Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

(2014) C. Benedikt Westphalen et al.   JOURNAL OF CLINICAL INVESTIGATION

Drugging a Stem Cell Compartment Using Wnt3a Protein as a Therapeutic

(2014) Girija R. Dhamdhere et al.   PLoS One

A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding

(2014) Annabelle Lewis et al.   Cell Reports

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

(2013) Felipe De Sousa E Melo et al.   NATURE MEDICINE

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

(2012) Emma Jaeger et al.   NATURE GENETICS

Reply to "The classification of intestinal polyposis"

(2012) Ian Tomlinson et al.   NATURE GENETICS

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

A comprehensive review of reported heritable noggin-associated syndromes and proposed clinical utility of one broadly inclusive diagnostic term: NOG-related-symphalangism spectrum disorder (NOG-SSD)

(2011) Tommy A. Potti et al.   HUMAN MUTATION

Sessile Serrated Adenoma (SSA) vs. Traditional Serrated Adenoma (TSA)

(2009) Emina Emilia Torlakovic et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Autophagy in tumour suppression and promotion

(2009) Andreas Brech et al.   Molecular Oncology

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Current View: Intestinal Stem Cells and Signaling

(2008) David H. Scoville et al.   GASTROENTEROLOGY

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

(2008) Stefania Segditsas et al.   HUMAN MOLECULAR GENETICS

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE