HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder

CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization

(2016) Mohammad Sarfaraz Nawaz et al.   PLoS One

Regulation of hippocampal synaptic plasticity by BDNF

(2015) Graciano Leal et al.   BRAIN RESEARCH

There is variability in the attainment of developmental milestones in the CDKL5 disorder

(2015) Stephanie Fehr et al.   Journal of Neurodevelopmental Disorders

Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder

(2015) Claudia Fuchs et al.   NEUROBIOLOGY OF DISEASE

Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid

(2015) Berry Juliandi et al.   Stem Cell Reports

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling

(2014) Claudia Fuchs et al.   NEUROBIOLOGY OF DISEASE

Myocyte enhancer factor 2C regulation of hepatocellular carcinoma via vascular endothelial growth factor and Wnt/β-catenin signaling

(2014) X L Bai et al.   ONCOGENE

Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder

(2014) Elena Amendola et al.   PLoS One

Identification of amphiphysin 1 as an endogenous substrate for CDKL5, a protein kinase associated with X-linked neurodevelopmental disorder

(2013) Mari Sekiguchi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Region-specific expression of brain-derived neurotrophic factor splice variants in morphine conditioned place preference in mice

(2013) Min Meng et al.   BRAIN RESEARCH

The Amyloid Precursor Protein (APP) Triplicated Gene Impairs Neuronal Precursor Differentiation and Neurite Development through Two Different Domains in the Ts65Dn Mouse Model for Down Syndrome

(2013) Stefania Trazzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential regulation of Bdnf expression in cortical neurons by class-selective histone deacetylase inhibitors

(2013) Indrek Koppel et al.   NEUROPHARMACOLOGY

Monoaminergic and Neuropeptidergic Neurons Have Distinct Expression Profiles of Histone Deacetylases

(2013) Kenkichi Takase et al.   PLoS One

Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development

(2013) Y.-C. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

(2013) Michal Mielcarek et al.   PLOS BIOLOGY

Recurrent mutations in theCDKL5gene: Genotype-phenotype relationships

(2012) Nadia Bahi-Buisson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells

(2012) Emanuele Valli et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Early Pharmacotherapy with Fluoxetine Rescues Dendritic Pathology in the Ts65Dn Mouse Model of Down Syndrome

(2012) Sandra Guidi et al.   BRAIN PATHOLOGY

HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

(2012) Richard Sando et al.   CELL

The CDKL5 disorder is an independent clinical entity associated with early-onset encephalopathy

(2012) Stephanie Fehr et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Notch3 and Mef2c Proteins Are Mutually Antagonistic via Mkp1 Protein and miR-1/206 MicroRNAs in Differentiating Myoblasts

(2012) Jeffrey Gagan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase (HDAC) Inhibitors with a Novel Connecting Unit Linker Region Reveal a Selectivity Profile for HDAC4 and HDAC5 with Improved Activity against Chemoresistant Cancer Cells

(2012) Linda Marek et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation

(2012) M.-S. Kim et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylases and cancer

(2012) Bruna Barneda-Zahonero et al.   Molecular Oncology

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1–PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons

(2012) Sara Ricciardi et al.   NATURE CELL BIOLOGY

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

(2012) Jiali Li et al.   NATURE MEDICINE

The Role of MeCP2 in the Brain

(2011) Jacky Guy et al.   Annual Review of Cell and Developmental Biology

Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer

(2011) K Ted Thurn et al.   Future Oncology

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

(2011) Stefania Trazzi et al.   HUMAN MOLECULAR GENETICS

Identification of a novel CDKL5 exon and pathogenic mutations in patients with severe mental retardation, early-onset seizures and Rett-like features

(2011) Nils Rademacher et al.   NEUROGENETICS

Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function

(2011) Sonia Cohen et al.   NEURON

Adult Neural Function Requires MeCP2

(2011) C. M. McGraw et al.   SCIENCE

Histone deacetylases as targets for the treatment of human neurodegenerative diseases

(2010) S.R. D'Mello   DRUG NEWS & PERSPECTIVES

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates

(2010) Ya-Li Yao et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The C-Terminal Domain of CENP-C Displays Multiple and Critical Functions for Mammalian Centromere Formation

(2009) Stefania Trazzi et al.   PLoS One

Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1

(2008) Isamu Kameshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

The three stages of epilepsy in patients withCDKL5mutations

(2008) Nadia Bahi-Buisson et al.   EPILEPSIA

The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity

(2008) Todd J. Cohen et al.   FASEB JOURNAL

CDKL5 Expression Is Modulated during Neuronal Development and Its Subcellular Distribution Is Tightly Regulated by the C-terminal Tail

(2008) Laura Rusconi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Class IIA HDACs in the regulation of neurodegeneration

(2007) Nazanin Majdzadeh   Frontiers in Bioscience-Landmark