Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity

The Concise Guide to PHARMACOLOGY 2013/14: Overview

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ca2+oscillations, Ca2+sensitization, and contraction activated by protein kinase C in small airway smooth muscle

(2013) Seema Mukherjee et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Cellular and Molecular Basis of Bitter Tastant-Induced Bronchodilation

(2013) Cheng-Hai Zhang et al.   PLOS BIOLOGY

Inositol trisphosphate receptors in smooth muscle cells

(2012) Damodaran Narayanan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea

(2012) Ville Pulkkinen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulator of G-protein Signaling-21 (RGS21) Is an Inhibitor of Bitter Gustatory Signaling Found in Lingual and Airway Epithelia

(2012) Staci P. Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of BK channels may not be required for bitter tastant–induced bronchodilation

(2012) Cheng-Hai Zhang et al.   NATURE MEDICINE

Regulation of GPCR-mediated smooth muscle contraction: Implications for asthma and pulmonary hypertension

(2012) D.B. Wright et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Taste receptor signalling - from tongues to lungs

(2011) S. C. Kinnamon   Acta Physiologica

Agonist-Promoted Homologous Desensitization of Human Airway Smooth Muscle Bitter Taste Receptors

(2011) Kathryn S. Robinett et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

BitterDB: a database of bitter compounds

(2011) Ayana Wiener et al.   NUCLEIC ACIDS RESEARCH

Nitric oxide induces airway smooth muscle cell relaxation by decreasing the frequency of agonist-induced Ca2+oscillations

(2010) Jose F. Perez-Zoghbi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

(2010) Deepak A Deshpande et al.   NATURE MEDICINE

The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice

(2009) Yan Bai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca2+ signaling of airway smooth muscle cells

(2009) Yan Bai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effects of Formoterol on Contraction and Ca2+Signaling of Mouse Airway Smooth Muscle Cells

(2009) Philippe Delmotte et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Human Airway Contraction and Formoterol-Induced Relaxation Is Determined by Ca2+Oscillations and Ca2+Sensitivity

(2009) Anna-Rebekka Ressmeyer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

(2009) Wolfgang Meyerhof et al.   CHEMICAL SENSES

Ca2+Sparks Act as Potent Regulators of Excitation-Contraction Coupling in Airway Smooth Muscle

(2009) Ronghua ZhuGe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

Ryanodine receptors decant internal Ca2+ store in human and bovine airway smooth muscle

(2008) T. Tazzeo et al.   EUROPEAN RESPIRATORY JOURNAL

Effects of Albuterol Isomers on the Contraction and Ca2+Signaling of Small Airways in Mouse Lung Slices

(2007) Philippe Delmotte et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY