PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders

Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms

(2018) Amir Tajbakhsh et al.   PHARMACOLOGY & THERAPEUTICS

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease

(2018) Mohammad Zarei et al.   Molecular Metabolism

Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia

(2017) Marcela Doktorova et al.   Scientific Reports

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

(2016) Joel T. Haas et al.   Annual Review of Physiology

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ

(2016) Nguan Soon Tan et al.   PROGRESS IN LIPID RESEARCH

Unraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease

(2016) Manuel Vázquez-Carrera   TRENDS IN ENDOCRINOLOGY AND METABOLISM

New insights into the pathophysiology of dyslipidemia in type 2 diabetes

(2015) Marja-Riitta Taskinen et al.   ATHEROSCLEROSIS

PPAR-β/δ activation promotes phospholipid transfer protein expression

(2015) Khouloud Chehaibi et al.   BIOCHEMICAL PHARMACOLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Establishing the Role of PPARβ/δ in Carcinogenesis

(2015) Jeffrey M. Peters et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin resistance and impaired adipogenesis

(2015) Birgit Gustafson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PPARαIs Required for PPARδAction in Regulation of Body Weight and Hepatic Steatosis in Mice

(2015) Wojciech G. Garbacz et al.   PPAR Research

IL-6 in diabetes and cardiovascular complications

(2014) Dan Qu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism

(2014) Laia Salvadó et al.   DIABETOLOGIA

PPARδ activation attenuates hepatic steatosis inLdlr−/−mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

(2014) Lazar A. Bojic et al.   JOURNAL OF LIPID RESEARCH

Targeting the pancreatic β-cell to treat diabetes

(2014) Amedeo Vetere et al.   NATURE REVIEWS DRUG DISCOVERY

Physiological Functions of Peroxisome Proliferator-Activated Receptor β

(2014) Jaap G. Neels et al.   PHYSIOLOGICAL REVIEWS

Peroxisome proliferator-activated receptor delta and cardiovascular disease

(2013) Ewa Ehrenborg et al.   ATHEROSCLEROSIS

Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells

(2013) Tianyi Tang et al.   Cell Metabolism

Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor

(2013) Yan Yang et al.   CELLULAR SIGNALLING

PPARδ binding to heme oxygenase 1 promoter prevents angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive rats

(2013) K Sodhi et al.   INTERNATIONAL JOURNAL OF OBESITY

A comparative perspective on lipid storage in animals

(2013) K. Birsoy et al.   JOURNAL OF CELL SCIENCE

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications

(2013) Norbert Stefan et al.   Lancet Diabetes & Endocrinology

Activation of Peroxisome Proliferator-Activated Receptor δ Inhibits Human Macrophage Foam Cell Formation and the Inflammatory Response Induced by Very Low-Density Lipoprotein

(2012) Lazar A. Bojic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipid Effects of Peroxisome Proliferator-Activated Receptor-Δ Agonist GW501516 in Subjects With Low High-Density Lipoprotein Cholesterol

(2012) Eric J. Olson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism

(2012) Mi Young Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Protection from liver fibrosis by a peroxisome proliferator-activated receptor   agonist

(2012) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

(2012) Radina Kostadinova et al.   Cell and Bioscience

Effects of the PPAR-δ agonist MBX-8025 on atherogenic dyslipidemia

(2011) Yun-Jung Choi et al.   ATHEROSCLEROSIS

Peroxisome proliferator-activated receptors and cancer: challenges and opportunities

(2011) Jihan Youssef et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of Peroxisome Proliferator-Activated Receptor- /-  (PPAR- /- ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6-Stimulated Adipocytes

(2011) L. Serrano-Marco et al.   DIABETES

The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells

(2011) L. Serrano-Marco et al.   DIABETOLOGIA

The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation

(2011) Emma Barroso et al.   ENDOCRINOLOGY

PPARβ/δ Activation Induces Enteroendocrine L Cell GLP-1 Production

(2011) Mehdi Daoudi et al.   GASTROENTEROLOGY

The nuclear receptor PPAR /  programs muscle glucose metabolism in cooperation with AMPK and MEF2

(2011) Z. Gan et al.   GENES & DEVELOPMENT

Pharmacological Activation of Peroxisome Proliferator-activated Receptor δ Improves Insulin Resistance and Hepatic Steatosis in High Fat Diet-induced Diabetic Mice

(2011) H.-T. Wu et al.   HORMONE AND METABOLIC RESEARCH

MBX-8025, A Novel Peroxisome Proliferator Receptor-δ Agonist: Lipid and Other Metabolic Effects in Dyslipidemic Overweight Patients Treated with and without Atorvastatin

(2011) Harold E. Bays et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The global obesity pandemic: shaped by global drivers and local environments

(2011) Boyd A Swinburn et al.   LANCET

Modulation of Macrophage Efferocytosis in Inflammation

(2011) Darlynn Korns et al.   Frontiers in Immunology

Activation of Peroxisome Proliferator-Activated Receptor-δ by GW501516 Prevents Fatty Acid-Induced Nuclear Factor-κB Activation and Insulin Resistance in Skeletal Muscle Cells

(2010) Teresa Coll et al.   ENDOCRINOLOGY

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

(2010) Sihao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

PPARδ Agonism Activates Fatty Acid Oxidation via PGC-1α but Does Not Increase Mitochondrial Gene Expression and Function

(2009) Sandra Kleiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man

(2009) Constantinos Christodoulides et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

(2009) Kim Ravnskjaer et al.   JOURNAL OF LIPID RESEARCH

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux

(2009) Carlos L. J. Vrins et al.   JOURNAL OF LIPID RESEARCH

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

Emerging roles of peroxisome proliferator-activated receptor-β/δ in inflammation

(2009) David Bishop-Bailey et al.   PHARMACOLOGY & THERAPEUTICS

Transcriptional profiling reveals divergent roles of PPARα and PPARβ/δ in regulation of gene expression in mouse liver

(2009) Linda M. Sanderson et al.   PHYSIOLOGICAL GENOMICS

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Activation of Peroxisome Proliferator-Activated Receptor  /  Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor- B Activity via Extracellular Signal-Related Kinase 1/2

(2008) R. Rodriguez-Calvo et al.   DIABETES

PPAR-β/δ agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home

(2008) Andrew N Billin   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Peroxisome proliferator-activated receptor-δ induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice

(2008) Xiaomei Qin et al.   HEPATOLOGY

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Ligand Activation of Peroxisome Proliferator-Activated Receptor- /  Inhibits Cell Proliferation in Human HaCaT Keratinocytes

(2008) M. G. Borland et al.   MOLECULAR PHARMACOLOGY

Ligand-Mediated Regulation of Peroxisome Proliferator-Activated Receptor (PPAR)  / : A Comparative Analysis of PPAR-Selective Agonists and All-trans Retinoic Acid

(2008) M. Rieck et al.   MOLECULAR PHARMACOLOGY

It's Not How Fat You Are, It's What You Do with It That Counts

(2008) Samuel Virtue et al.   PLOS BIOLOGY