Article
Biochemistry & Molecular Biology
Andrew Stiegler, Jian-Hua Li, Vivek Shah, Tea Tsaava, Aisling Tynan, Huan Yang, Yehuda Tamari, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Summary: Acetylcholine (ACh) produced by T-cell subset expressing ChAT regulates blood pressure by stimulating nitric oxide-dependent vasodilation. Increasing systemic ChAT concentrations through recombinant or PEG-modified ChAT decreased blood pressure significantly in hypertensive mice. This suggests the potential role of ChAT in hypertension warrants further studies.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lisa-Marie Wackernagel, Mohsen Abdi Sarabi, Sonke Weinert, Werner Zuschratter, Karin Richter, Klaus Dieter Fischer, Ruediger C. Braun-Dullaeus, Senad Medunjanin
Summary: The NF-κB pathway plays a central role in inflammatory and immune responses, and the activation of NF-κB is dependent on IKK gamma/NEMO. This study reveals that GSK-3 beta phosphorylates NEMO, leading to its localization into multivesicular bodies (MVBs) and endosomes. The AAA-ATPase Vps4A is identified as a key player in NEMO stability and NF-κB activation, interacting directly with phosphorylated NEMO. Manipulation of Vps4A expression results in changes in NEMO expression and NF-κB activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fangping Xiao, Lei Wang, Meng Liu, Mingyue Chen, Hao He, Zhiqiang Jia, Lai Zhang, Yaqing Yang, Qianfan Hu, Mei Hong, Hanwen Zhang
Summary: In this study, the therapeutic role of SAC/VAL in regulating the GSK3β/NF-κB signaling pathway to suppress the inflammatory response and apoptosis was reported. SAC/VAL was found to reduce infarct size, improve ventricular function, and reverse pathological ventricular remodeling in I/R injury.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Article
Biochemistry & Molecular Biology
Nguyen Khanh Toan, Nguyen Chi Tai, Soo-A Kim, Sang-Gun Ahn
Summary: The study showed that aging led to a significant decrease in salivary secretion in SAMP1/Klotho -/- mice, accompanied by a decrease in acetylcholine levels and reduction in ChAT expression. Overexpression of ChAT increased the expression of salivary gland functional markers and saliva secretion in both +/+ and -/- mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Veronica Corsetti, Carla Perrone-Capano, Michael Sebastian Salazar Intriago, Elisabetta Botticelli, Giancarlo Poiana, Gabriella Augusti-Tocco, Stefano Biagioni, Ada Maria Tata
Summary: The study revealed the expression of multiple ChAT and VAChT splice variants in rat DRG neurons, showing a progressive decrease during development. ChAT levels significantly increased during DRG ontogenesis, indicating an important role for ACh in neuronal differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng, Weina Yang
Summary: This study demonstrates that tanshinone IIA (tan IIA) can ameliorate cognitive decline and tau pathology in APP/PS1 mice by modulating the PI3K/Akt/GSK-3β signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohammed M. H. Al-Gayyar, Abdullah Alattar, Reem Alshaman, Ahmed M. Hamdan
Summary: Inhibition of NF kappa B and TNF-alpha by QNZ in HCC showed therapeutic effects in rats, including reduced tumor markers, increased survival rate, and improved hepatocyte structure. Additionally, QNZ treatment decreased the expression of TRAF, ASK-1, and beta-catenin while increasing the expression of GSK-3, which are associated with tumor growth and progression.
Article
Multidisciplinary Sciences
Long He, Jennifer Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis
Summary: Serine/one-carbon metabolism plays a critical role in cancer cell growth, but the regulatory mechanisms are not well understood. This study reveals that glycogen synthase kinase 3 (GSK3) plays a key role in regulating the expression of serine/one-carbon metabolic enzymes. Inhibition of nuclear GSK3 signaling enhances the efficacy of serine/one-carbon metabolism inhibitors in suppressing cancer cell proliferation.
Review
Biochemistry & Molecular Biology
Divya M. Teli, Anuradha K. Gajjar
Summary: Elevated glucose level due to β-cell dysfunction is a key marker of Type-II diabetes. GSK-3, an enzyme involved in glycogen metabolism control, has been explored for its potential as a target for diabetes treatment. This review article examines the structural analysis and molecular modeling of GSK-3, as well as advancements in the development of GSK-3 inhibitors as potential therapeutics for Type II diabetes.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
David L. Brautigan
Summary: Glycogen is a polymerized form of glucose used as an energy reserve in organisms. The synthesis and degradation of glycogen in animals, especially in the liver and skeletal muscle, is regulated by hormones and physiological signals that control the activities of glycogen synthase and glycogen phosphorylase. This article discusses the flash activation of phosphorylase in glycogen particles and suggests that the regulation of phosphatase in glycogen particles may involve hybrids of phosphorylase.
Article
Environmental Sciences
Dalia H. El-Kashef, Maha H. Sharawy
Summary: Nicorandil protects against acetaminophen-induced liver damage by reducing liver function indicators, inhibiting oxidative stress and inflammation, and improving cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Genetics & Heredity
Juanjuan Liu, Shanshan Gao, Luting Wei, Wenfeng Xiong, Yaoyao Lu, Xiaowen Song, Yonglei Zhang, Han Gao, Bin Li
Summary: This study investigates the functions of choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) in insect development, reproduction, and insecticide susceptibility. The researchers found that RNA interference of Chat and vacht in Tribolium castaneum resulted in decreased acetylcholine content and disrupted larval development and pupal eclosion. Knockdown of these enzymes also reduced fecundity and egg hatchability. Additionally, the researchers observed that the transcript levels of chat and vacht increased after treatment with carbofuran or dichlorvos, and reduction of chat or vacht decreased the resistance to these insecticides.
Review
Immunology
Namrita Halder, Girdhari Lal
Summary: Neurological and immunological signals interact to maintain homeostasis in the body. The cholinergic system plays a crucial role in neuroimmune communication, regulating immune response. Various molecules of the neuronal and non-neuronal cholinergic system interact to modulate inflammation and immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Aamir Mushtaq, Rukhsana Anwar, Umar Farooq Gohar, Mobasher Ahmad, Romina Alina Marc (Vlaic), Crina Carmen Muresan, Marius Irimie, Elena Bobescu
Summary: This study investigated the memory-enhancing properties of Lavandula Stoechas L. The active fraction AfL.s of the plant showed improvement in memory retention behavior in mice and positive effects on biochemical parameters in the brain. However, high doses of AfL.s resulted in hyperactivity and death in mice.
Article
Cell Biology
Dan Zhang, Song Han, Shizun Wang, Yanlin Luo, Li Zhao, Junfa Li
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2017)
Article
Endocrinology & Metabolism
Jiayin Zheng, Yue Wang, Song Han, Yanlin Luo, Xiuli Sun, Ning Zhu, Li Zhao, Junfa Li
JOURNAL OF DIABETES RESEARCH
(2018)
Article
Neurosciences
Li Zhao, Xu Liu, Jing Liang, Song Han, Yue Wang, Yanling Yin, Yanlin Luo, Junfa Li
Article
Neurosciences
L. Zhao, C. -B. Chu, J. -F. Li, Y. -T. Yang, S. -Q. Niu, W. Qin, Y. -G. Hao, Q. Dong, R. Guan, W. -L. Hu, Y. Wang
Article
Medicine, Research & Experimental
Yue Wang, Qian Dong, Yu-dan Chen, Wen-li Hu, Li Zhao
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Neurosciences
Jiayin Zheng, Yue Wang, Yue Liu, Song Han, Ying Zhang, Yanlin Luo, Yi Yan, Junfa Li, Li Zhao
Summary: This study found that knockout of cPKCγ in the hippocampal neurons of T1DM mice increased the phosphorylation of Tau at Ser214 and neurofibrillary tangles. cPKCγ deficiency reduced autophagy levels and cognitive impairment in T1DM mice. cPKCγ promotes autophagy through the AMPK/mTOR signaling pathway, reducing the phosphorylation of Tau at Ser214 and neurofibrillary tangles.
NEUROSCIENCE BULLETIN
(2022)
Article
Medicine, Research & Experimental
Yue Liu, Yuan Yuan, Yi Yan, Ruyue Wang, Zhaohui Wang, Xiao Liu, Ying Zhang, Jianyu Hua, Yue Wang, Li Zhao
Summary: This research aims to investigate the impact of mitochondrial dysfunction on cerebral ischemia and explore the role of mitochondrial pyruvate carrier 1 (MPC1) in this process. The study demonstrates that MPC1 can exert a neuroprotective effect on cerebral ischemia by attenuating oxidative stress, mitochondrial dysfunction, calcium overload, and autophagy. The findings suggest that MPC1-related genes identified through RNA-seq may serve as a novel therapeutic target for cerebral ischemia.
