Article
Clinical Neurology
Hatice Eraslan Boz, Koray Kocoglu, Muege Akkoyun, Isil Yagmur Tufekci, Merve Ekin, Guelden Akdal
Summary: The study found that visual search impairment exists in early stages of both AD and aMCI, highlighting the importance of addressing visual processes in the Alzheimer's continuum.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cell Biology
Ying-Ren Chen, Chih-Sung Liang, Hsin Chu, Joachim Voss, Xiao Linda Kang, Grant O'Connell, Hsiu-Ju Jen, Doresses Liu, Shu-Tai Shen Hsiao, Kuei-Ru Chou
Summary: Blood-based biomarkers have shown high diagnostic accuracy for detecting Alzheimer's disease, with plasma A beta 42, A beta oligomer, and plasma tau demonstrating good sensitivity and specificity. However, evidence for detecting amnestic mild cognitive impairment using blood-based biomarkers is still limited. Ultra-high sensitive technology can help explain the heterogeneity in diagnostic performance.
AGEING RESEARCH REVIEWS
(2021)
Article
Neurosciences
Haichao Zhao, Jian Cheng, Tao Liu, Jiyang Jiang, Forrest Koch, Perminder S. Sachdev, Peter J. Basser, Wei Wen
Summary: White matter abnormalities, such as orientational changes in specific fiber tracts, were found to be prominent in Alzheimer's disease patients compared to cognitively normal individuals. In contrast, individuals with amnestic mild cognitive impairment showed subtle changes in specific fiber tracts that were associated with cognitive performance. These findings suggest that white matter fiber orientation information could offer valuable insights into the pathology of neurodegenerative diseases like Alzheimer's disease.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Xiaomei Zhong, Ben Chen, Le Hou, Qiang Wang, Meiling Liu, Mingfeng Yang, Min Zhang, Huarong Zhou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning
Summary: This study aimed to compare temporal variability in the spontaneous fluctuations of activity and connectivity between amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The results showed that both aMCI and naMCI patients exhibited abnormal brain activity and connectivity. The variability in dALFF, dReHo, and hippocampal dFC was different between aMCI and naMCI patients and was associated with cognitive scores. The dReHo of the superior parietal lobule and dFC of the hippocampus-cerebellum contributed to the memory heterogeneity of MCI subtypes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Xiaotong Wei, Xiaotong Du, Yingying Xie, Xinjun Suo, Xiaoxi He, Hao Ding, Yu Zhang, Yi Ji, Chao Chai, Meng Liang, Chunshui Yu, Yong Liu, Wen Qin
Summary: By mapping the region-specific nonlinear atrophic trajectory of the whole cerebrum from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD), this study found that the atrophic trajectory is quadratic accelerated, especially in the superior temporal pole, caudate, and hippocampus. Furthermore, the study revealed that APOE ε4 carriers and younger patients had faster atrophic rates in specific regions. Lastly, the identified region-specific biomarkers were able to predict AD conversion within 10 years.
Article
Immunology
Wenjuan Rui, Hong Xiao, Yi Fan, Zhongxuan Ma, Ming Xiao, Sheng Li, Jingping Shi
Summary: The study revealed that canonical inflammasome signaling and GSDMD-induced pyroptosis were activated in PBMCs of aMCI and AD patients. Additionally, the proinflammatory cytokine IL-1 beta was strongly associated with the pathophysiology of aMCI and AD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Geriatrics & Gerontology
Eun Jin Yoon, Jun-Young Lee, Seyul Kwak, Yu Kyeong Kim
Summary: Mild behavioral impairment (MBI) is a neurobehavioral syndrome associated with a higher risk of progression to Alzheimer's disease (AD) in individuals with amnestic mild cognitive impairment (MCI). The presence of multiple MBI domains is also associated with cortical thinning in specific brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Article
Clinical Neurology
Dan Li, Yue-Yi Yu, Nan Hu, Min Zhang, Li Liu, Li-Mei Fan, Shi-Shuang Ruan, Fen Wang
Summary: This study compared the reliability and validity of the color-picture version of BNT (CP-BNT) and the black-and-white version of BNT (BW-BNT) in differentiating amnestic mild cognitive impairment (aMCI) or mild Alzheimer's disease (AD) from cognitive normals. The results showed that CP-BNT outperformed BW-BNT in terms of diagnostic accuracy and reliability.
FRONTIERS IN NEUROLOGY
(2022)
Review
Behavioral Sciences
Yi Qu, Ya-Hui Ma, Yu-Yuan Huang, Ya-Nan Ou, Xue-Ning Shen, Shi-Dong Chen, Qiang Dong, Lan Tan, Jin-Tai Yu
Summary: Blood-based biomarkers of AD pathology show significant changes between AD, aMCI, and control groups, indicating their strong validity in identifying AD and aMCI, and providing a new prospect for early diagnosis and monitoring of AD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Yirong He, Qiongling Li, Zhenrong Fu, Debin Zeng, Ying Han, Shuyu Li
Summary: Using connectome gradient mapping, we investigated the altered topological organization in amnestic mild cognitive impairment and Alzheimer's disease. Our results showed that Alzheimer's disease patients exhibited a more distributed and significant suppression of the neocortical hierarchy gradient, while this alteration was limited to limbic areas in amnestic mild cognitive impairment patients. Furthermore, we found that gradient dispersion was associated with cognitive scores in both patient groups, providing new evidence for altered brain hierarchy in these conditions.
Article
Clinical Neurology
Yuting Nie, Changbiao Chu, Qi Qin, Huixin Shen, Lulu Wen, Yi Tang, Miao Qu
Summary: This study identified significant differences in lipid metabolism between Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) patients compared to normal controls (NC). Three sphingomyelin (SPH) biomarkers were found to effectively distinguish AD and aMCI patients from NC. Additionally, AD patients exhibited elevated oxidative stress, and there were complex interactions between lipid metabolites and oxidative stress.
Article
Clinical Neurology
Shiloh L. Echevarria-Cooper, Emily H. Ho, Richard C. Gershon, Sandra Weintraub, Thorsten Kahnt
Summary: Olfactory decline is associated with aging, amnestic mild cognitive impairment (aMCI), and Alzheimer's disease dementia. The National Institutes of Health Toolbox Odor Identification Test (NIHTB-OIT) can distinguish between these clinical categories. The scores of NIHTB-OIT decrease with age and are lower for aMCI and ADd participants compared to NC participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Erin E. Sundermann, Lisa L. Barnes, Mark W. Bondi, David A. Bennett, David P. Salmon, Pauline M. Maki
Summary: This study found that sex-adjusted norms improve diagnostic accuracy for aMCI, avoiding diagnostic errors. The risk of false negative in women and false positive in men is significantly higher than expected.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Joseph M. Gullett, Alejandro Albizu, Ruogu Fang, David A. Loewenstein, Ranjan Duara, Monica Rosselli, Melissa J. Armstrong, Tatjana Rundek, Hanna K. Hausman, Steven T. Dekosky, Adam J. Woods, Ronald A. Cohen
Summary: This study successfully predicted the conversion to dementia in high-risk aMCI patients based on baseline data using multimodal MRI, and identified brain regions associated with long-term decline to dementia. By combining T1 MRI and rsfMRI modalities and using SVM classification, a high prediction accuracy was achieved.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ilaria Zuliani, Chiara Lanzillotta, Antonella Tramutola, Antonio Francioso, Sara Pagnotta, Eugenio Barone, Marzia Perluigi, Fabio Di Domenico
Summary: Protein O-GlcNAcylation plays a crucial role in neurodegenerative diseases, particularly in the pathogenesis of Alzheimer's disease. Although Down syndrome (DS) and AD share similar pathological features, the impact of O-GlcNAcylation in DS pathology has not been investigated. This study sheds light on the role of O-GlcNAcylation in DS brain alterations and its significance in AD hallmarks.
Article
Biochemistry & Molecular Biology
Chiara Lanzillotta, Antonella Tramutola, Graziella Di Giacomo, Federico Marini, D. Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Summary: Research has shown that Down syndrome shares many common features with early onset Alzheimer's disease, including defects in brain insulin resistance, oxidative stress, and protein activation status in synaptic plasticity mechanisms. These abnormalities appear early in DS model mice, which may contribute to the development of AD in DS.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Chiara Lanzillotta, Fabio Di Domenico
Summary: Down syndrome is characterized by early onset Alzheimer's disease due to triplication of genes on chromosome 21, leading to oxidative stress and protein oxidation. Therapeutic approaches targeting antioxidant response and protein stability have shown efficacy in murine models, but further studies are needed for clinical translation.
Article
Biochemistry & Molecular Biology
Ilaria Zuliani, Chiara Lanzillotta, Antonella Tramutola, Eugenio Barone, Marzia Perluigi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzola, Francesco Bellanti, Matteo Spinelli, Francesca Natale, Salvatore Fusco, Claudio Grassi, Fabio Di Domenico
Summary: This study reveals that aberrant protein O-GlcNAcylation plays a significant role in the neurodegenerative process induced by a high-fat diet, potentially promoting the development of Alzheimer's disease and mitochondrial impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
M. Perluigi, F. Di Domenico, E. Barone, D. A. Butterfield
Summary: Alzheimer's disease (AD) is the most common form of dementia in the elderly, with aberrant mTOR signaling potentially leading to cognitive decline and increased oxidative stress, impacting disease progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Marzia Perluigi, Anna Picca, Elita Montanari, Riccardo Calvani, Federico Marini, Roberto Matassa, Antonella Tramutola, Alberto Villani, Giuseppe Familiari, Fabio Di Domenico, D. Allan Butterfield, Kenneth J. Oh, Emanuele Marzetti, Diletta Valentini, Eugenio Barone
Summary: The study found that nEVs isolated from DS children showed a significant increase in insulin resistance marker pIRS1(Ser636) and hyperactivation of the Akt/mTOR/p70S6K pathway downstream from IRS1, possibly driven by higher inhibition of PTEN. Additionally, high levels of pGSK3 beta(Ser9) were also observed. These alterations in the insulin-signaling/mTOR pathways are believed to be early events in the DS brain, contributing to the cognitive dysfunction and intellectual disability seen in this unique population.
ALZHEIMERS & DEMENTIA
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
D. Allan Butterfield, Eugenio Barone, Fabio Di Domenico, Marzia Perluigi
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Eugenio Barone, Fabio Di Domenico, Marzia Perluigi, D. Allan Butterfield
Summary: The article discusses the potential relationship between type 2 diabetes and Alzheimer's disease, highlighting the roles of oxidative stress, insulin resistance, and AMPK dysfunction in neurodegenerative disorders.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sara Pagnotta, Antonella Tramutola, Eugenio Barone, Fabio Di Domenico, Valeria Pittala, Loredana Salerno, Valentina Folgiero, Matteo Caforio, Franco Locatelli, Stefania Petrini, D. Allan Butterfield, Marzia Perluigi
Summary: This study focuses on the role of BACH1/NRF2 ratio in the regulation of antioxidant response and its impact on patients with Down syndrome. The results show that overexpression of BACH1 disrupts the induction of antioxidant response genes, leading to oxidative damage accumulation. Additionally, administration of CAPE and VP961 promotes NRF2 nuclear translocation in cells from Down syndrome patients, improving antioxidant response.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Chiara Lanzillotta, Antonella Tramutola, Fabio Di Domenico, Bindu Paul, Solomon Snyder, D. Allan Butterfield, Marzia Perluigi, Joao Duarte, Eugenio Barone
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Fabio Di Domenico, Chiara Lanzillotta, Eugenio Barone, Antonella Tramutola, Marzia Perluigi
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Antonella Tramutola, Sara Pagnotta, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Neurosciences
Chiara Urbinati, Chiara Lanzillotta, Livia Cosentino, Daniela Valenti, Maria Cristina Quattrini, Livia Di Crescenzo, Francesca Prestia, Donatella Pietraforte, Marzia Perluigi, Fabio Di Domenico, Rosa Anna Vacca, Bianca De Filippis
Summary: Metformin treatment can selectively correct cognitive flexibility defects, improve mitochondrial function, and inhibit oxidative stress in female mice with Rett syndrome (RTT). However, it does not affect the general health and motor skills of RTT mice.
Article
Biochemistry & Molecular Biology
Antonella Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta, Gabriele Ruffolo, Pierangelo Cifelli, Federico Marini, Cristian Ripoli, Eleonora Palma, Claudio Grassi, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Summary: Down syndrome (DS) is associated with Alzheimer's disease (AD) and brain insulin resistance. The KYCCSRK peptide has shown potential for improving insulin signaling in DS and reducing AD-like neuropathology in mice.
Meeting Abstract
Biochemistry & Molecular Biology
Fabio Di Domenico
FREE RADICAL BIOLOGY AND MEDICINE
(2022)