Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis

Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial

(2016) Junaidah B Barnett et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Zinc transporter Slc39a14 regulates inflammatory signaling associated with hypertrophic adiposity

(2016) Catalina Troche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Properties of Zip4 accumulation during zinc deficiency and its usefulness to evaluate zinc status: a study of the effects of zinc deficiency during lactation

(2016) Ayako Hashimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Zinc transporters and signaling in physiology and pathogenesis

(2016) Shintaro Hojyo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

(2016) K. M. Taylor et al.   BIOCHEMICAL JOURNAL

The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation

(2016) S. Fujimoto et al.   BIOCHEMICAL JOURNAL

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition

(2016) Dalin Li et al.   GASTROENTEROLOGY

Functional Determinants of Metal Ion Transport and Selectivity in Paralogous Cation Diffusion Facilitator Transporters CzcD and MntE in Streptococcus pneumoniae

(2016) Julia E. Martin et al.   JOURNAL OF BACTERIOLOGY

Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter

(2016) Yukina Nishito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effects of type 2 diabetes on brain glycometabolism in rats: focus on glycogen and monocarboxylate transporter 2

(2016) Takeru Shima et al.   Journal of Physiological Sciences

Inhibition of monocarboxylate transporter 1 suppresses the proliferation of glioblastoma stem cells

(2016) Tetsuya Takada et al.   Journal of Physiological Sciences

Sodium ion transport participates in non-neuronal acetylcholine release in the renal cortex of anesthetized rabbits

(2016) Shuji Shimizu et al.   Journal of Physiological Sciences

Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal–fetal calcium transport

(2016) Yoshiro Suzuki et al.   Journal of Physiological Sciences

Transient receptor potential cation 3 channel regulates melanoma proliferation and migration

(2016) Kayoko Oda et al.   Journal of Physiological Sciences

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Novel mutations in SLC30A2 involved in the pathogenesis of transient neonatal zinc deficiency

(2016) Naoya Itsumura et al.   PEDIATRIC RESEARCH

Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity

(2016) Yitong Zhao et al.   TRAFFIC

Structural insights of ZIP4 extracellular domain critical for optimal zinc transport

(2016) Tuo Zhang et al.   Nature Communications

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia

(2016) Karin Tuschl et al.   Nature Communications

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

(2016) Wakana Ohashi et al.   PLoS Genetics

SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation

(2015) Julien H. Park et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8

(2015) Kym M. Boycott et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting

(2015) A. Hashimoto et al.   BIOCHEMICAL JOURNAL

SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

(2015) Supak Jenkitkasemwong et al.   Cell Metabolism

A high molecular mass zinc transporter MTP12 forms a functional heteromeric complex with MTP5 in the Golgi inArabidopsis thaliana

(2015) Takashi Fujiwara et al.   FEBS Journal

Cation Diffusion Facilitator family: Structure and function

(2015) Olga Kolaj-Robin et al.   FEBS LETTERS

Essential Role for Zinc Transporter 2 (ZnT2)-mediated Zinc Transport in Mammary Gland Development and Function during Lactation

(2015) Sooyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computation and Functional Studies Provide a Model for the Structure of the Zinc Transporter hZIP4

(2015) Sagar Antala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterodimerization, Altered Subcellular Localization, and Function of Multiple Zinc Transporters in Viable Cells Using Bimolecular Fluorescence Complementation

(2015) Yarden Golan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes

(2015) Sevil Korkmaz-Icöz et al.   Journal of Physiological Sciences

Regulation of intracellular Zn homeostasis in two intestinal epithelial cell models at various maturation time points

(2015) Eva-Maria Gefeller et al.   Journal of Physiological Sciences

KATP channels and MPTP are involved in the cardioprotection bestowed by chronic intermittent hypobaric hypoxia in the developing rat

(2015) Hui-min Bu et al.   Journal of Physiological Sciences

Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8

(2015) Masayuki Takaishi et al.   Journal of Physiological Sciences

The Zinc Finger Protein ZNF658 Regulates the Transcription of Genes Involved in Zinc Homeostasis and Affects Ribosome Biogenesis through the Zinc Transcriptional Regulatory Element

(2015) Ogo A. Ogo et al.   MOLECULAR AND CELLULAR BIOLOGY

The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia

(2015) Lan Zhao et al.   NATURE

The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism

(2015) Taiho Kambe et al.   PHYSIOLOGICAL REVIEWS

Loss of synaptic Zn2+ transporter function increases risk of febrile seizures

(2015) Michael S. Hildebrand et al.   Scientific Reports

Mitochondrial and ER-Targeted eCALWY Probes Reveal High Levels of Free Zn2+

(2014) Pauline Chabosseau et al.   ACS Chemical Biology

Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis

(2014) Jin-Hong Kim et al.   CELL

Current understanding of ZIP and ZnT zinc transporters in human health and diseases

(2014) Taiho Kambe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular pathogenesis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins

(2014) B.-H. Bin et al.   EMBO Molecular Medicine

Identification and Characterization of Membrane Androgen Receptors in the ZIP9 Zinc Transporter Subfamily: II. Role of Human ZIP9 in Testosterone-Induced Prostate and Breast Cancer Cell Apoptosis

(2014) Peter Thomas et al.   ENDOCRINOLOGY

Association between ZIP10 gene expression and tumor aggressiveness in renal cell carcinoma

(2014) Deeksha Pal et al.   GENE

Zinc Signals Are Essential for Lipopolysaccharide-Induced Signal Transduction in Monocytes

(2014) H. Haase et al.   JOURNAL OF IMMUNOLOGY

SLC39A5mutations interfering with the BMP/TGF-β pathway in non-syndromic high myopia

(2014) Hui Guo et al.   JOURNAL OF MEDICAL GENETICS

Potential role of transient receptor potential (TRP) channels in bladder cancer cells

(2014) Hideki Mizuno et al.   Journal of Physiological Sciences

ZnT-1 extrudes zinc from mammalian cells functioning as a Zn2+/H+ exchanger

(2014) Eden Shusterman et al.   Metallomics

Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition

(2014) B.Y. Kong et al.   MOLECULAR HUMAN REPRODUCTION

Visualizing the kinetic power stroke that drives proton-coupled zinc(ii) transport

(2014) Sayan Gupta et al.   NATURE

Cation Diffusion Facilitators Transport Initiation and Regulation Is Mediated by Cation Induced Conformational Changes of the Cytoplasmic Domain

(2014) Natalie Zeytuni et al.   PLoS One

Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength

(2014) S. Hojyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development

(2014) T. Miyai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparing Gene Expression during Cadmium Uptake and Distribution: Untreated versus Oral Cd-Treated Wild-Type and ZIP14 Knockout Mice

(2014) Lucia F. Jorge-Nebert et al.   TOXICOLOGICAL SCIENCES

Direct Comparison of a Genetically Encoded Sensor and Small Molecule Indicator: Implications for Quantification of Cytosolic Zn2+

(2013) Yan Qin et al.   ACS Chemical Biology

Update on Zinc Deficiency and Excess in Clinical Pediatric Practice

(2013) Nancy F. Krebs   ANNALS OF NUTRITION AND METABOLISM

Allosteric modulation of zinc speciation by fatty acids

(2013) James P. Barnett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup

(2013) C. Groth et al.   DEVELOPMENT

A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth

(2013) Yuqing Zhang et al.   EMBO Molecular Medicine

ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders

(2013) H. Nam et al.   HAEMATOLOGICA

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

(2013) Motoyuki Tamaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Compound Heterozygous Mutations in SLC30A2/ZnT2 Results in Low Milk Zinc Concentrations: A Novel Mechanism for Zinc Deficiency in a Breast-Fed Infant

(2013) Naoya Itsumura et al.   PLoS One

ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB

(2013) Ming-Jie Liu et al.   Cell Reports

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

(2013) Jarom Heijmans et al.   Cell Reports

Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver Disease

(2012) Marialuisa Quadri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Human ZIP4 Transporter Has Two Distinct Binding Affinities and Mediates Transport of Multiple Transition Metals

(2012) Sagar Antala et al.   BIOCHEMISTRY

The Zinc Transporter Zip14 Influences c-Met Phosphorylation and Hepatocyte Proliferation During Liver Regeneration in Mice

(2012) Tolunay Beker Aydemir et al.   GASTROENTEROLOGY

Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion

(2012) Bryan J. McCranor et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Znt7-null Mice Are More Susceptible to Diet-induced Glucose Intolerance and Insulin Resistance

(2012) Liping Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc signal: a new player in osteobiology

(2012) Toshiyuki Fukada et al.   JOURNAL OF BONE AND MINERAL METABOLISM

LIV-1 ZIP Ectodomain Shedding in Prion-Infected Mice Resembles Cellular Response to Transition Metal Starvation

(2012) Sepehr Ehsani et al.   JOURNAL OF MOLECULAR BIOLOGY

Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis

(2012) Helen J. Bosomworth et al.   Metallomics

Dystonia with brain manganese accumulation resulting fromSLC30A10mutations: A new treatable disorder

(2012) Maria Stamelou et al.   MOVEMENT DISORDERS

ZIP8 Zinc Transporter: Indispensable Role for Both Multiple-Organ Organogenesis and Hematopoiesis In Utero

(2012) Marina Gálvez-Peralta et al.   PLoS One

Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity

(2012) E. Hoch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc Sparks Are Triggered by Fertilization and Facilitate Cell Cycle Resumption in Mammalian Eggs

(2011) Alison M. Kim et al.   ACS Chemical Biology

Regulation of zinc-responsive Slc39a5 (Zip5) translation is mediated by conserved elements in the 3′-untranslated region

(2011) Benjamin P. Weaver et al.   BIOMETALS

Metals on the move: zinc ions in cellular regulation and in the coordination dynamics of zinc proteins

(2011) Wolfgang Maret   BIOMETALS

An Overview of a Wide Range of Functions of ZnT and Zip Zinc Transporters in the Secretory Pathway

(2011) Taiho KAMBE   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Structure and evolution of the plant cation diffusion facilitator family of ion transporters

(2011) Jeffery L Gustin et al.   BMC EVOLUTIONARY BIOLOGY

Tissue Nonspecific Alkaline Phosphatase Is Activated via a Two-step Mechanism by Zinc Transport Complexes in the Early Secretory Pathway

(2011) Ayako Fukunaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Characterization of Human ZIP13 Protein

(2011) Bum-Ho Bin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc homeostasis and signaling in health and diseases

(2011) Toshiyuki Fukada et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A bioinformatics view of zinc enzymes

(2011) Claudia Andreini et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Putative role of intracellular Zn2+ release during oxidative stress: a trigger to restore cellular thiol content that is decreased by oxidative stress

(2011) Akio Kinazaki et al.   Journal of Physiological Sciences

Molecular and genetic features of zinc transporters in physiology and pathogenesis

(2011) Toshiyuki Fukada et al.   Metallomics

The Zinc Transporter SLC39A14/ZIP14 Controls G-Protein Coupled Receptor-Mediated Signaling Required for Systemic Growth

(2011) Shintaro Hojyo et al.   PLoS One

Measuring steady-state and dynamic endoplasmic reticulum and Golgi Zn2+ with genetically encoded sensors

(2011) Y. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

Zinc suppresses Th17 development via inhibition of STAT3 activation

(2010) Chika Kitabayashi et al.   INTERNATIONAL IMMUNOLOGY

Selective Electrodiffusion of Zinc Ions in a Zrt-, Irt-like Protein, ZIPB

(2010) Wei Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

Cytosolic metal handling in plants: determinants for zinc specificity in metal transporters and metallothioneins

(2010) Claudia A. Blindauer et al.   Metallomics

STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells

(2010) L. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Family reunion – The ZIP/prion gene family

(2010) Sepehr Ehsani et al.   PROGRESS IN NEUROBIOLOGY

Metalloproteomes: A Bioinformatic Approach

(2009) Claudia Andreini et al.   ACCOUNTS OF CHEMICAL RESEARCH

Genetic Control of Bone Formation

(2009) Gerard Karsenty et al.   Annual Review of Cell and Developmental Biology

Mammalian Zinc Transporters: Nutritional and Physiologic Regulation

(2009) Louis A. Lichten et al.   Annual Review of Nutrition

PTH and PTHrP signaling in osteoblasts

(2009) Nabanita S. Datta et al.   CELLULAR SIGNALLING

Coordination Dynamics of Zinc in Proteins

(2009) Wolfgang Maret et al.   CHEMICAL REVIEWS

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice

(2009) Fang Zhao et al.   DEVELOPMENTAL BIOLOGY

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

Identification of the Zn2+Binding Site and Mode of Operation of a Mammalian Zn2+Transporter

(2009) Ehud Ohana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration and Characterization of the Heterodimerization of ZnT5 and ZnT6 in the Early Secretory Pathway

(2009) Ayako Fukunaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc transporter Znt5/Slc30a5 is required for the mast cell–mediated delayed-type allergic reaction but not the immediate-type reaction

(2009) Keigo Nishida et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

(2009) Jan L Vinkenborg et al.   NATURE METHODS

Zinc in the physiology and pathology of the CNS

(2009) Stefano L. Sensi et al.   NATURE REVIEWS NEUROSCIENCE

Structural basis for autoregulation of the zinc transporter YiiP

(2009) Min Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SLC30A3 (ZnT3) Oligomerization by Dityrosine Bonds Regulates Its Subcellular Localization and Metal Transport Capacity

(2009) Gloria Salazar et al.   PLoS One

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the cytosolic domain of the cation diffusion facilitator family protein

(2009) Takashi Higuchi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Spondylocheiro Dysplastic Form of the Ehlers-Danlos Syndrome—An Autosomal-Recessive Entity Caused by Mutations in the Zinc Transporter Gene SLC39A13

(2008) Cecilia Giunta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Insights into Zn2+ homeostasis in neurons from experimental and modeling studies

(2008) Robert A. Colvin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency

(2008) Taiho Kambe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Regulation and function ofZip4, the acrodermatitis enteropathica gene

(2008) Glen K. Andrews   BIOCHEMICAL SOCIETY TRANSACTIONS

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

The genetics of essential metal homeostasis during development

(2008) Taiho Kambe et al.   GENESIS

Deletion of a Histidine-rich Loop of AtMTP1, a Vacuolar Zn2+/H+Antiporter ofArabidopsis thaliana, Stimulates the Transport Activity

(2008) Miki Kawachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc Transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in Mouse Red Blood Cells Are Differentially Regulated during Erythroid Development and by Dietary Zinc Deficiency

(2008) Moon-Suhn Ryu et al.   JOURNAL OF NUTRITION

Novel Proteolytic Processing of the Ectodomain of the Zinc Transporter ZIP4 (SLC39A4) during Zinc Deficiency Is Inhibited by Acrodermatitis Enteropathica Mutations

(2008) T. Kambe et al.   MOLECULAR AND CELLULAR BIOLOGY

The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways

(2008) Toshiyuki Fukada et al.   PLoS One

Insights into the Mode of Action of a Putative Zinc Transporter CzrB in Thermus thermophilus

(2008) Vadim Cherezov et al.   STRUCTURE

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE