Aging and Intermittent Fasting Impact on Transcriptional Regulation and Physiological Responses of Adult Drosophila Neuronal and Muscle Tissues

The mitochondrial ATP synthase is a shared drug target for aging and dementia

(2018) Joshua Goldberg et al.   AGING CELL

Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

(2017) Antonio Currais et al.   FASEB JOURNAL

Shaping proteostasis at the cellular, tissue, and organismal level

(2017) Ambre J. Sala et al.   JOURNAL OF CELL BIOLOGY

Transcriptional Signatures of Aging

(2017) R. Stegeman et al.   JOURNAL OF MOLECULAR BIOLOGY

Time-restricted feeding for prevention and treatment of cardiometabolic disorders

(2017) Girish C. Melkani et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabolic drift in the aging brain

(2016) Julijana Ivanisevic et al.   Aging-US

Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila

(2016) Brian Xia et al.   Aging-US

Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins

(2016) Sarah Hanzén et al.   CELL

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

Energetic interventions for healthspan and resiliency with aging

(2016) Derek M. Huffman et al.   EXPERIMENTAL GERONTOLOGY

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span inDrosophila

(2016) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Does Longer Lifespan Mean Longer Healthspan?

(2016) Malene Hansen et al.   TRENDS IN CELL BIOLOGY

Using Drosophila as an integrated model to study mild repetitive traumatic brain injury

(2016) Ayeh Barekat et al.   Scientific Reports

Epigenetics and aging

(2016) S. Pal et al.   Science Advances

Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging

(2016) Nan Jiang et al.   Aging-US

Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles

(2016) Eric P. Ratliff et al.   PLoS One

Lifelong brain health is a lifelong challenge: From evolutionary principles to empirical evidence

(2015) Mark P. Mattson   AGEING RESEARCH REVIEWS

Atypical antidepressants extend lifespan ofCaenorhabditis elegansby activation of a non-cell-autonomous stress response

(2015) Sunitha Rangaraju et al.   AGING CELL

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila

(2015) Gary N. Landis et al.   Aging-US

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

(2015) Antonio Currais et al.   Aging-US

Mitochondrial maintenance failure in aging and role of sexual dimorphism

(2015) John Tower   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Epigenetics of Aging

(2015) Marta Sierra et al.   CURRENT GENOMICS

Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors

(2015) Eric P. Ratliff et al.   PLoS One

Time-restricted feeding attenuates age-related cardiac decline in Drosophila

(2015) S. Gill et al.   SCIENCE

Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality

(2015) Sunitha Rangaraju et al.   eLife

Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process

(2015) Geneviève Morrow et al.   Frontiers in Genetics

Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures

(2015) Marissa J. Schafer et al.   PLoS One

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Intermittent fasting attenuates inflammasome activity in ischemic stroke

(2014) David Yang-Wei Fann et al.   EXPERIMENTAL NEUROLOGY

Exercise, Energy Intake, Glucose Homeostasis, and the Brain

(2014) H. van Praag et al.   JOURNAL OF NEUROSCIENCE

Control of metabolic adaptation to fasting by dILP6-induced insulin signaling inDrosophilaoenocytes

(2014) Debamita Chatterjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap

(2014) Tytus Murphy et al.   NEURAL PLASTICITY

Proteasome dysfunction inDrosophilasignals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

(2013) Eleni N. Tsakiri et al.   AGING CELL

Promoting longevity by maintaining metabolic and proliferative homeostasis

(2013) L. Wang et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Variegated Expression of Hsp22 Transgenic Reporters Indicates Cell-specific Patterns of Aging in Drosophila Oenocytes

(2013) John Tower et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Count-based differential expression analysis of RNA sequencing data using R and Bioconductor

(2013) Simon Anders et al.   Nature Protocols

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy

(2013) Jonathan Zirin et al.   PLOS BIOLOGY

Identification of Sphingolipid Metabolites That Induce Obesity via Misregulation of Appetite, Caloric Intake and Fat Storage in Drosophila

(2013) Stanley M. Walls et al.   PLoS Genetics

Dietary restriction supports peripheral nerve health by enhancing endogenous protein quality control mechanisms

(2012) Sooyeon Lee et al.   EXPERIMENTAL GERONTOLOGY

Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan

(2011) Rochele Yamamoto et al.   AGING CELL

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

(2011) Bryan J. Bartlett et al.   Autophagy

Whole-transcriptome RNAseq analysis from minute amount of total RNA

(2011) Muhammad A. Tariq et al.   NUCLEIC ACIDS RESEARCH

Chromatin remodeling in the aging genome of Drosophila

(2010) Jason G. Wood et al.   AGING CELL

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of a Standardised Dietary Restriction Protocol on Multiple Laboratory Strains of Drosophila melanogaster

(2009) Richard C. Grandison et al.   PLoS One

Drosophila lifespan control by dietary restriction independent of insulin-like signaling

(2008) Kyung-Jin Min et al.   AGING CELL

Opposing Effects of Dietary Protein and Sugar Regulate a Transcriptional Target of Drosophila Insulin-like Peptide Signaling

(2008) Susanne Buch et al.   Cell Metabolism

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

(2008) Björn Schumacher et al.   PLoS Genetics