Crystal Structure of LGR4-Rspo1 Complex

Investigation of Interactions at the Extracellular Loops of the Relaxin Family Peptide Receptor 1 (RXFP1)

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Lgr proteins in epithelial stem cell biology

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The structural basis of R-spondin recognition by LGR5 and RNF43

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

(2013) D. Wang et al.   GENES & DEVELOPMENT

Crystal Structures of Lgr4 and Its Complex with R-Spondin1

(2013) Kai Xu et al.   STRUCTURE

Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

(2013) Weng Chuan Peng et al.   Cell Reports

Wnt/β-Catenin Signaling and Disease

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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The R-spondin family of proteins: Emerging regulators of WNT signaling

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

(2012) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of TLR5-Flagellin Recognition and Signaling

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Structural basis for high-affinity HER2 receptor binding by an engineered protein

(2010) C. Eigenbrot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimerization and Negative Cooperativity in the Relaxin Family Peptide Receptors

(2009) Angela Manegold Svendsen et al.   Annals of the New York Academy of Sciences

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

(2008) S. M. Bell et al.   DEVELOPMENT

R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

(2008) Kyung-Ah Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Comparative genomics of leucine-rich repeats containing G protein-coupled receptors and their ligands

(2007) Tom Van Loy et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY