Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis

4′,6-Dimethoxyisoflavone-7-O-β-d-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor α (PPARα) agonist in mouse hepatocytes

(2018) Misato Suzuki et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Distinct but complementary contributions of PPAR isotypes to energy homeostasis

(2017) Vanessa Dubois et al.   JOURNAL OF CLINICAL INVESTIGATION

Central leptin regulates heart lipid content by selectively increasing PPAR β/δ expression

(2017) Cristina Mora et al.   JOURNAL OF ENDOCRINOLOGY

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice

(2017) Kenta Takei et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The Interplay between Metabolism, PPAR Signaling Pathway, and Cancer

(2017) Daniele Fanale et al.   PPAR Research

Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway

(2017) Laura La Paglia et al.   PPAR Research

Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells

(2017) Aneta A. Koronowicz et al.   PPAR Research

PPAR Agonists for the Prevention and Treatment of Lung Cancer

(2017) Sowmya P. Lakshmi et al.   PPAR Research

Deciphering the Roles of Thiazolidinediones and PPARγ in Bladder Cancer

(2017) Melody Chiu et al.   PPAR Research

Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism

(2017) Muthu Periasamy et al.   Diabetes & Metabolism Journal

Leucine stimulates PPARβ/δ-dependent mitochondrial biogenesis and oxidative metabolism with enhanced GLUT4 content and glucose uptake in myotubes

(2016) Jamie K. Schnuck et al.   BIOCHIMIE

Syringaresinol induces mitochondrial biogenesis through activation of PPARβ pathway in skeletal muscle cells

(2016) Trung Thanh Thach et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Roles of PPAR transcription factors in the energetic metabolic switch occurring during adult neurogenesis

(2016) E. Di Giacomo et al.   CELL CYCLE

The Relationship Between KLF5 and PPARα in the Heart

(2016) Nathan D. Roe et al.   CIRCULATION RESEARCH

Targeting fatty acid metabolism in heart failure: is it a suitable therapeutic approach?

(2016) Somasundaram Arumugam et al.   DRUG DISCOVERY TODAY

Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development

(2016) Madeliene Stump et al.   ENDOCRINOLOGY

The effect of diet interventions on hypothalamic nutrient sensing pathways in rodents

(2016) Merel Rijnsburger et al.   PHYSIOLOGY & BEHAVIOR

PPARs and Mitochondrial Metabolism: From NAFLD to HCC

(2016) Tommaso Mello et al.   PPAR Research

PPARδas a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance

(2016) Robert I. Glazer   PPAR Research

Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis

(2016) Borja Bandera Merchan et al.   PPAR Research

Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions

(2016) Salvatore Giovanni Vitale et al.   PPAR Research

Increased glucose utilization and decreased fatty acid metabolism in myotubes fromGlmpgt/gtmice

(2016) Xiang Yi Kong et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac FunctionNovelty and Significance

(2015) Konstantinos Drosatos et al.   CIRCULATION RESEARCH

PPARs and ERRs: molecular mediators of mitochondrial metabolism

(2015) Weiwei Fan et al.   CURRENT OPINION IN CELL BIOLOGY

Propionate Promotes Fatty Acid Oxidation through the Up-Regulation of Peroxisome Proliferator-Activated Receptor α in Intestinal Epithelial Cells

(2015) Yasuki HIGASHIMURA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Exploring the emerging complexity in transcriptional regulation of energy homeostasis

(2015) Adelheid Lempradl et al.   NATURE REVIEWS GENETICS

Peroxisome proliferator-activated receptorβ/δ activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation

(2015) L Li et al.   Cell Death & Disease

The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet

(2014) Joaquín Pérez-Schindler et al.   DIABETOLOGIA

ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways

(2013) Agata Korecka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1)- and Estrogen-related Receptor (ERR)-induced Regulator in Muscle 1 (PERM1) Is a Tissue-specific Regulator of Oxidative Capacity in Skeletal Muscle Cells

(2013) Yoshitake Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comparative perspective on lipid storage in animals

(2013) K. Birsoy et al.   JOURNAL OF CELL SCIENCE

The orphan nuclear receptors at their 25-year reunion

(2013) Shannon E Mullican et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Possible Role of Intestinal Fatty Acid Oxidation in the Eating-Inhibitory Effect of the PPAR-α Agonist Wy-14643 in High-Fat Diet Fed Rats

(2013) Elnaz Karimian Azari et al.   PLoS One

PPARs and Liver Disease

(2013) Yasuteru Kondo et al.   PPAR Research

An Ethanol Extract of Artemisia iwayomogi Activates PPARδ Leading to Activation of Fatty Acid Oxidation in Skeletal Muscle

(2012) Si Young Cho et al.   PLoS One

Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity

(2012) Heidi E. Kocalis et al.   PLoS One

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

(2011) Hiroyasu Yamamoto et al.   CELL

PPARγ as a therapeutic target in diabetic nephropathy and other renal diseases

(2011) Jichun Yang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion

(2011) Guy Cohen et al.   DIABETES

The nuclear receptor PPAR /  programs muscle glucose metabolism in cooperation with AMPK and MEF2

(2011) Z. Gan et al.   GENES & DEVELOPMENT

G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart

(2011) Jinjiang Pang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Brain PPAR-γ promotes obesity and is required for the insulin–sensitizing effect of thiazolidinediones

(2011) Min Lu et al.   NATURE MEDICINE

A role for central nervous system PPAR-γ in the regulation of energy balance

(2011) Karen K Ryan et al.   NATURE MEDICINE

Fasting Induces the Expression of PGC-1α and ERR Isoforms in the Outer Stripe of the Outer Medulla (OSOM) of the Mouse Kidney

(2011) Christina T. Teng et al.   PLoS One

PPARs: diverse regulators in energy metabolism and metabolic diseases

(2010) Yong-Xu Wang   CELL RESEARCH

Activation of PPARδ promotes mitochondrial energy metabolism and decreases basal insulin secretion in palmitate-treated β-cells

(2010) Li Jiang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Activation of PPARδ up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic β-cells

(2009) Jun Wan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peroxisome proliferator-activated receptors and renal diseases

(2009) Jing Wu   Frontiers in Bioscience-Landmark

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux

(2009) Carlos L. J. Vrins et al.   JOURNAL OF LIPID RESEARCH

Potential utility of PPARα activation in the prevention of ischemic and drug-induced acute renal damage

(2009) Francisco J. Lopez-Hernandez et al.   KIDNEY INTERNATIONAL

Transgenic expression of proximal tubule peroxisome proliferator–activated receptor-α in mice confers protection during acute kidney injury

(2009) Shenyang Li et al.   KIDNEY INTERNATIONAL

Hepatocyte Nuclear Factor 4  Coordinates a Transcription Factor Network Regulating Hepatic Fatty Acid Metabolism

(2009) C. P. Martinez-Jimenez et al.   MOLECULAR AND CELLULAR BIOLOGY

Peroxisome proliferator-activated receptor-γ (PPARγ) modulates hypothalamic Trh regulation in vivo

(2009) Soumaya Kouidhi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression

(2008) Heleen M de Vogel-van den Bosch et al.   BMC GENOMICS

Expression of Peroxisome Proliferator-Activated Receptor-γ in Key Neuronal Subsets Regulating Glucose Metabolism and Energy Homeostasis

(2008) David A. Sarruf et al.   ENDOCRINOLOGY

LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney

(2008) Kenneth R. Feingold et al.   JOURNAL OF LIPID RESEARCH

Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplatin-induced acute kidney injury

(2008) K. Negishi et al.   KIDNEY INTERNATIONAL

The Role of PPARs in Cancer

(2008) Keisuke Tachibana et al.   PPAR Research

Mitochondria, PPARs, and Cancer: Is Receptor-Independent Action of PPAR Agonists a Key?

(2008) Roberto Scatena et al.   PPAR Research