Activation of airway epithelial bitter taste receptors byPseudomonas aeruginosaquinolones modulates calcium, cyclic-AMP, and nitric oxide signaling

Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system

(2018) Steven S. An et al.   CELLULAR SIGNALLING

Protease-activated receptor 2 activates airway apical membrane chloride permeability and increases ciliary beating

(2018) Derek B. McMahon et al.   FASEB JOURNAL

Spatially dependent alkyl quinolone signaling responses to antibiotics inPseudomonas aeruginosaswarms

(2018) Nydia Morales-Soto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Quinine-Responsive Taste Receptor Family 2 in Airway Immune Defense and Chronic Rhinosinusitis

(2018) Alan D. Workman et al.   Frontiers in Immunology

Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis

(2018) Alan D. Workman et al.   Journal of Allergy and Clinical Immunology-In Practice

Flavonoids SuppressPseudomonas aeruginosaVirulence through Allosteric Inhibition of Quorum-sensing Receptors

(2017) Jon E. Paczkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor

(2017) Benjamin M. Hariri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic monitoring of Gi/o-protein-mediated decreases of intracellular cAMP by FRET-based Epac sensors

(2017) Ursula Storch et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The human bitter taste receptor T2R38 is broadly tuned for bacterial compounds

(2017) Christophe Verbeurgt et al.   PLoS One

The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis

(2017) D.I. Rom et al.   RHINOLOGY

A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition

(2017) Jinshui Lin et al.   Nature Communications

Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide

(2017) Alan D. Workman et al.   International Forum of Allergy & Rhinology

In vivo and In vitro Interactions between Pseudomonas aeruginosa and Staphylococcus spp.

(2017) An Hotterbeekx et al.   Frontiers in Cellular and Infection Microbiology

The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket

(2017) Anu Thomas et al.   Scientific Reports

In vitro effects of anthocyanidins on sinonasal epithelial nitric oxide production and bacterial physiology

(2016) Benjamin M. Hariri et al.   American Journal of Rhinology & Allergy

Probing the Binding Pocket of the Broadly Tuned Human Bitter Taste Receptor TAS2R14 by Chemical Modification of Cognate Agonists

(2016) Rafik Karaman et al.   Chemical Biology & Drug Design

β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function

(2016) Donghwa Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans

(2016) Kristina Lossow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and Functional Activity of the Human Bitter Taste Receptor TAS2R38 in Human Placental Tissues and JEG-3 Cells

(2016) Ute Wölfle et al.   MOLECULES

Expression of the bitter receptor T2R38 in pancreatic cancer: localization in lipid droplets and activation by a bacteria-derived quorum-sensing molecule

(2016) Matthias M. Gaida et al.   Oncotarget

BitterX: a tool for understanding bitter taste in humans

(2016) Wenkang Huang et al.   Scientific Reports

Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function

(2016) Robert J. Lee et al.   Scientific Reports

Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients

(2016) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells

(2016) Matthias Martin Gaida et al.   Pathogens and Disease

Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function

(2016) Stefan Gahbauer et al.   Frontiers in Physiology

The role of 2,4-dihydroxyquinoline (DHQ) inPseudomonas aeruginosapathogenicity

(2016) Jordon D. Gruber et al.   PeerJ

A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs

(2015) Michelle M Sandau et al.   BMC NEUROSCIENCE

Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis

(2015) Robert J. Lee et al.   Current Opinion in Allergy and Clinical Immunology

Managing Pseudomonas aeruginosa respiratory infections in cystic fibrosis

(2015) Katherine M. Langan et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Chronic rhinosinusitis pathogenesis

(2015) Whitney W. Stevens et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Post-transcriptional regulation of gene PA5507 controlsPseudomonasquinolone signal concentration inP. aeruginosa

(2015) Kyle A. Tipton et al.   MOLECULAR MICROBIOLOGY

The GPCR heterotetramer: challenging classical pharmacology

(2015) Sergi Ferré   TRENDS IN PHARMACOLOGICAL SCIENCES

T2R38 genotype is correlated with sinonasal quality of life in homozygous ΔF508 cystic fibrosis patients

(2015) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

TAS2R38genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis

(2015) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

Ion channels and calcium signaling in motile cilia

(2015) Julia F Doerner et al.   eLife

Modulation of Host Biology by Pseudomonas aeruginosa Quorum Sensing Signal Molecules: Messengers or Traitors

(2015) Yi-Chia Liu et al.   Frontiers in Microbiology

Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone

(2015) Susanne Maurer et al.   Frontiers in Immunology

Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity

(2015) Jeffrey Klarenbeek et al.   PLoS One

Taste receptors in innate immunity

(2014) Robert J. Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Amino Acid Derivatives as Bitter Taste Receptor (T2R) Blockers

(2014) Sai P. Pydi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bitter and sweet taste receptors regulate human upper respiratory innate immunity

(2014) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Bitter and sweet taste receptors in the respiratory epithelium in health and disease

(2014) Robert J. Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genetically-Encoded Yellow Fluorescent cAMP Indicator with an Expanded Dynamic Range for Dual-Color Imaging

(2014) Haruki Odaka et al.   PLoS One

Role ofPseudomonas aeruginosaquorum sensing (QS) molecules on the viability and cytokine profile of human mesenchymal stem cells

(2014) Alina-Maria Holban et al.   Virulence

Genetic variations in taste receptors are associated with chronic rhinosinusitis: a replication study

(2014) Leandra Mfuna Endam et al.   International Forum of Allergy & Rhinology

The Pseudomonas quinolone signal (PQS) stimulates chemotaxis of polymorphonuclear neutrophils

(2014) Gertrud M. Hänsch et al.   Journal of Applied Biomaterials & Functional Materials

The Emerging Role of the Bitter Taste Receptor T2R38 in Upper Respiratory Infection and Chronic Rhinosinusitis

(2013) Robert J. Lee et al.   American Journal of Rhinology & Allergy

Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity

(2013) Xiahui Tan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion

(2013) Robert J. Lee et al.   FASEB JOURNAL

The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14

(2013) Anat Levit et al.   FASEB JOURNAL

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components

(2013) Robert J Lee et al.   Innate Immunity

Interspecies Interaction between Pseudomonas aeruginosa and Other Microorganisms

(2013) Yosuke Tashiro et al.   MICROBES AND ENVIRONMENTS

Taste perception: from the tongue to the testis

(2013) F. Li   MOLECULAR HUMAN REPRODUCTION

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention

(2013) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery

(2013) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

The Cellular and Molecular Basis of Bitter Tastant-Induced Bronchodilation

(2013) Cheng-Hai Zhang et al.   PLOS BIOLOGY

Extraoral bitter taste receptors as mediators of off-target drug effects

(2012) Adam A. Clark et al.   FASEB JOURNAL

Molecular modulation of airway epithelial ciliary response to sneezing

(2012) Ke-Qing Zhao et al.   FASEB JOURNAL

Regulator of G-protein Signaling-21 (RGS21) Is an Inhibitor of Bitter Gustatory Signaling Found in Lingual and Airway Epithelia

(2012) Staci P. Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3D Structure Prediction of TAS2R38 Bitter Receptors Bound to Agonists Phenylthiocarbamide (PTC) and 6-n-Propylthiouracil (PROP)

(2012) Jun Tan et al.   Journal of Chemical Information and Modeling

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

(2012) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa

(2012) P. Nadal Jimenez et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Oral and extra-oral taste perception

(2012) Kurumi Yamamoto et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour

(2011) F. Jerry Reen et al.   FEMS MICROBIOLOGY ECOLOGY

Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis

(2011) Yinyan Lai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2-Heptyl-4-Quinolone, a Precursor of the Pseudomonas Quinolone Signal Molecule, Modulates Swarming Motility in Pseudomonas aeruginosa

(2011) D.-G. Ha et al.   JOURNAL OF BACTERIOLOGY

The Missing Sense Modality: The Immune System

(2011) Felice L Bedford   PERCEPTION

Probenecid Inhibits the Human Bitter Taste Receptor TAS2R16 and Suppresses Bitter Perception of Salicin

(2011) Tiffani A. Greene et al.   PLoS One

Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)

(2011) Supachoke Mangmool et al.   Toxins

Oligomerization of TAS2R Bitter Taste Receptors

(2010) Christina Kuhn et al.   CHEMICAL SENSES

The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12

(2010) Danielle R. Reed et al.   HUMAN MOLECULAR GENETICS

cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways

(2010) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

(2010) Deepak A Deshpande et al.   NATURE MEDICINE

Alcohol Stimulates Ciliary Motility of Isolated Airway Axonemes Through a Nitric Oxide, Cyclase, and Cyclic Nucleotide-Dependent Kinase Mechanism

(2009) Joseph H. Sisson et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Mechanisms of Ca2+-stimulated fluid secretion by porcine bronchial submucosal gland serous acinar cells

(2009) Robert J. Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

(2009) Wolfgang Meyerhof et al.   CHEMICAL SENSES

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species

(2008) Jean-Frédéric Dubern et al.   Molecular BioSystems

The Pseudomonas Quinolone Signal (PQS) Balances Life and Death in Pseudomonas aeruginosa Populations

(2008) Susanne Häussler et al.   PLoS Pathogens