Journal
CLINICAL ENDOCRINOLOGY
Volume 85, Issue 5, Pages 772-780Publisher
WILEY-BLACKWELL
DOI: 10.1111/cen.13130
Keywords
-
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01DK075877]
- National Institutes of Health
- GlaxoSmithKline
- Center for Disease Control
- Bristol Meyers Squibb
- Novartis Pharmaceuticals
- Abbott Labs
- Takeda Pharmaceuticals
- Sankyo Pharmaceuticals North America
- Oishei Foundation
- Citrus Industry of Florida
- Solvay Pharmaceuticals
- William G. McGowan Charitable Fund
- Millard Fillmore Foundation
Ask authors/readers for more resources
ContextAs the syndrome of hypogonadotropic hypogonadism (HH) is associated with anaemia and the administration of testosterone restores haematocrit to normal, we investigated the potential underlying mechanisms. DesignRandomized, double-blind, placebo-controlled trial. MethodsWe measured basal serum concentrations of erythropoietin, iron, iron binding capacity, transferrin (saturated and unsaturated), ferritin and hepcidin and the expression of ferroportin and transferrin receptor (TR) in peripheral blood mononuclear cells (MNC) of 94 men with type 2 diabetes. Forty-four men had HH (defined as subnormal free testosterone along with low or normal LH concentrations) while 50 were eugonadal. Men with HH were randomized to testosterone or placebo treatment every 2 weeks for 15 weeks. Blood samples were collected at baseline, 3 and 15 weeks after starting treatment. Twenty men in testosterone group and 14 men in placebo group completed the study. ResultsHaematocrit levels were lower in men with HH (411 39% vs 438 +/- 34%, P = 0001). There were no differences in plasma concentrations of hepcidin, ferritin, erythropoietin, transferrin or iron, or in the expression of ferroportin or TR in MNC among HH and eugonadal men. Haematocrit increased to 453 +/- 45%, hepcidin decreased by 28 +/- 7% and erythropoietin increased by 21 +/- 7% after testosterone therapy (P < 005). There was no significant change in ferritin concentrations, but transferrin concentration increased while transferrin saturation and iron concentrations decreased (P < 005). Ferroportin and TR mRNA expression in MNC increased by 70 +/- 13% and 43 +/- 10%, respectively (P < 001), after testosterone therapy. ConclusionsThe increase in haematocrit following testosterone therapy is associated with an increase in erythropoietin, the suppression of hepcidin, and an increase in the expression of ferroportin and TR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available