Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Mast Cells Contribute to Autoimmune Inflammatory Arthritis via Their Tryptase/Heparin Complexes

(2014) K. Shin et al.   JOURNAL OF IMMUNOLOGY

Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase of Trichinella spiralis Infection

(2014) K. Shin et al.   JOURNAL OF IMMUNOLOGY

Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice

(2012) M. Komai-Koma et al.   ALLERGY

The Chymase Mouse Mast Cell Protease 4 Degrades TNF, Limits Inflammation, and Promotes Survival in a Model of Sepsis

(2012) Adrian M. Piliponsky et al.   AMERICAN JOURNAL OF PATHOLOGY

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

A case of mistaken identity: HSPs are no DAMPs but DAMPERs

(2011) Willem van Eden et al.   CELL STRESS & CHAPERONES

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice

(2011) Mitsuteru Akahoshi et al.   JOURNAL OF CLINICAL INVESTIGATION

Mast Cells as Sensors of Cell Injury through IL-33 Recognition

(2011) M. Enoksson et al.   JOURNAL OF IMMUNOLOGY

Mast cell proteases: multifaceted regulators of inflammatory disease

(2010) G. Pejler et al.   BLOOD

Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+memory T cells

(2010) Nadja Fischer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse Mast Cell Protease 4 Is the Major Chymase in Murine Airways and Has a Protective Role in Allergic Airway Inflammation

(2009) I. Waern et al.   JOURNAL OF IMMUNOLOGY

At the Crossroads of Bacterial Metabolism and Virulence Factor Synthesis in Staphylococci

(2009) G. A. Somerville et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism

(2009) Katherine R. Groschwitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis

(2008) Sofia E. Magnusson et al.   FASEB JOURNAL

The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile

(2008) M. K. Andersson et al.   INTERNATIONAL IMMUNOLOGY

Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis

(2008) Adrian M Piliponsky et al.   NATURE MEDICINE

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One

The extended cleavage specificity of the rodent β-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase

(2007) Mattias K. Andersson et al.   MOLECULAR IMMUNOLOGY