From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation

The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats

(2016) Tito Borner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity

(2016) Jong Han Lee et al.   DIABETES

Des-Acyl Ghrelin and Ghrelin O-Acyltransferase Regulate Hypothalamic-Pituitary-Adrenal Axis Activation and Anxiety in Response to Acute Stress

(2016) Romana Stark et al.   ENDOCRINOLOGY

Relamorelin Reduces Vomiting Frequency and Severity and Accelerates Gastric Emptying in Adults With Diabetic Gastroparesis

(2016) Anthony Lembo et al.   GASTROENTEROLOGY

Acylated but not des-acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease

(2016) Jacqueline A. Bayliss et al.   JOURNAL OF NEUROCHEMISTRY

Homeostasis Meets Motivation in the Battle to Control Food Intake

(2016) Carrie R. Ferrario et al.   JOURNAL OF NEUROSCIENCE

Lateral hypothalamic circuits for feeding and reward

(2016) Garret D Stuber et al.   NATURE NEUROSCIENCE

Two ghrelin receptor agonists for adults with malnutrition: a systematic review and meta-analysis

(2016) Jianhua Su et al.   Nutrition Journal

The suppression of ghrelin signaling mitigates age-associated thermogenic impairment

(2016) Ligen Lin et al.   Aging-US

The ghrelin receptor agonist, HM01, activates the innervation of the colon to initiate coordinated propulsive contractions and bowel emptying

(2015) K. Naitou et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Orally active ghrelin receptor inverse agonists and their actions on a rat obesity model

(2015) Bitoku Takahashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor

(2015) Andras Kern et al.   CELL

Decoding Neural Circuits that Control Compulsive Sucrose Seeking

(2015) Edward H. Nieh et al.   CELL

Acyl Ghrelin Acts in the Brain to Control Liver Function and Peripheral Glucose Homeostasis in Male Mice

(2015) Romana Stark et al.   ENDOCRINOLOGY

New targets to treat obesity and the metabolic syndrome

(2015) Kathleen A. Martin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A ghrelin receptor (GHS-R1A) antagonist attenuates the rewarding properties of morphine and increases opioid peptide levels in reward areas in mice

(2015) Jörgen A. Engel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC

(2015) Hongjie Zhang et al.   EXPERT OPINION ON PHARMACOTHERAPY

Ghrelin Receptor Ligands Reaching Clinical Trials: From Peptides to Peptidomimetics; from Agonists to Antagonists

(2015) M. Vodnik et al.   HORMONE AND METABOLIC RESEARCH

Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin

(2015) G van der Plasse et al.   INTERNATIONAL JOURNAL OF OBESITY

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

(2015) Céline M'Kadmi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin Signalling on Food Reward: A Salient Link Between the Gut and the Mesolimbic System

(2015) M. Perello et al.   JOURNAL OF NEUROENDOCRINOLOGY

Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials

(2015) José M Garcia et al.   LANCET ONCOLOGY

Site and mechanism of the colokinetic action of the ghrelin receptor agonist, HM01

(2015) K. Naitou et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Stomach-Derived Hormone Ghrelin Increases Impulsive Behavior

(2015) Rozita H Anderberg et al.   NEUROPSYCHOPHARMACOLOGY

Regulation of the mesolimbic dopamine circuit by feeding peptides

(2015) S. Liu et al.   NEUROSCIENCE

Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability

(2015) Marc A. Parent et al.   Frontiers in Behavioral Neuroscience

Ghrelin

(2015) T.D. Müller et al.   Molecular Metabolism

Brain Circuits Mediating the Orexigenic Action of Peripheral Ghrelin: Narrow Gates for a Vast Kingdom

(2015) Agustina Cabral et al.   Frontiers in Endocrinology

Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food

(2014) Anthony P Goldstone et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet

(2014) Matthew R. McFarlane et al.   Cell Metabolism

The continuous infusion of acylated ghrelin enhances growth hormone secretion and worsens glucose metabolism in humans

(2014) F. Broglio et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

(2014) William McCoull et al.   JOURNAL OF MEDICINAL CHEMISTRY

Divergent Neuronal Circuitries Underlying Acute Orexigenic Effects of Peripheral or Central Ghrelin: Critical Role of Brain Accessibility

(2014) A. Cabral et al.   JOURNAL OF NEUROENDOCRINOLOGY

Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131

(2014) Lex Van der Ploeg et al.   LIFE SCIENCES

Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry

(2014) Zhenyu Sheng et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

New ghrelin agonist, HM01 alleviates constipation and L-dopa-delayed gastric emptying in 6-hydroxydopamine rat model of Parkinson's disease

(2014) H. Karasawa et al.   NEUROGASTROENTEROLOGY AND MOTILITY

High Trait Impulsivity Predicts Food Addiction-Like Behavior in the Rat

(2014) Clara Velázquez-Sánchez et al.   NEUROPSYCHOPHARMACOLOGY

“Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior

(2014) Johannes Hebebrand et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Ghrelin Modulates the fMRI BOLD Response of Homeostatic and Hedonic Brain Centers Regulating Energy Balance in the Rat

(2014) Miklós Sárvári et al.   PLoS One

Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats

(2014) Magdalena Sustkova-Fiserova et al.   PSYCHOPHARMACOLOGY

Ghrelin Alleviates Neuropathic Pain Through GHSR-1a–Mediated Suppression of the p38 MAPK/NF-κB Pathway in a Rat Chronic Constriction Injury Model

(2014) Cheng-Hua Zhou et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile

(2014) Claudio Pietra et al.   Journal of Cachexia Sarcopenia and Muscle

Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014

(2014) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

The Central Nervous System Sites Mediating the Orexigenic Actions of Ghrelin

(2013) B.L. Mason et al.   Annual Review of Physiology

The Addictive Dimensionality of Obesity

(2013) Nora D. Volkow et al.   BIOLOGICAL PSYCHIATRY

The Ghrelin Agonist RM-131 Accelerates Gastric Emptying of Solids and Reduces Symptoms in Patients With Type 1 Diabetes Mellitus

(2013) Andrea Shin et al.   Clinical Gastroenterology and Hepatology

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

(2013) K. M. Heppner et al.   DIABETES

The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects

(2013) Jenny Tong et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Effect of application route of the ghrelin analog BIM-28131 (RM-131) on body weight and body composition in a rat heart failure model

(2013) Sandra Palus et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Human Experience With Ghrelin Administration

(2013) Margaret C. Garin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Macimorelin (AEZS-130)-Stimulated Growth Hormone (GH) Test: Validation of a Novel Oral Stimulation Test for the Diagnosis of Adult GH Deficiency

(2013) J. M. Garcia et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The anorexia of ageing: Physiopathology, prevalence, associated comorbidity and mortality. A systematic review

(2013) Vincenzo Malafarina et al.   MATURITAS

Hypothalamic glucagon signaling inhibits hepatic glucose production

(2013) Patricia I Mighiu et al.   NATURE MEDICINE

Divergent circuitry underlying food reward and intake effects of ghrelin: Dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake

(2013) Karolina P. Skibicka et al.   NEUROPHARMACOLOGY

Food-related impulsivity in obesity and Binge Eating Disorder - a systematic review

(2013) K. Schag et al.   Obesity Reviews

In vivo characterization of the effects of ghrelin on the modulation of acute pain at the supraspinal level in mice

(2013) Jie Wei et al.   PEPTIDES

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

(2013) Marie Schaeffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

(2013) Matei Bolborea et al.   TRENDS IN NEUROSCIENCES

Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans

(2013) Kuniko Takagi et al.   Nature Communications

GHS-R1a constitutive activity and its physiological relevance

(2013) Yves Mear et al.   Frontiers in Neuroscience

Actions of Agonists and Antagonists of the ghrelin/GHS-R Pathway on GH Secretion, Appetite, and cFos Activity

(2013) Rim Hassouna et al.   Frontiers in Endocrinology

Ghrelin is neuroprotective in Parkinson’s disease: molecular mechanisms of metabolic neuroprotection

(2013) Jacqueline A. Bayliss et al.   Therapeutic Advances in Endocrinology and Metabolism

Pharmacological characterization of the ghrelin receptor mediating its inhibitory action on inflammatory pain in rats

(2012) Valeria Sibilia et al.   AMINO ACIDS

Hindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance

(2012) Harvey J. Grill et al.   Cell Metabolism

Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans

(2012) A. Benso et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

MECHANISMS IN ENDOCRINOLOGY: Ghrelin: the differences between acyl- and des-acyl ghrelin

(2012) Patric J D Delhanty et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Promiscuous Dimerization of the Growth Hormone Secretagogue Receptor (GHS-R1a) Attenuates Ghrelin-mediated Signaling

(2012) Harriët Schellekens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering a neuronal circuit that mediates appetite

(2012) Qi Wu et al.   NATURE

Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

(2012) Andras Kern et al.   NEURON

Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system

(2012) Yukie Kawahara et al.   NEUROPHARMACOLOGY

Ghrelin signalling and obesity: At the interface of stress, mood and food reward

(2012) Harriët Schellekens et al.   PHARMACOLOGY & THERAPEUTICS

The Amygdala as a Neurobiological Target for Ghrelin in Rats: Neuroanatomical, Electrophysiological and Behavioral Evidence

(2012) Mayte Alvarez-Crespo et al.   PLoS One

A relationship between motilin and growth hormone secretagogue receptors

(2012) Hiroaki Nunoi et al.   REGULATORY PEPTIDES

Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study

(2012) José M. Garcia et al.   SUPPORTIVE CARE IN CANCER

Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression

(2011) Karolina P. Skibicka et al.   ADDICTION BIOLOGY

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

(2011) Ligen Lin et al.   AGING CELL

Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting - randomised clinical study subset data

(2011) J. M. Wo et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol preference

(2011) Sara Landgren et al.   BEHAVIOURAL BRAIN RESEARCH

Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamus

(2011) Paul J. Currie et al.   BEHAVIOURAL BRAIN RESEARCH

Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice

(2011) Elisabet Jerlhag et al.   DRUG AND ALCOHOL DEPENDENCE

Implication of the melanocortin-3 receptor in the regulation of food intake

(2011) Boman G. Irani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mutually Opposite Signal Modulation by Hypothalamic Heterodimerization of Ghrelin and Melanocortin-3 Receptors

(2011) Anne Rediger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Interaction Pattern for a Functionally Biased Ghrelin Receptor Agonist

(2011) Bjørn Sivertsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin mediates stress-induced food-reward behavior in mice

(2011) Jen-Chieh Chuang et al.   JOURNAL OF CLINICAL INVESTIGATION

Optimization of the Potency and Pharmacokinetic Properties of a Macrocyclic Ghrelin Receptor Agonist (Part I): Development of Ulimorelin (TZP-101) from Hit to Clinic

(2011) Hamid R. Hoveyda et al.   JOURNAL OF MEDICINAL CHEMISTRY

The global obesity pandemic: shaped by global drivers and local environments

(2011) Boyd A Swinburn et al.   LANCET

Ghrelin and cachexia: Will treatment with GHSR-1a agonists make a difference for patients suffering from chronic wasting syndromes?

(2011) Mark D. DeBoer   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The ghrelin axis in disease: Potential therapeutic indications

(2011) Ralf Nass et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The role of the central ghrelin system in reward from food and chemical drugs

(2011) Suzanne L. Dickson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The truncated ghrelin receptor polypeptide (GHS-R1b) is localized in the endoplasmic reticulum where it forms heterodimers with ghrelin receptors (GHS-R1a) to attenuate their cell surface expression

(2011) Kevin B.S. Chow et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

GSK1614343, a Novel Ghrelin Receptor Antagonist, Produces an Unexpected Increase of Food Intake and Body Weight in Rodents and Dogs

(2011) Vivian J.A. Costantini et al.   NEUROENDOCRINOLOGY

Reward Mechanisms in Obesity: New Insights and Future Directions

(2011) Paul J. Kenny   NEURON

Ghrelin directly targets the ventral tegmental area to increase food motivation

(2011) K.P. Skibicka et al.   NEUROSCIENCE

Investigation of the presence of ghrelin in the central nervous system of the rat and mouse

(2011) J.B. Furness et al.   NEUROSCIENCE

Ghrelin and food reward: The story of potential underlying substrates

(2011) Karolina P. Skibicka et al.   PEPTIDES

Beyond the metabolic role of ghrelin: A new player in the regulation of reproductive function

(2011) Giampiero Muccioli et al.   PEPTIDES

Central mechanisms involved in the orexigenic actions of ghrelin

(2011) Zane B. Andrews   PEPTIDES

Leptin and the Central Nervous System Control of Glucose Metabolism

(2011) Gregory J. Morton et al.   PHYSIOLOGICAL REVIEWS

The Ghrelin Signalling System Is Involved in the Consumption of Sweets

(2011) Sara Landgren et al.   PLoS One

Ablations of Ghrelin and Ghrelin Receptor Exhibit Differential Metabolic Phenotypes and Thermogenic Capacity during Aging

(2011) Xiaojun Ma et al.   PLoS One

Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model

(2011) Sandra Palus et al.   PLoS One

Low-dose ghrelin infusion — Evidence against a hormonal role in food intake

(2011) Florian Lippl et al.   REGULATORY PEPTIDES

Hedonic and incentive signals for body weight control

(2011) Emil Egecioglu et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Ghrelin increases intake of rewarding food in rodents

(2010) Emil Egecioglu et al.   ADDICTION BIOLOGY

MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: A multicenter, randomized, placebo-controlled phase IIb study

(2010) Abraham Adunsky et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients

(2010) Kent Lundholm et al.   CANCER

Final Answer: Ghrelin Can Suppress Insulin Secretion in Humans, but Is It Clinically Relevant?

(2010) C. Meyer   DIABETES

Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans

(2010) J. Tong et al.   DIABETES

Identification and Characterization of Acyl-Protein Thioesterase 1/Lysophospholipase I As a Ghrelin Deacylation/Lysophospholipid Hydrolyzing Enzyme in Fetal Bovine Serum and Conditioned Medium

(2010) Motoyasu Satou et al.   ENDOCRINOLOGY

Des-Acyl Ghrelin Has Specific Binding Sites and Different Metabolic Effects from Ghrelin in Cardiomyocytes

(2010) Pamela V. Lear et al.   ENDOCRINOLOGY

Weight Gain Is Associated with Reduced Striatal Response to Palatable Food

(2010) E. Stice et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study

(2010) N. Ejskjaer et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain dopaminergic neurons

(2010) V. Coizet et al.   NEUROSCIENCE

Enhanced c-Fos expression in superior colliculus, paraventricular thalamus and septum during learning of cue-reward association

(2010) K.M. Igelstrom et al.   NEUROSCIENCE

Effects of repeated administered ghrelin on chronic constriction injury of the sciatic nerve in rats

(2010) Ensari Guneli et al.   NEUROSCIENCE LETTERS

Focus on the short- and long-term effects of ghrelin on energy homeostasis

(2010) Carine De Vriese et al.   NUTRITION

Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity

(2010) Angie M. Cason et al.   PHYSIOLOGY & BEHAVIOR

Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin

(2010) Rajesh Kumar et al.   REGULATORY PEPTIDES

Growth Hormone Releasing Peptide-2, a Ghrelin Agonist, Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Rats

(2010) Guang Li et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

The extra-hypothalamic actions of ghrelin on neuronal function

(2010) Zane B. Andrews   TRENDS IN NEUROSCIENCES

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction

(2009) Gary Aston-Jones et al.   BRAIN RESEARCH

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

Ghrelin in Central Neurons

(2009) F. Ferrini et al.   Current Neuropharmacology

Gut Peptides: Targets for Antiobesity Drug Development?

(2009) Timothy H. Moran et al.   ENDOCRINOLOGY

Brain-Endocrine Interactions: A Microvascular Route in the Mediobasal Hypothalamus

(2009) Philippe Ciofi et al.   ENDOCRINOLOGY

In VivoCharacterization of High Basal Signaling from the Ghrelin Receptor

(2009) Pia Steen Petersen et al.   ENDOCRINOLOGY

Metabolic hormones, dopamine circuits, and feeding

(2009) Nandakumar S. Narayanan et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers

(2009) José M. Garcia et al.   GROWTH HORMONE & IGF RESEARCH

Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes

(2009) A Rodríguez et al.   INTERNATIONAL JOURNAL OF OBESITY

Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism

(2009) Z. B. Andrews et al.   JOURNAL OF NEUROSCIENCE

Homeostatic and Hedonic Signals Interact in the Regulation of Food Intake

(2009) Michael Lutter et al.   JOURNAL OF NUTRITION

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

(2009) S. Charoenthongtrakul et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sustained appetite improvement in malnourished dialysis patients by daily ghrelin treatment

(2009) Damien R. Ashby et al.   KIDNEY INTERNATIONAL

Ghrelin Induces Abdominal Obesity Via GHS-R-Dependent Lipid Retention

(2009) Jeffrey S. Davies et al.   MOLECULAR ENDOCRINOLOGY

GOAT links dietary lipids with the endocrine control of energy balance

(2009) Henriette Kirchner et al.   NATURE MEDICINE

Lean mean fat reducing “ghrelin” machine: Hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity

(2009) Harriët Schellekens et al.   NEUROPHARMACOLOGY

Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states

(2009) Y. Kawahara et al.   NEUROSCIENCE

Orexin-A and ghrelin depolarize the same pedunculopontine tegmental neurons in rats: An in vitro study

(2009) Juhyon Kim et al.   PEPTIDES

Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: Role as regulators of food intake and body weight

(2009) Andreas Stengel et al.   PEPTIDES

Motilin and ghrelin as prokinetic drug targets

(2009) Betty De Smet et al.   PHARMACOLOGY & THERAPEUTICS

Requirement of central ghrelin signaling for alcohol reward

(2009) E. Jerlhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the ghrelin receptor to regulate food intake

(2009) Inge Depoortere   REGULATORY PEPTIDES

Characterization of a novel ghrelin cell reporter mouse

(2009) Ichiro Sakata et al.   REGULATORY PEPTIDES

Stress-induced obesity and the emotional nervous system

(2009) Mary F. Dallman   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine

(2008) Elisabet Jerlhag   ADDICTION BIOLOGY

Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats

(2008) Sabine Strassburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study

(2008) F Strasser et al.   BRITISH JOURNAL OF CANCER

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Ghrelin Gets Its GOAT

(2008) James Gardiner et al.   Cell Metabolism

Hypothalamic Neural Projections Are Permanently Disrupted in Diet-Induced Obese Rats

(2008) Sebastien G. Bouret et al.   Cell Metabolism

Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

(2008) Saima Malik et al.   Cell Metabolism

Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake

(2008) D. A. Sandoval et al.   DIABETES

Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases

(2008) Gareth J. Sanger   DRUG DISCOVERY TODAY

Pharmacological Demarcation of the Growth Hormone, Gut Motility and Feeding Effects of Ghrelin Using a Novel Ghrelin Receptor Agonist

(2008) Graeme L. Fraser et al.   ENDOCRINOLOGY

The Gastrointestinal Hormone Ghrelin Modulates Inhibitory Neurotransmission in Deep Laminae of Mouse Spinal Cord Dorsal Horn

(2008) Angela M. Vergnano et al.   ENDOCRINOLOGY

Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite.

(2008) Takashi Akamizu et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus

(2008) Graeme L. Fraser et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Twenty-Four Hour Continuous Ghrelin Infusion Augments Physiologically Pulsatile, Nycthemeral, and Entropic (Feedback-Regulated) Modes of Growth Hormone Secretion

(2008) Johannes D. Veldhuis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Estrogen Elevates the Peak Overnight Production Rate of Acylated Ghrelin

(2008) Remberto C. Paulo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men

(2008) Jianhua Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ghrelin Agonist (TZP-101): Safety, Pharmacokinetics and Pharmacodynamic Evaluation in Healthy Volunteers: A Phase I, First-in-Human Study

(2008) Kenneth C. Lasseter et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacological targeting of the serotonergic system for the treatment of obesity

(2008) Alastair S. Garfield et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reviews in Molecular Biology and Biotechnology: Transmembrane Signaling by G Protein-Coupled Receptors

(2008) Louis M. Luttrell   MOLECULAR BIOTECHNOLOGY

Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation

(2008) a. d. shafton et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Widespread reward-system activation in obese women in response to pictures of high-calorie foods

(2008) Luke E. Stoeckel et al.   NEUROIMAGE

Emergence of ghrelin as a treatment for cachexia syndromes

(2008) Mark Daniel DeBoer   NUTRITION

Central and Peripheral Regulation of Food Intake and Physical Activity: Pathways and Genes

(2008) Natalie R. Lenard et al.   Obesity

Ghrelin, des-acyl ghrelin and obestatin: Three pieces of the same puzzle

(2008) João-Bruno Soares et al.   PEPTIDES

Mechanisms of action of CCK to activate central vagal afferent terminals

(2008) Richard C. Rogers et al.   PEPTIDES

Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats

(2008) Tobias Inhoff et al.   PEPTIDES

Ghrelin infused into the portal vein inhibits glucose-stimulated insulin secretion in Wistar rats

(2008) Can Cui et al.   PEPTIDES

Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood–brain barrier

(2008) William A. Banks et al.   PEPTIDES

Electrophysiological effects of ghrelin on pedunculopontine tegmental neurons in rats: An in vitro study

(2008) Juhyon Kim et al.   PEPTIDES

Novel approaches to the treatment of cachexia

(2007) J ARGILES   DRUG DISCOVERY TODAY

Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance

(2007) Yuxiang Sun et al.   ENDOCRINOLOGY

Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake

(2007) Nicole M. Avena et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Visualization of ghrelin-producing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice

(2007) Haruaki Kageyama et al.   REGULATORY PEPTIDES

The Nonpeptide Growth Hormone Secretagogue, MK-0677, Activates Hypothalamic Arcuate Nucleus Neurons in vivo

(2003) Bailey et al.   JOURNAL OF NEUROENDOCRINOLOGY