MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

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An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

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Targeting Mitochondria-Derived Reactive Oxygen Species to Reduce Epithelial Barrier Dysfunction and Colitis

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PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

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Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

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Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

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Mitochondrial Gene Polymorphisms That Protect Mice From Colitis

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Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis

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Software for Computing and Annotating Genomic Ranges

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Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models

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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

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The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

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Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

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Mitochondria at the Interface Between Danger Signaling and Metabolism: Role of Unfolded Protein Responses in Chronic Inflammation

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Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

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The role of mitochondria in insulin resistance and type 2 diabetes mellitus

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Ulcerative Colitis

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Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

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Characterization of intestinal gene expression profiles in Crohnʼs disease by genome-wide microarray analysis

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A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

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The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

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Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

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Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

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