MicroRNA-21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

(2017) Shanshan Zhang et al.   JOURNAL OF HEPATOLOGY

Absence of microRNA-21 does not reduce muscular dystrophy in mouse models of LAMA2-CMD

(2017) Bernardo Moreira Soares Oliveira et al.   PLoS One

Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma

(2016) Xueru Mu et al.   GASTROENTEROLOGY

Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice

(2016) Lindsey L Kennedy et al.   LABORATORY INVESTIGATION

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches

(2016) Julia Beermann et al.   PHYSIOLOGICAL REVIEWS

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells

(2015) J. Zhang et al.   CANCER RESEARCH

High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers

(2015) Ingmar Mederacke et al.   Nature Protocols

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Origin and Function of Myofibroblasts in the Liver

(2015) Robert Schwabe et al.   SEMINARS IN LIVER DISEASE

Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells

(2015) Mar Coll et al.   Scientific Reports

The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis

(2015) Joeri Lambrecht et al.   Frontiers in Physiology

Aberrant Regulation and Function of MicroRNAs in Cancer

(2014) Brian D. Adams et al.   CURRENT BIOLOGY

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

MicroRNA-21 in Glomerular Injury

(2014) J. Y. Lai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

The Autoregulatory Feedback Loop of MicroRNA-21/Programmed Cell Death Protein 4/Activation Protein-1 (MiR-21/PDCD4/AP-1) as a Driving Force for Hepatic Fibrosis Development

(2013) Zhengping Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs in liver disease

(2013) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

MicroRNAs in Liver Disease

(2012) Xin Wei Wang et al.   GASTROENTEROLOGY

A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration

(2012) Raymond Ng et al.   JOURNAL OF CLINICAL INVESTIGATION

Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver

(2012) J. R. Androsavich et al.   RNA

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

(2012) B. N. Chau et al.   Science Translational Medicine

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Comparison of different miR-21 inhibitor chemistries in a cardiac disease model

(2011) Thomas Thum et al.   JOURNAL OF CLINICAL INVESTIGATION

Response to Thum et al.

(2011) David M. Patrick et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis

(2011) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21

(2010) Mark E. Hatley et al.   CANCER CELL

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

(2010) David M. Patrick et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

(2010) Gang Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

(2010) Pedro P. Medina et al.   NATURE

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

(2009) Florin M. Selaru et al.   HEPATOLOGY

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations

(2008) Yannick Ladeiro et al.   HEPATOLOGY

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE