Article
Biochemistry & Molecular Biology
Javaria Baig, Neha Sawant, Priyanka Rawat, Arubala P. Reddy, P. Hemachandra Reddy, Sudhir Kshirsagar
Summary: Alzheimer's disease is a common neurodegenerative disease, and RalBP1 protein plays an important role in it. Mutations in APP and Tau proteins interact with the Rlip protein, leading to decreased Rlip function.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yuki Kobayashi, Shogo Kohbuchi, Noriko Koganezawa, Yuko Sekino, Tomoaki Shirao, Takaomi C. Saido, Takashi Saito, Yumiko Saito
Summary: The primary cilium, a sensory organelle extending from cell bodies, plays a crucial role in neuronal integrity and connectivity. Research suggests a potential link between the structural alterations of neuronal cilia and the development of Alzheimer's disease and ciliopathies, which are characterized by memory and cognitive impairments.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Ferdous Taslima, Cha-Gyun Jung, Chunyu Zhou, Mona Abdelhamid, Mohammad Abdullah, Tetsuya Goto, Takashi Saito, Takaomi C. Saido, Makoto Michikawa
Summary: Tooth loss induces memory impairment through an amyloid-cascade-independent pathway, decreases neuronal activity and synaptic protein levels in the cortex and hippocampus, and activates glial cells leading to upregulation of neuroinflammatory cytokines. Moreover, tooth loss activates stress-activated protein kinase JNK and increases HSP90 levels in the hippocampus, potentially contributing to glial activation. Throughout, taking care of teeth is emphasized to maintain a healthy oral environment and reduce the risk of cognitive dysfunction.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Luana Naia, Makoto Shimozawa, Erika Bereczki, Xidan Li, Jianping Liu, Richeng Jiang, Romain Giraud, Nuno Santos Leal, Catarina Moreira Pinho, Erik Berger, Victoria Lim Falk, Giacomo Dentoni, Maria Ankarcrona, Per Nilsson
Summary: This study investigates the sequential onset of AD-like pathologies in App knock-in mice and reveals that energy metabolism is significantly altered at an early stage of pathology. As the pathology progresses, the brain shifts to a state of hypometabolism and synaptic abnormalities occur, including accumulation of synaptic vesicles and autophagosomes.
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Yan Gao, Juntong Li, Qinglin Wu, Shasha Wang, Songwei Yang, Xun Li, Naihong Chen, Lin Li, Lan Zhang
Summary: TSG effectively alleviated Aβ-induced cytotoxicity in neuronal cells within APP/PS1 mice by regulating ferroptosis related proteins and enzymes, promoting activation of several antioxidative pathways, and reducing oxidative stress and inflammation levels. These findings highlight a novel mechanism of TSG in reversing Aβ-induced injury, suggesting its potential as a promising candidate in the treatment of neurodegenerative diseases, especially AD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Liangyun Liu, Jianing Cao, Chujun Huang, Erdong Yuan, Jiaoyan Ren
Summary: Cognitive impairment is a major clinical feature in AD patients, but research suggests peripheral organs may also play a role in AD pathology. Studies on aged APP/PS1 mice show increased inflammation response and decreased anti-oxidative capacity in peripheral organs, highlighting the need for a more comprehensive approach to studying AD.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Cell & Tissue Engineering
Hao-Han Guo, Lei Xiong, Jin-Xiu Pan, Daehoon Lee, Kevin Liu, Xiao Ren, Bo Wang, Xiao Yang, Shun Cui, Lin Mei, Wen-Cheng Xiong
Summary: This study found that increased levels of hepcidin in AD model mice Tg2576 may lead to decreased bone mass, identifying a potential therapeutic target for preventing AD-associated bone loss.
Article
Cell Biology
Jin-Xiu Pan, Daehoon Lee, Dong Sun, Kai Zhao, Lei Xiong, Hao-Han Guo, Xiao Ren, Peng Chen, Raquel Lopez de Boer, Yuyi Lu, Helena Lin, Lin Mei, Wen-Cheng Xiong
Summary: Alzheimer's disease (AD) patients often suffer from severe sarcopenia. This study using transgenic mice found that the expression of APP(swe) in skeletal muscles leads to systemic and hippocampal inflammation, deficits in neurogenesis and blood-brain barrier, and depression-like behaviors, revealing a link between sarcopenia and AD, as well as an axis of muscular APP(swe) to brain in AD development.
CELL DEATH & DISEASE
(2022)
Article
Geriatrics & Gerontology
Zachery. D. D. Morrissey, Jin Gao, Liang Zhan, Weiguo Li, Igor Fortel, Takaomi Saido, Takashi Saito, Arnold Bakker, Scott Mackin, Olusola Ajilore, Orly Lazarov, Alex. D. D. Leow
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disease. The early processes of AD are not fully understood but disruption of the default mode network, including the hippocampus, has been implicated. This study used a mouse model to examine functional network connectivity changes in the early stages of AD and found that there are early changes in hippocampal connectivity prior to the heavy onset of amyloid beta plaques, which may serve as an early biomarker of AD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biology
Mayumi Minamisawa, Yuma Sato, Eitarou Ishiguro, Tetsuyuki Taniai, Taiichi Sakamoto, Gota Kawai, Takashi Saito, Takaomi C. Saido
Summary: This study observed disease progression, changes in the gut microbiota, and interactions among the brain, liver, pancreas, and intestine in a mouse model of Alzheimer's disease (AD), and found that L-arginine and limonoids help in maintaining the homeostasis of these organs in AD mice.
Review
Biochemistry & Molecular Biology
Jana Tchekalarova, Rumiana Tzoneva
Summary: Aging and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are linked by common features like mitochondrial dysfunction and protein aggregation. The rising costs of caring for elderly patients with these diseases is a major issue in today's demographic crisis. Oxidative stress and imbalanced antioxidant defense system play crucial roles in age-related neurodegeneration, and diminished melatonin release with aging further increases susceptibility to these diseases. Understanding the underlying mechanisms and melatonin's role is important for developing precise treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yasufumi Sakakibara, Yu Hirota, Kyoko Ibaraki, Kimi Takei, Sachie Chikamatsu, Yoko Tsubokawa, Takashi Saito, Takaomi C. Saido, Michiko Sekiya, Koichi M. Iijima
Summary: In aged App(NL-G-F/NL-G-F) knock-in mice, cortical A beta pathology induced significant reduction in the density of noradrenergic axons from the locus coeruleus, without neuron loss or tau pathology, suggesting a mechanism of noradrenergic neurodegeneration in Alzheimer's disease. Further investigation is needed to uncover the underlying mechanisms and develop effective therapeutics to halt AD progression.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemical Research Methods
Nalini R. Rao, Jeffrey N. Savas
Summary: This study demonstrates that chronic treatment with levetiracetam can normalize levels of presynaptic endocytic proteins and alter APP cleavage preference, leading to a decrease in both A beta(42) levels and the amyloid plaque burden in APP knock-in mouse models of amyloid pathology. These findings suggest the therapeutic potential of levetiracetam in mitigating AD pathology.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Cell Biology
Guianfranco Mazzei, Ryohei Ikegami, Nona Abolhassani, Naoki Haruyama, Kunihiko Sakumi, Takashi Saito, Takaomi C. Saido, Yusaku Nakabeppu
Summary: The study found that high-fat diet caused cognitive impairment, increased A beta deposition, and microgliosis in transgenic mouse models of Alzheimer's disease, accompanied by insulin resistance in the hippocampus.
Article
Geriatrics & Gerontology
Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein, Bengt Winblad, Nenad Bogdanovic, Per Nilsson
Summary: Alzheimer's disease is characterized by impaired protein homeostasis leading to amyloid-beta peptide amyloidosis. In this study, the researchers compared AD postmortem brain tissue with brains from App knock-in mice and found that p62 levels were increased in both. Additionally, the App knock-in mice exhibited inhibited autophagy, especially when A beta pathology was increased. These findings suggest that the App knock-in mouse models can help understand the correlation between A beta and autophagy.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)