Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B

Chromosome 14q imbalances and pathways associated with resistance to antiangiogenic therapy in clear cell renal cell carcinoma.

(2017) E. Jonasch et al.   JOURNAL OF CLINICAL ONCOLOGY

The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

(2016) W. Liang et al.   Cancer Immunology Research

Tryptase, a novel angiogenic factor stored in mast cell granules

(2015) Domenico Ribatti et al.   EXPERIMENTAL CELL RESEARCH

Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs

(2015) Isabel Ben-Batalla et al.   Oncotarget

Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia

(2015) Sabine Cerny-Reiterer et al.   Oncotarget

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

(2015) Lyubov Zaitseva et al.   Oncotarget

Modeling Pharmacological Inhibition of Mast Cell Degranulation as a Therapy for Insulinoma

(2015) Laura Soucek et al.   NEOPLASIA

Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions

(2014) Naveen S. Vasudev et al.   ANGIOGENESIS

Survival after neoadjuvant chemotherapy with or without bevacizumab or everolimus for HER2-negative primary breast cancer (GBG 44–GeparQuinto)†

(2014) G. von Minckwitz et al.   ANNALS OF ONCOLOGY

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Monocyte Subpopulations in Angiogenesis

(2014) H. J. Dalton et al.   CANCER RESEARCH

Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism

(2014) Peter Stapor et al.   JOURNAL OF CELL SCIENCE

Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability

(2014) Alon Hendel et al.   LABORATORY INVESTIGATION

Cooperative Heparin-Mediated Oligomerization of Fibroblast Growth Factor-1 (FGF1) Precedes Recruitment of FGFR2 to Ternary Complexes

(2013) Alan Brown et al.   BIOPHYSICAL JOURNAL

Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties

(2013) Françoise Bono et al.   CANCER CELL

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

(2012) A. Facciabene et al.   CANCER RESEARCH

Controlling angiogenesis in breast cancer: A systematic review of anti-angiogenic trials

(2012) John R. Mackey et al.   CANCER TREATMENT REVIEWS

Evidence questioning cromolyn’s effectiveness and selectivity as a ‘mast cell stabilizer’ in mice

(2012) Tatsuya Oka et al.   LABORATORY INVESTIGATION

Neoadjuvant Chemotherapy and Bevacizumab for HER2-Negative Breast Cancer

(2012) Gunter von Minckwitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

New models for analyzing mast cell functions in vivo

(2012) Laurent L. Reber et al.   TRENDS IN IMMUNOLOGY

Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APC 468 Mice

(2011) E. C. Cheon et al.   CANCER RESEARCH

Mast Cell Targeting Hampers Prostate Adenocarcinoma Development but Promotes the Occurrence of Highly Malignant Neuroendocrine Cancers

(2011) P. Pittoni et al.   CANCER RESEARCH

Mast Cells Increase Vascular Permeability by Heparin-Initiated Bradykinin Formation In Vivo

(2011) Chris Oschatz et al.   IMMUNITY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Mast cell proteases: multifaceted regulators of inflammatory disease

(2010) G. Pejler et al.   BLOOD

Sunitinib

(2009) Georgios S. Papaetis et al.   BIODRUGS

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Interactions between extracellular matrix and growth factors in wound healing

(2009) Gregory S. Schultz et al.   WOUND REPAIR AND REGENERATION

Genetic Inversion in Mast Cell-Deficient Wsh Mice Interrupts Corin and Manifests as Hematopoietic and Cardiac Aberrancy

(2008) Peter A. Nigrovic et al.   AMERICAN JOURNAL OF PATHOLOGY

Antihemostatic Activity of Human Granzyme B Mediated by Cleavage of von Willebrand Factor

(2008) Marguerite S. Buzza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The FGF system has a key role in regulating vascular integrity

(2008) Masahiro Murakami et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitronectin: Growth Factor Complexes Hold Potential as a Wound Therapy Approach

(2008) Zee Upton et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Multicolor Panel of Novel Lentiviral “Gene Ontology” (LeGO) Vectors for Functional Gene Analysis

(2008) Kristoffer Weber et al.   MOLECULAR THERAPY

Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation

(2008) K. Takagi et al.   NEUROSCIENCE

Tumor Angiogenesis

(2008) Robert S. Kerbel   NEW ENGLAND JOURNAL OF MEDICINE