-Bound Intermediates and Microscopic Rate Constants for Their Interconversion on 1-Deoxy-d-xylulose 5-Phosphate Synthase: 600-Fold Rate Acceleration of Pyruvate Decarboxylation by d-Glyceraldehyde-3-phosphate.

(2012) Hetalben Patel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

1-Deoxy-d-xylulose 5-Phosphate Synthase Catalyzes a Novel Random Sequential Mechanism

(2011) Leighanne A. Brammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective inhibition of E. coli1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates

(2011) Jessica M. Smith et al.   MedChemComm

Double Duty for a Conserved Glutamate in Pyruvate Decarboxylase: Evidence of the Participation in Stereoelectronically Controlled Decarboxylation and in Protonation of the Nascent Carbanion/Enamine Intermediate,

(2010) Danilo Meyer et al.   BIOCHEMISTRY

A single-molecule force spectroscopy nanosensor for the identification of new antibiotics and antimalarials

(2010) Xavier Sisquella et al.   FASEB JOURNAL

The Nonmevalonate Pathway of Isoprenoid Biosynthesis in Mycobacterium tuberculosis Is Essential and Transcriptionally Regulated by Dxs

(2010) A. C. Brown et al.   JOURNAL OF BACTERIOLOGY

Communication between Thiamin Cofactors in theEscherichia coliPyruvate Dehydrogenase Complex E1 Component Active Centers

(2010) Natalia S. Nemeria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Revealing Substrate Promiscuity of 1-Deoxy-d-xylulose 5-Phosphate Synthase

(2009) Leighanne A. Brammer et al.   ORGANIC LETTERS