Amino Acid Derivatives as Bitter Taste Receptor (T2R) Blockers

Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development

(2014) Andrew C Kruse et al.   CURRENT OPINION IN PHARMACOLOGY

Inverse Agonism of SQ 29,548 and Ramatroban on Thromboxane A2 Receptor

(2014) Raja Chakraborty et al.   PLoS One

6-Methoxyflavanones as Bitter Taste Receptor Blockers for hTAS2R39

(2014) Wibke S. U. Roland et al.   PLoS One

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

Quantitative versus qualitative data: The numerical dimensions of drug action

(2013) David B. Bylund et al.   BIOCHEMICAL PHARMACOLOGY

The third intracellular loop plays a critical role in bitter taste receptor activation

(2013) Sai Prasad Pydi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14

(2013) Anat Levit et al.   FASEB JOURNAL

The Human Bitter Taste Receptor TAS2R10 Is Tailored to Accommodate Numerous Diverse Ligands

(2013) S. Born et al.   JOURNAL OF NEUROSCIENCE

Role of rhodopsin N-terminus in structure and function of rhodopsin-bitter taste receptor chimeras

(2012) Sai Prasad Pydi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extraoral bitter taste receptors as mediators of off-target drug effects

(2012) Adam A. Clark et al.   FASEB JOURNAL

Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation

(2012) Sai Prasad Pydi et al.   JOURNAL OF NEUROCHEMISTRY

Site-Directed Mutations and the Polymorphic Variant Ala160Thr in the Human Thromboxane Receptor Uncover a Structural Role for Transmembrane Helix 4

(2012) Raja Chakraborty et al.   PLoS One

Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs

(2012) Maik Behrens et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Functional bitter taste receptors are expressed in brain cells

(2011) Nisha Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Basis of Activation of Bitter Taste Receptor T2R1 and Comparison with Class A G-protein-coupled Receptors (GPCRs)

(2011) Nisha Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GABA, Its Receptors, and GABAergic Inhibition in Mouse Taste Buds

(2011) G. Dvoryanchikov et al.   JOURNAL OF NEUROSCIENCE

Receptor Agonism and Antagonism of Dietary Bitter Compounds

(2011) A. Brockhoff et al.   JOURNAL OF NEUROSCIENCE

Probenecid Inhibits the Human Bitter Taste Receptor TAS2R16 and Suppresses Bitter Perception of Salicin

(2011) Tiffani A. Greene et al.   PLoS One

A Gustotopic Map of Taste Qualities in the Mammalian Brain

(2011) X. Chen et al.   SCIENCE

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides

(2010) Takanobu Sakurai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bitter taste receptor T2R1 is activated by dipeptides and tripeptides

(2010) Jasbir Upadhyaya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist

(2010) Jay P. Slack et al.   CURRENT BIOLOGY

Characterization of the β-d-Glucopyranoside Binding Site of the Human Bitter Taste Receptor hTAS2R16

(2010) Takanobu Sakurai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

(2010) Deepak A Deshpande et al.   NATURE MEDICINE

Insights into the Binding of Phenyltiocarbamide (PTC) Agonist to Its Target Human TAS2R38 Bitter Receptor

(2010) Xevi Biarnés et al.   PLoS One

Structural requirements of bitter taste receptor activation

(2010) A. Brockhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

(2009) Wolfgang Meyerhof et al.   CHEMICAL SENSES

GABA expression in the mammalian taste bud functions as a route of inhibitory cell-to-cell communication

(2009) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

Masking Bitter Taste by Molecules

(2008) Jakob P. Ley   Chemosensory Perception