Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

Ageing and inflammation – A central role for mitochondria in brain health and disease

(2015) Antonio Currais   AGEING RESEARCH REVIEWS

Asymmetric damage segregation at cell division via protein aggregate fusion and attachment to organelles

(2015) Miguel Coelho et al.   BIOESSAYS

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

(2015) Alaina Baker-Nigh et al.   BRAIN

Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease

(2015) I A Clark et al.   BRITISH JOURNAL OF PHARMACOLOGY

Surviving protein quality control catastrophes - from cells to organisms

(2015) K. Schneider et al.   JOURNAL OF CELL SCIENCE

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

Endocannabinoid signalling and the deteriorating brain

(2015) Vincenzo Di Marzo et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial DNA in the regulation of innate immune responses

(2015) Chunju Fang et al.   Protein & Cell

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

(2015) Marta Carrara et al.   eLife

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Inflammation, ageing and chronic disease

(2014) Graham Pawelec et al.   CURRENT OPINION IN IMMUNOLOGY

The mystery of aging and rejuvenation—a budding topic

(2014) Thomas Nyström et al.   CURRENT OPINION IN MICROBIOLOGY

Stress, Inflammation, and Defense of Homeostasis

(2014) Raj Chovatiya et al.   MOLECULAR CELL

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease

(2014) Cecilia E. Hanzel et al.   NEUROBIOLOGY OF AGING

Phospholipase A2 – nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment

(2014) Petra M. Hermann et al.   Frontiers in Genetics

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures

(2013) Brandon H. Toyama et al.   CELL

Modulation of 5-Lipoxygenase in Proteotoxicity and Alzheimer's Disease

(2013) E. Valera et al.   JOURNAL OF NEUROSCIENCE

Learning and memory ... and the immune system

(2013) I. Marin et al.   LEARNING & MEMORY

Mitochondrial dysfunction and the inflammatory response

(2013) María J. López-Armada et al.   MITOCHONDRION

The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan

(2013) Vadim N. Gladyshev   TRENDS IN GENETICS

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Rational heterodoxy: Cholesterol reformation of the amyloid doctrine

(2012) Michael A. Castello et al.   AGEING RESEARCH REVIEWS

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Unfolded protein response

(2012) Stewart Siyan Cao et al.   CURRENT BIOLOGY

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

Role of Cytosolic Calcium-Dependent Phospholipase A2 in Alzheimer's Disease Pathogenesis

(2012) M. T. Gentile et al.   MOLECULAR NEUROBIOLOGY

Protein homeostasis: live long, won't prosper

(2012) Brandon H. Toyama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Temporal Dynamics of Bacterial Aging and Rejuvenation

(2011) Camilla U. Rang et al.   CURRENT BIOLOGY

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Cellular Strategies of Protein Quality Control

(2011) B. Chen et al.   Cold Spring Harbor Perspectives in Biology

Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation

(2010) Eri Himeno et al.   ANNALS OF NEUROLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Inflammation and Alzheimer’s disease

(2010) Young-Jung Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Active Immunization with Amyloid-  1-42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

(2010) P. Vollmar et al.   JOURNAL OF IMMUNOLOGY

Effects of Synaptic Modulation on  -Amyloid, Synaptophysin, and Memory Performance in Alzheimer's Disease Transgenic Mice

(2010) D. Tampellini et al.   JOURNAL OF NEUROSCIENCE

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identifying the amylome, proteins capable of forming amyloid-like fibrils

(2010) Lukasz Goldschmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Replicative Aging in Yeast: The Means to the End

(2008) K.A. Steinkraus et al.   Annual Review of Cell and Developmental Biology

Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart

(2008) Feng Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

(2008) A. Tonoki et al.   MOLECULAR AND CELLULAR BIOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Biomarkers of Alzheimer's disease

(2008) Rebecca Craig-Schapiro et al.   NEUROBIOLOGY OF DISEASE