Carbonic anhydrase activators

Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators

(2017) Suleyman Akocak et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Psychoactive substances belonging to the amphetamine class potently activate brain carbonic anhydrase isoforms VA, VB, VII, and XII

(2017) Andrea Angeli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Treatment of Rheumatoid Arthritis

(2017) Silvia Bua et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus

(2017) Lucas Canto de Souza et al.   NEUROPHARMACOLOGY

Structure and function of carbonic anhydrases

(2016) C. T. Supuran   BIOCHEMICAL JOURNAL

Dynamic encapsulation and activation of carbonic anhydrase in multivalent dynameric host matrices

(2016) Yan Zhang et al.   CHEMICAL COMMUNICATIONS

Indazole, Pyrazole, and Oxazole Derivatives Targeting Nitric Oxide Synthases and Carbonic Anhydrases

(2016) Cristina Maccallini et al.   ChemMedChem

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

(2016) Francesca Margheri et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A class of carbonic anhydrase I – selective activators

(2016) Erol Licsandru et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

(2015) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors

(2015) Lorenzo Di Cesare Mannelli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

How many carbonic anhydrase inhibition mechanisms exist?

(2015) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Mitochondrial Carbonic Anhydrase VA Deficiency Resulting from CA5A Alterations Presents with Hyperammonemia in Early Childhood

(2014) Clara D. van Karnebeek et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators

(2014) Mohamed-Chiheb Saada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum —The η-carbonic anhydrases

(2014) Sonia Del Prete et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dominant behaviours in the expression of human carbonic anhydrase hCA I activity

(2014) M. Yahia M. Abdelrahim et al.   CHEMICAL COMMUNICATIONS

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

(2014) Bogdan Draghici et al.   CHEMICAL COMMUNICATIONS

Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles

(2014) Mayank Aggarwal et al.   IUCrJ

Induction of carbonic anhydrase in SaOS-2 cells, exposed to bicarbonate and consequences for calcium phosphate crystal formation

(2013) Werner E.G. Müller et al.   BIOMATERIALS

Modulation of the Initial Mineralization Process of SaOS-2 Cells by Carbonic Anhydrase Activators and Polyphosphate

(2013) Xiaohong Wang et al.   CALCIFIED TISSUE INTERNATIONAL

Antiglaucoma carbonic anhydrase inhibitors: a patent review

(2013) Emanuela Masini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013)

(2013) Simona Maria Monti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antiobesity carbonic anhydrase inhibitors: a literature and patent review

(2013) Andrea Scozzafava et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

(2013) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO2 capture

(2013) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines

(2012) Daniela Vullo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Structure-based drug discovery of carbonic anhydrase inhibitors

(2012) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives

(2011) Mohamed-Chiheb Saada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms

(2011) Mohamed-Chiheb Saada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Rescue of Enzymes: Proton Transfer in Mutants of Human Carbonic Anhydrase II

(2011) C. Mark Maupin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII

(2011) Khyati Dave et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hyperchlorhidrosis Caused by Homozygous Mutation in CA12, Encoding Carbonic Anhydrase XII

(2010) Maya Feldshtein et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Timolol Activates the Enzyme Activities of Human Carbonic Anhydrase I and II

(2010) Ayako Sugimoto et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II

(2010) Khyati Dave et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Saccharomyces cerevisiae β-Carbonic Anhydrase: Inhibition and Activation Studies

(2010) Semra Isika et al.   CURRENT PHARMACEUTICAL DESIGN

Progressive renal injury from transgenic expression of human carbonic anhydrase IV folding mutants is enhanced by deficiency of p58IPK

(2010) R. Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Archetype γ-Class Carbonic Anhydrase (Cam) Contains Iron When Synthesized in Vivo†

(2009) Sheridan R. MacAuley et al.   BIOCHEMISTRY

Small-Molecule Suppression of Misfolding of Mutated Human Carbonic Anhydrase II Linked to Marble Brain Disease

(2009) Karin Almstedt et al.   BIOCHEMISTRY

The γ class of carbonic anhydrases

(2009) James G. Ferry   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sequestration of carbon dioxide by the hydrophobic pocket of the carbonic anhydrases

(2009) John F. Domsic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I–XIV

(2009) T. Abdülkadir Coban et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase activators: Activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives

(2009) Marie-Rose Abdo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase activators: Activation of the human tumor-associated isozymes IX and XII with amino acids and amines

(2008) Silvia Pastorekova et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I–XIV

(2008) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines

(2008) Daniela Vullo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase activators: Activation of the archaeal β-class (Cab) and γ-class (Cam) carbonic anhydrases with amino acids and amines

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diuretics: From Classical Carbonic Anhydrase Inhibitors to Novel Applications of the Sulfonamides

(2008) Claudiu Supuran   CURRENT PHARMACEUTICAL DESIGN

Carbonic Anhydrase Activation and the Drug Design

(2008) Claudia Temperini et al.   CURRENT PHARMACEUTICAL DESIGN

Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms

(2008) Yan Xu et al.   NATURE

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY