3′ UTR lengthening as a novel mechanism in regulating cellular senescence

Alternative Polyadenylation: Methods, Findings, and Impacts

(2017) Wei Chen et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Dynamic landscape of alternative polyadenylation during retinal development

(2016) Wenyan Hu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genome-wide dynamics of alternative polyadenylation in rice

(2016) Haihui Fu et al.   GENOME RESEARCH

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells

(2016) Yonit Hoffman et al.   PLoS Genetics

Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization

(2015) Binyamin D. Berkovits et al.   NATURE

Knocking down the expression of TRA2β inhibits the proliferation and migration of human glioma cells

(2015) Lixiang Yang et al.   PATHOLOGY RESEARCH AND PRACTICE

Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

(2015) Yu-Ning Wei et al.   GENOME BIOLOGY

The effects of aging on the expression of Wnt pathway genes in mouse tissues

(2014) Jeffrey W. Hofmann et al.   AGE

Cellular senescence and protein degradation

(2014) Xavier Deschênes-Simard et al.   CELL CYCLE

Endothelial Cell Senescence and Age-Related Vascular Diseases

(2014) Xiao-Li Tian et al.   Journal of Genetics and Genomics

The hallmarks of fibroblast ageing

(2014) Julia Tigges et al.   MECHANISMS OF AGEING AND DEVELOPMENT

KNDC1 knockdown protects human umbilical vein endothelial cells from senescence

(2014) CHUNYAN ZHANG et al.   Molecular Medicine Reports

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RBPmap: a web server for mapping binding sites of RNA-binding proteins

(2014) Inbal Paz et al.   NUCLEIC ACIDS RESEARCH

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

(2014) Zheng Xia et al.   Nature Communications

Implications of time-series gene expression profiles of replicative senescence

(2013) You-Mi Kim et al.   AGING CELL

Distinct polyadenylation landscapes of diverse human tissues revealed by a modified PA-seq strategy

(2013) Ting Ni et al.   BMC GENOMICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Stressing the cell cycle in senescence and aging

(2013) Hollie Chandler et al.   CURRENT OPINION IN CELL BIOLOGY

FOXA1 mediates p16INK4a activation during cellular senescence

(2013) Qian Li et al.   EMBO JOURNAL

Widespread splicing changes in human brain development and aging

(2013) P. Mazin et al.   Molecular Systems Biology

Alternative cleavage and polyadenylation: extent, regulation and function

(2013) Ran Elkon et al.   NATURE REVIEWS GENETICS

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence

(2012) Anna Cardus et al.   CARDIOVASCULAR RESEARCH

Dynamic landscape of tandem 3' UTRs during zebrafish development

(2012) Y. Li et al.   GENOME RESEARCH

Extensive alternative polyadenylation during zebrafish development

(2012) I. Ulitsky et al.   GENOME RESEARCH

A quantitative atlas of polyadenylation in five mammals

(2012) Adnan Derti et al.   GENOME RESEARCH

An in-depth map of polyadenylation sites in cancer

(2012) Yuefeng Lin et al.   NUCLEIC ACIDS RESEARCH

Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila

(2012) Peter Smibert et al.   Cell Reports

E2F mediates enhanced alternative polyadenylation in proliferation

(2012) Ran Elkon et al.   GENOME BIOLOGY

Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing

(2011) Y. Fu et al.   GENOME RESEARCH

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Mechanisms and Consequences of Alternative Polyadenylation

(2011) Dafne Campigli Di Giammartino et al.   MOLECULAR CELL

Transcriptional activity regulates alternative cleavage and polyadenylation

(2011) Z. Ji et al.   Molecular Systems Biology

Neural-specific elongation of 3' UTRs during Drosophila development

(2011) V. Hilgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Evolutionarily Conserved Exons as Regulated Targets for the Splicing Activator Tra2β in Development

(2011) Sushma Grellscheid et al.   PLoS Genetics

Molecular mechanisms of eukaryotic pre-mRNA 3′ end processing regulation

(2010) Stefania Millevoi et al.   NUCLEIC ACIDS RESEARCH

The Landscape of C. elegans 3'UTRs

(2010) M. Mangone et al.   SCIENCE

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Transcriptome analysis by strand-specific sequencing of complementary DNA

(2009) Dmitri Parkhomchuk et al.   NUCLEIC ACIDS RESEARCH

Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development

(2009) Z. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Role of Insulin-Like Growth Factor Binding Protein-3 in Human Umbilical Vein Endothelial Cell Senescence

(2008) Christoph Muck et al.   REJUVENATION RESEARCH

Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

(2008) R. Sandberg et al.   SCIENCE

Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome

(2008) J. Zhao et al.   SCIENCE