Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

(2016) Jeongeun Hyun et al.   Nature Communications

Intracellular Sphingosine 1-Phosphate Contributes to Collagen Expression of Hepatic Myofibroblasts in Human Liver Fibrosis Independent of Its Receptors

(2015) Lei Xiu et al.   AMERICAN JOURNAL OF PATHOLOGY

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program

(2015) Shicheng Su et al.   Nature Communications

Cellular and molecular mechanisms in liver fibrogenesis

(2014) Erica Novo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway

(2014) Xiaolong Tu et al.   JOURNAL OF PATHOLOGY

Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis

(2013) Long Shuang Huang et al.   FASEB JOURNAL

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis

(2013) Le Yang et al.   JOURNAL OF HEPATOLOGY

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Bone Marrow-Derived Mesenchymal Stem Cells Differentiate to Hepatic Myofibroblasts by Transforming Growth Factor-β1 via Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis

(2012) Le Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases

(2012) Stephanie Schwalm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis

(2012) Sara Galastri et al.   CLINICAL SCIENCE

Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis

(2012) Ashley M. Lakner et al.   HEPATOLOGY

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

(2011) Takahiro Kodama et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility

(2010) Changyong Li et al.   JOURNAL OF HEPATOLOGY

Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis

(2010) Henning W. Zimmermann et al.   PLoS One

Involvement of Sphingosine 1-Phosphate (SIP)/S1P 3 Signaling in Cholestasis-Induced Liver Fibrosis

(2009) Changyong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice

(2009) Claudia Mitchell et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

(2009) N. Gellings Lowe et al.   CARDIOVASCULAR RESEARCH

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Chemokine (C-C motif) receptors in fibrogenesis and hepatic regeneration following acute and chronic liver disease

(2009) Grant A. Ramm   HEPATOLOGY

CCR2 promotes hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   HEPATOLOGY

Nanomedicine based approaches for the delivery of siRNA in cancer

(2009) B. Ozpolat et al.   JOURNAL OF INTERNAL MEDICINE

Sphingosine kinase-1: a potential mediator of renal fibrosis

(2009) David A. Long et al.   KIDNEY INTERNATIONAL

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY