Miniature Swine for Preclinical Modeling of Complexities of Human Disease for Translational Scientific Discovery and Accelerated Development of Therapies and Medical Devices

The economic impact of obesity in the United States

(2016) Ross Hammond et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

A study of lymphoid organs and serum proinflammatory cytokines in pigs infected with African swine fever virus genotype II

(2015) Hovakim Zakaryan et al.   ARCHIVES OF VIROLOGY

Distribution of miRNA genes in the pig genome

(2015) Paulina Paczynska et al.   BMC GENETICS

Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes

(2015) Michael L. Multhaup et al.   Cell Metabolism

The gut microbiome in health and in disease

(2015) Andrew B. Shreiner et al.   CURRENT OPINION IN GASTROENTEROLOGY

Swine as a Model for Influenza A Virus Infection and Immunity

(2015) D. S. Rajao et al.   ILAR JOURNAL

MicroRNAs mediated targeting on the Yin-yang dynamics of DNA methylation in disease and development

(2015) Jiajie Tu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Microminipigs as a new experimental animal model for toxicological studies: comparative pharmacokinetics of perfluoroalkyl acids

(2015) Keerthi S. Guruge et al.   JOURNAL OF APPLIED TOXICOLOGY

Mild Hypothermia Inhibits Systemic and Cerebral Complement Activation in a Swine Model of Cardiac Arrest

(2015) Ping Gong et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The $2.6 Billion Pill — Methodologic and Policy Considerations

(2015) Jerry Avorn   NEW ENGLAND JOURNAL OF MEDICINE

The Cost of Drug Development

(2015) Joseph A. DiMasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transgenerational inheritance of metabolic disease

(2015) Rachel Stegemann et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Intergenerational epigenetic inheritance in models of developmental programming of adult disease

(2015) Denise S. Fernandez-Twinn et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Two swine models of iliac vein occlusion: Which form most contributes to venous thrombosis?

(2015) Wan-Yin Shi et al.   THROMBOSIS RESEARCH

Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos1

(2014) Kristin M. Whitworth et al.   BIOLOGY OF REPRODUCTION

Brain CD47 expression in a swine model of intracerebral hemorrhage

(2014) Xiang Zhou et al.   BRAIN RESEARCH

Cardiac Repair in a Porcine Model of Acute Myocardial Infarction with Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells

(2014) Lei Ye et al.   Cell Stem Cell

The porcine innate immune system: An update

(2014) K.H. Mair et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Genome-Wide Identification of Long Intergenic Noncoding RNA Genes and Their Potential Association with Domestication in Pigs

(2014) Zhong-Yin Zhou et al.   Genome Biology and Evolution

Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias

(2014) David S. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies

(2014) Dasa Dolezalova et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Measurements of wall shear stress and aortic pulse wave velocity in swine with familial hypercholesterolemia

(2014) Andrew L. Wentland et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Mechanical properties of suspensory fixation devices for anterior cruciate ligament reconstruction: Comparison of the fixed-length loop device versus the adjustable-length loop device

(2014) Akio Eguchi et al.   KNEE

Lessons from rodent models in celiac disease

(2014) N Korneychuk et al.   Mucosal Immunology

Eliminating barriers to personalized medicine: Learning from neurofibromatosis type 1

(2014) D. H. Gutmann   NEUROLOGY

Cohort of birth modifies the association between FTO genotype and BMI

(2014) James Niels Rosenquist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New method of thrombus preparation using a fluid model for evaluation of thrombectomy devices in a swine model

(2014) Qiuji Shao et al.   THROMBOSIS RESEARCH

Novel swine model of transfusion-related acute lung injury

(2014) Hitoshi Okazaki et al.   TRANSFUSION

Divergent immune responses and disease outcomes in piglets immunized with inactivated and attenuated H3N2 swine influenza vaccines in the presence of maternally-derived antibodies

(2014) Matthew R. Sandbulte et al.   VIROLOGY

Lung xenotransplantation: recent progress and current status

(2014) Donald G. Harris et al.   XENOTRANSPLANTATION

Evaluating the Mechanisms of Improved Glucose Homeostasis after Bariatric Surgery in Ossabaw Miniature Swine

(2014) Jonathan G. Sham et al.   Journal of Diabetes Research

Imaging RAGE expression in atherosclerotic plaques in hyperlipidemic pigs

(2014) Lynne L Johnson et al.   EJNMMI Research

Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden

(2013) Elise Gieling et al.   Behavioral and Brain Functions

Gene expression differences during the heterogeneous progression of peripheral atherosclerosis in familial hypercholesterolemic swine

(2013) Martin Bahls et al.   BMC GENOMICS

Structural and functional annotation of the porcine immunome

(2013) Harry D Dawson et al.   BMC GENOMICS

Experimental evaluation of pharmacokinetic profile and biological effect of a novel paclitaxel microcrystalline balloon coating in the iliofemoral territory of swine

(2013) Piotr P. Buszman et al.   CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS

Heart Disease and Stroke Statistics—2014 Update

(2013) Alan S. Go et al.   CIRCULATION

Exercise training and vascular cell phenotype in a swine model of familial hypercholesterolaemia: conduit arteries and veins

(2013) Grant H. Simmons et al.   EXPERIMENTAL PHYSIOLOGY

Comparative Nontargeted Profiling of Metabolic Changes in Tissues and Biofluids in High-Fat Diet-Fed Ossabaw Pig

(2013) Kati Hanhineva et al.   JOURNAL OF PROTEOME RESEARCH

Use of pigs as a potential model for research into dietary modulation of the human gut microbiota

(2013) Sonja N. Heinritz et al.   NUTRITION RESEARCH REVIEWS

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of a bipolar-cooled radiofrequency device for ablation of bone metastases: preclinical assessment in porcine vertebrae

(2013) Padina S. Pezeshki et al.   Spine Journal

Immune response phenotype of allergic versus clinically tolerant pigs in a neonatal swine model of allergy

(2013) Julie Schmied et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Stent healing response following delivery of paclitaxel via durable polymeric matrix versus iopromide-based balloon coating in the familial hypercholesterolaemic swine model of coronary injury

(2013) Piotr P. Buszman et al.   EuroIntervention

Porcine Models of Accelerated Coronary Atherosclerosis: Role of Diabetes Mellitus and Hypercholesterolemia

(2013) Damir Hamamdzic et al.   Journal of Diabetes Research

The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases

(2012) Déborah Bréa et al.   BIOCHEMICAL JOURNAL

Completion of the swine genome will simplify the production of swine as a large animal biomedical model

(2012) Eric M Walters et al.   BMC Medical Genomics

The Role of Complement System in Septic Shock

(2012) Jean Charchaflieh et al.   Clinical & Developmental Immunology

Effect of Human Adipose Derived Stem Cells on Scar Formation and Remodeling in a Pig Model: A Pilot Study

(2012) In Sik Yun et al.   DERMATOLOGIC SURGERY

Brain Growth of the Domestic Pig(Sus scrofa)from 2 to 24 Weeks of Age: A Longitudinal MRI Study

(2012) Matthew S. Conrad et al.   DEVELOPMENTAL NEUROSCIENCE

Drug discovery in pharmaceutical industry: productivity challenges and trends

(2012) Ish Khanna   DRUG DISCOVERY TODAY

The development of swine models in drug discovery and development

(2012) M Michael Swindle   Future Medicinal Chemistry

Genome-Wide DNA Methylation Changes between the Superficial and Deep Backfat Tissues of the Pig

(2012) Mingzhou Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Noncommunicable Diseases

(2012) Shannon L. Marrero et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine

(2012) Stefanie Preuß et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Infection With Cryptosporidium hominis Provides Incomplete Protection of the Host Against Cryptosporidium parvum

(2012) Abhineet Sheoran et al.   JOURNAL OF INFECTIOUS DISEASES

Matrix metalloproteinase-9 expression in carotid atherosclerotic plaque and contrast-enhanced MRI in a swine model

(2012) Xiao-Bing Jiang et al.   Journal of NeuroInterventional Surgery

Adipose-Derived Mesenchymal Stem Cells Enhance Healing of Mandibular Defects in the Ramus of Swine

(2012) Shanna M. Wilson et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Displacement and strain estimation for evaluation of arterial wall stiffness using a familial hypercholesterolemia swine model of atherosclerosis

(2012) Wenqi Ge et al.   MEDICAL PHYSICS

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Analyses of pig genomes provide insight into porcine demography and evolution

(2012) Martien A. M. Groenen et al.   NATURE

Static Autoregulation Is Intact Early After Severe Unilateral Brain Injury in a Neonatal Swine Model

(2012) Jennifer Mytar et al.   NEUROSURGERY

Efficient TALEN-mediated gene knockout in livestock

(2012) D. F. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OCT-Verified Peri-Strut Low-Intensity Areas and the Extent of Neointimal Formation After 3 Years Following Stent Implantation

(2012) Jin-Ho Choi et al.   JACC-Cardiovascular Imaging

The sequence and analysis of a Chinese pig genome

(2012) Xiaodong Fang et al.   GigaScience

Assessing learning and memory in pigs

(2011) Elise Titia Gieling et al.   ANIMAL COGNITION

Comparative fecal metagenomics unveils unique functional capacity of the swine gut

(2011) Regina Lamendella et al.   BMC MICROBIOLOGY

Forecasting the Future of Cardiovascular Disease in the United States

(2011) Paul A. Heidenreich et al.   CIRCULATION

Vascular Response to Zotarolimus-Coated Balloons in Injured Superficial Femoral Arteries of the Familial Hypercholesterolemic Swine

(2011) Juan F. Granada et al.   Circulation-Cardiovascular Interventions

Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia*

(2011) Jennifer K. Lee et al.   CRITICAL CARE MEDICINE

Gastrointestinal infection as a trigger for inflammatory bowel disease

(2011) Elizabeth A. Mann et al.   CURRENT OPINION IN GASTROENTEROLOGY

The cost of drug development: A systematic review

(2011) Steve Morgan et al.   HEALTH POLICY

Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: Preface

(2011) Naoki Kaneko et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Lymphoid Neoplasms in Swine

(2011) Kikumi OGIHARA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Mouse and human intestinal immunity: same ballpark, different players; different rules, same score

(2011) D L Gibbons et al.   Mucosal Immunology

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Predictive models for pressure-driven fluid infusions into brain parenchyma

(2011) Raghu Raghavan et al.   PHYSICS IN MEDICINE AND BIOLOGY

Gene expression differences in healthy brachial and femoral arteries of Rapacz familial hypercholesterolemic swine

(2011) Martin Bahls et al.   PHYSIOLOGICAL GENOMICS

Analysis of DNA Methylation in Various Swine Tissues

(2011) Chun Yang et al.   PLoS One

Lactobacillus rhamnosus HN001 Attenuates Allergy Development in a Pig Model

(2011) Debra J. Thomas et al.   PLoS One

Long noncoding RNA in genome regulation

(2011) Tiffany Hung et al.   RNA Biology

Strategies for regeneration of the bone using porcine adult adipose-derived mesenchymal stem cells

(2011) E. Monaco et al.   THERIOGENOLOGY

Disruption of the Survival Motor Neuron (SMN) gene in pigs using ssDNA

(2011) Monique A. Lorson et al.   TRANSGENIC RESEARCH

Autoimmune Sensitization to Cardiac Myosin Leads to Acute Rejection of Cardiac Allografts in Miniature Swine

(2011) Gregory R. Veillette et al.   TRANSPLANTATION

The pig: a model for human infectious diseases

(2011) François Meurens et al.   TRENDS IN MICROBIOLOGY

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

Correlation of Angiographic Late Loss With Neointimal Proliferation in Stents Evaluated by OCT and Histology in Porcine Coronary Arteries

(2011) Jung-Sun Kim et al.   JACC-Cardiovascular Imaging

In vivo intravascular ultrasound analysis of the absorption rate of the Angio-Seal™ vascular closure device in the porcine femoral artery

(2011) Armando Tellez et al.   EuroIntervention

Paclitaxel-iopromide coated balloon followed by “bail-out” bare metal stent in porcine iliofemoral arteries: first report on biological effects in peripheral circulation

(2011) Krzysztof Milewski et al.   EuroIntervention

Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host

(2011) Michael John Brady et al.   Frontiers in Microbiology

Ultrasound-Enhanced Drug Transport and Distribution in the Brain

(2010) Ying Liu et al.   AAPS PHARMSCITECH

Solitaire Flow-Restoration Device for Treatment of Acute Ischemic Stroke: Safety and Recanalization Efficacy Study in a Swine Vessel Occlusion Model

(2010) R. Jahan   AMERICAN JOURNAL OF NEURORADIOLOGY

Concept of Vulnerable/Unstable Plaque

(2010) Aloke V. Finn et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Coronary bare metal stent implantation in homozygous LDL receptor deficient swine induces a neointimal formation pattern similar to humans

(2010) Armando Tellez et al.   ATHEROSCLEROSIS

Pharmaceutical Innovation in the 21st Century: New Drug Approvals in the First Decade, 2000–2009

(2010) K I Kaitin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pig cognition

(2010) Michael Mendl et al.   CURRENT BIOLOGY

Glucose Intolerance and Reduced Proliferation of Pancreatic  -Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function

(2010) S. Renner et al.   DIABETES

A Piglet Model of Acute Gastroenteritis Induced byShigella dysenteriaeType 1

(2010) Kwang‐il Jeong et al.   JOURNAL OF INFECTIOUS DISEASES

Swine Influenza H1N1 Virus Induces Acute Inflammatory Immune Responses in Pig Lungs: a Potential Animal Model for Human H1N1 Influenza Virus

(2010) M. Khatri et al.   JOURNAL OF VIROLOGY

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research

(2010) Birgitte R. Kornum et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Nutritional programming of gastrointestinal tract development. Is the pig a good model for man?

(2010) Paul Guilloteau et al.   NUTRITION RESEARCH REVIEWS

Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

(2010) D. A. Stoltz et al.   Science Translational Medicine

Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs

(2010) Aleksandar Masic et al.   VACCINE

Accuracy of Optical Coherence Tomography in the Evaluation of Neointimal Coverage After Stent Implantation

(2010) Akira Murata et al.   JACC-Cardiovascular Imaging

Porcine models of coronary atherosclerosis and vulnerable plaque for imaging and interventional research

(2010) Juan Granada et al.   EuroIntervention

Genetic management of the Göttingen Minipig population

(2010) Henner Simianer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Lipid Emulsion Combined with Epinephrine and Vasopressin Does Not Improve Survival in a Swine Model of Bupivacaine-induced Cardiac Arrest

(2009) Shawn D. Hicks et al.   ANESTHESIOLOGY

The pig model in brain imaging and neurosurgery

(2009) P. Sauleau et al.   Animal

Characterization of Conserved and Nonconserved Imprinted Genes in Swine1

(2009) Steve R. Bischoff et al.   BIOLOGY OF REPRODUCTION

Animal Models to Study Environmental Epigenetics1

(2009) Cheryl S. Rosenfeld   BIOLOGY OF REPRODUCTION

Animal models to study neonatal nutrition in humans

(2009) Patrycja Puiman et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Swine leukocyte antigen (SLA) diversity in Sinclair and Hanford swine

(2009) Chak-Sum Ho et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Piglet Models of Acute or ChronicClostridium difficileIllness

(2009) Jennifer Steele et al.   JOURNAL OF INFECTIOUS DISEASES

The Impact of Obesity on Health Service Utilization and Costs in Childhood

(2009) Leonardo Trasande et al.   Obesity

Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses

(2009) I. Amit et al.   SCIENCE

Barbed Suture for Gastrointestinal Closure: A Randomized Control Trial

(2009) Sebastian V Demyttenaere et al.   Surgical Innovation

The porcine lung as a potential model for cystic fibrosis

(2008) Christopher S. Rogers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Drug-Eluting Stents in Preclinical Studies

(2008) Robert S. Schwartz et al.   Circulation-Cardiovascular Interventions

Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?

(2008) Alex Dyson et al.   CRITICAL CARE MEDICINE

Permeability of hyperosmotic agent in normal and atherosclerotic vascular tissues

(2008) Mohamad G. Ghosn et al.   JOURNAL OF BIOMEDICAL OPTICS

Development of a real-time PCR method forFirmicutesandBacteroidetesin faeces and its application to quantify intestinal population of obese and lean pigs

(2008) X. Guo et al.   LETTERS IN APPLIED MICROBIOLOGY

Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease

(2008) Sanjay Sethi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Animal Models in Pancreatic Surgery: A Plea for Pork

(2008) Mark J. Truty et al.   PANCREATOLOGY

Epigenetics and obesity

(2008) Reinhard Stöger   PHARMACOGENOMICS

Genomic imprinting effects on adult body composition in mice

(2008) J. M. Cheverud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Mammals and Their Gut Microbes

(2008) R. E. Ley et al.   SCIENCE

Thrombelastography is Better Than PT, aPTT, and Activated Clotting Time in Detecting Clinically Relevant Clotting Abnormalities After Hypothermia, Hemorrhagic Shock and Resuscitation in Pigs

(2008) Wenjun Z. Martini et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE