Immune checkpoint blockade combined with IL-6 and TGF-β inhibition improves the therapeutic outcome of mRNA-based immunotherapy
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Immune checkpoint blockade combined with IL-6 and TGF-β inhibition improves the therapeutic outcome of mRNA-based immunotherapy
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 143, Issue 3, Pages 686-698
Publisher
Wiley
Online
2018-02-22
DOI
10.1002/ijc.31331
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells
- (2017) Hung-Chang Chen et al. IMMUNOLOGY AND CELL BIOLOGY
- Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation
- (2017) Su Yeon Lee et al. Molecular Cancer
- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
- (2017) Tsukasa Shibue et al. Nature Reviews Clinical Oncology
- Transforming growth factor β as regulator of cancer stemness and metastasis
- (2016) Claudia Bellomo et al. BRITISH JOURNAL OF CANCER
- Radiation-Induced Dedifferentiation of Head and Neck Cancer Cells Into Cancer Stem Cells Depends on Human Papillomavirus Status
- (2016) Erina Vlashi et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model
- (2016) Gina Lee et al. MOLECULAR CANCER THERAPEUTICS
- Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
- (2016) Shohei Koyama et al. Nature Communications
- Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours
- (2016) Lukasz Bialkowski et al. Scientific Reports
- Optimized Stem Cell Detection Using the DyeCycle-Triggered Side Population Phenotype
- (2016) Maximilian Boesch et al. Stem Cells International
- Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer
- (2016) Ruea-Yea Huang et al. OncoImmunology
- DNA Repair and Cytokines: TGF-β, IL-6, and Thrombopoietin as Different Biomarkers of Radioresistance
- (2016) Lucia Centurione et al. Frontiers in Oncology
- Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy
- (2016) Maarten Swart et al. Frontiers in Oncology
- Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital Tract
- (2015) Y.-Y. Sun et al. CLINICAL CANCER RESEARCH
- Safety and Antitumor Activity of Anti–PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer
- (2015) Junzo Hamanishi et al. JOURNAL OF CLINICAL ONCOLOGY
- Repositioned to kill stem cells
- (2015) Tessa Holyoake et al. NATURE
- LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
- (2015) Ruea-Yea Huang et al. Oncotarget
- Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors
- (2015) Francesca De Felice et al. Journal of Immunology Research
- Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma
- (2014) Rebecca Favaro et al. CANCER RESEARCH
- Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy
- (2014) B Auffinger et al. CELL DEATH AND DIFFERENTIATION
- Antitumor DNA vaccination against the Sox2 transcription factor
- (2014) INGRID POLAKOVA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
- (2014) Soufiane Boumahdi et al. NATURE
- The two faces of IL-6 in the tumor microenvironment
- (2014) Daniel T. Fisher et al. SEMINARS IN IMMUNOLOGY
- Regulatory T cell subsets in human cancer: are they regulating for or against tumor progression?
- (2013) Theresa L. Whiteside CANCER IMMUNOLOGY IMMUNOTHERAPY
- Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
- (2013) Seog-Young Kim et al. CELLULAR SIGNALLING
- TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
- (2013) Neil E. Bhola et al. JOURNAL OF CLINICAL INVESTIGATION
- Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy
- (2013) Christel Devaud et al. MOLECULAR THERAPY
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors
- (2013) F. Sandoval et al. Science Translational Medicine
- Dynamic equilibrium between cancer stem cells and non-stem cancer cells in human SW620 and MCF-7 cancer cell populations
- (2012) G Yang et al. BRITISH JOURNAL OF CANCER
- Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity
- (2012) N. Ning et al. CANCER RESEARCH
- CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma
- (2012) P. A. Prieto et al. CLINICAL CANCER RESEARCH
- Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
- (2012) Jennifer Landsberg et al. NATURE
- Transforming Growth Factor β1 Signal is Crucial for Dedifferentiation of Cancer Cells to Cancer Stem Cells in Osteosarcoma
- (2012) Haixia Zhang et al. STEM CELLS
- The cancer stem cell niche-there goes the neighborhood?
- (2011) Stephanie M. Cabarcas et al. INTERNATIONAL JOURNAL OF CANCER
- Guidelines for the welfare and use of animals in cancer research
- (2010) P Workman et al. BRITISH JOURNAL OF CANCER
- Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients
- (2010) T. Di Tomaso et al. CLINICAL CANCER RESEARCH
- Interleukin-6 in bone metastasis and cancer progression
- (2010) Tasnim Ara et al. EUROPEAN JOURNAL OF CANCER
- Natural immunity to pluripotency antigen OCT4 in humans
- (2010) K. M. Dhodapkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
- (2010) M. A. Curran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer stem cells: mirage or reality?
- (2009) Piyush B Gupta et al. NATURE MEDICINE
- An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
- (2008) Ittai Ben-Porath et al. NATURE GENETICS
- Mechanisms of Disease: cancer stem cells—targeting the evil twin
- (2008) Andreas Trumpp et al. Nature clinical practice. Oncology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation