Article
Pharmacology & Pharmacy
Apiwan Arinno, Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Sasiwan Kerdphoo, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Studies have shown that melatonin and metformin can reduce oxidative stress, inflammation, autophagy, apoptosis, and improve mitochondrial function to protect against Doxorubicin-induced cardiotoxicity.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nisar Ahmad, Arfan Ullah, Peng Chu, Wenzhang Tian, Zeyao Tang, Zhaolin Sun
Summary: Doxorubicin is a commonly prescribed chemotherapeutic drug worldwide, but its use is limited by harmful side effects like cardiotoxicity. This review paper focuses on the cardiomyopathy and cardiomyocyte death induced by DOX, as well as the roles of SIRT1, SIRT3, and DOX in modulating mitochondrial processes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Pharmacology & Pharmacy
Tanawat Attachaipanich, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Doxorubicin is an effective chemotherapeutic drug, but its clinical application is limited due to cardiotoxicity. Melatonin has been shown to protect against doxorubicin-induced cardiotoxicity by attenuating oxidative stress and modulating cell death pathways. However, further clinical studies are needed to evaluate the efficacy of melatonin in reducing doxorubicin-induced cardiotoxicity.
Article
Endocrinology & Metabolism
Chanisa Thonusin, Wichwara Nawara, Apiwan Arinno, Thawatchai Khuanjing, Nanthip Prathumsup, Benjamin Ongnok, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Using mass spectrometry-based targeted metabolomics, this study aimed to investigate the patterns of cardiac metabolic reprogramming and energetics in doxorubicin-induced heart failure, as well as the potential effects of melatonin on these processes. The results showed that co-treatment with melatonin could restore cardiac function, glucose and ketone body utilization, and adenosine triphosphate production, while also increasing cardiac fatty acid oxidation, branched-chain amino acid catabolism, and anaplerosis. These findings highlight the potential efficacy of melatonin in cardiac metabolic reprogramming and energetics, suggesting it as an adjunctive treatment for doxorubicin-induced heart failure.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Jean C. Bikomeye, Janee D. Terwoord, Janine H. Santos, Andreas M. Beyer
Summary: Anticancer therapies can have cardiotoxic side effects, with mitochondrial damage being a key factor. Further research is needed to understand the secondary signaling events that occur in response to such damage, as mitochondria also play important roles in other pathologies.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Wei Zhang, Xi Wang, Yanhong Tang, Congxin Huang
Summary: Melatonin has cardioprotective effects on various cardiovascular diseases, including doxorubicin-induced cardiomyopathy. It has been shown to enhance mitochondrial function and mitigate myocardial injuries caused by Doxorubicin, but its role in regulating the Sirt1/Nrf2 pathway in lessening the onset of cardiomyopathy is still unclear.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Apiwan Arinno, Chayodom Maneechote, Thawatchai Khuanjing, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Wichwara Nawara, Sasiwan Kerdphoo, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This study aims to investigate the protective effects of melatonin and metformin against trastuzumab-induced cardiac injury. The results demonstrate that both melatonin and metformin can attenuate trastuzumab-induced cardiac injury and improve cardiac function.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Pharmacology & Pharmacy
Thawatchai Khuanjing, Benjamin Ongnok, Chayodom Maneechote, Natthaphat Siri-Angkul, Nanthip Prathumsap, Apiwan Arinno, Titikorn Chunchai, Busarin Arunsak, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: The study showed that donepezil can alleviate doxorubicin-induced cardiotoxicity, reduce cardiac damage, and improve cardiac function.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Wei Luo, Xiaoyi Zou, Yidan Wang, Zheng Dong, Xinyu Weng, Zhiqiang Pei, Shuai Song, Yongchao Zhao, Zilun Wei, Rifeng Gao, Beijian Zhang, Liwei Liu, Peiyuan Bai, Jin Liu, Xiang Wang, Tingwen Gao, Yang Zhang, Xiaolei Sun, Hang Chen, Kai Hu, Shisuo Du, Aijun Sun, Junbo Ge
Summary: The cardiac EC cGAS-STING pathway plays a critical role in doxorubicin-induced cardiotoxicity by reducing NAD levels and causing mitochondrial dysfunction. Targeting this pathway could be a potential therapeutic strategy for preventing cardiotoxicity.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yaodong Yi, Hengbin Zhang, Mingyang Chen, Binxin Chen, Yingchun Chen, Ping Li, Hui Zhou, Zhiyuan Ma, Huidi Jiang
Summary: Doxorubicin (DOX) is commonly used for tumor treatment, but its cardiotoxicity limits its use. We investigated the mechanisms of DOX uptake and found that OCTN1/OCTN2/PMAT play crucial roles in DOX uptake in cardiomyocytes and mitochondria. Metformin effectively reduced DOX concentration and toxicity by inhibiting DOX uptake transporters without affecting its efflux. Additionally, metformin dose-dependently reduced DOX accumulation in mouse myocardium and attenuated its cardiotoxicity, without impairing DOX efficacy in cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, Research & Experimental
Farshid Maleki, Mona Salimi, Reza Shirkoohi, Mohsen Rezaei
Summary: Transplantation of freshly isolated mitochondria into cardiomyocytes damaged by doxorubicin has been shown to significantly reduce the toxicity of doxorubicin on the heart and improve cell viability.
Article
Cell Biology
Weili Li, Xiaoping Wang, Tianhua Liu, Qian Zhang, Jing Cao, Yanyan Jiang, Qianbin Sun, Chun Li, Wei Wang, Yong Wang
Summary: Doxorubicin is an effective chemotherapeutic agent, but its clinical use is limited due to the severe risk of cardiotoxicity. This study finds that harpagoside has significant cardioprotective effects in DICT mouse and rat cardiomyocytes by targeting the interaction between p53 and Parkin to restore mitophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gang Li, Ming Chu, Yingying Tong, Yuexin Liang, Shenghui Wang, Chengjun Ma, Zhenhua Wang, Wenna Zhou
Summary: This study found that phenylpropanoid compounds extracted from sea buckthorn can significantly alleviate Doxorubicin-induced cardiac injury in zebrafish by stabilizing mitochondrial biogenesis and function.
Article
Cell Biology
Jing Zhao, Hua-qing Yu, Feng-qin Ge, Man-ru Zhang, Yu-chen Song, Dan-dan Guo, Qi-hang Li, Hua Zhu, Peng-zhou Hang
Summary: It has been found that 7,8,3'-Trihydroxyflavone (THF) can alleviate doxorubicin (DOX)-induced cardiotoxicity and improve mitochondrial function by activating Akt-mediated Mfn2 and HO-1 pathways.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Yihai Liu, Xuan Wei, Mingyue Wu, Jiamin Xu, Biao Xu, Lina Kang
Summary: The study found that BHB could protect from DOX-induced cardiotoxicity by inhibiting cell apoptosis and oxidative stress, and maintaining mitochondrial membrane integrity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ilze Mentoor, A-M Engelbrecht, Theo Nell
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2019)
Review
Oncology
Toni Leigh Mortimer, Tom Mabin, Anna-Mart Engelbrecht
Article
Multidisciplinary Sciences
Martin J. Page, Greig J. A. Thomson, J. Massimo Nunes, Anna-Mart Engelbrecht, Theo A. Nell, Willem J. S. de Villiers, Maria C. de Beer, Lize Engelbrecht, Douglas B. Kell, Etheresia Pretorius
SCIENTIFIC REPORTS
(2019)
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Biochemistry & Molecular Biology
Gustav van Niekerk, Tanja Davis, Hugh-George Patterton, Anna-Mart Engelbrecht
Article
Oncology
Carla Fourie, Tanja Davis, Jurgen Kriel, Anna-Mart Engelbrecht
EXPERIMENTAL CELL RESEARCH
(2019)
Editorial Material
Cell Biology
Ben Loos, Daniel J. Klionsky, Andre Du Toit, Jan-Hendrik S. Hofmeyr
Review
Biochemistry & Molecular Biology
Gustav van Niekerk, Claudia Christowitz, Daleen Conradie, Anna-Mart Engelbrecht
CYTOKINE & GROWTH FACTOR REVIEWS
(2020)
Article
Biotechnology & Applied Microbiology
Thandi Mqoco, Andre Stander, Anna-Mart Engelbrecht, Anna M. Joubert
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Cell Biology
Sholto de Wet, Andre Du Toit, Ben Loos
Summary: The text discusses autophagy flux, specific autophagy targeting mechanisms, the role of receptor proteins in autophagy, and the effects of rapamycin and spermidine on autophagy activity. The study reveals that autophagosome turnover and specific cargo clearance are distinct entities with inherent properties, each contributing differently to total autophagy activity.
Review
Biochemistry & Molecular Biology
M. du Plessis, T. Davis, B. Loos, E. Pretorius, W. J. S. de Villiers, A. M. Engelbrecht
Summary: Chronic inflammation plays a crucial role in tumor progression and metastasis, with dysregulation of key physiological processes such as autophagy contributing to unfavorable immune responses. Serum amyloid A (SAA) in high levels in the tumor microenvironment can promote cancer initiation and progression by activating signaling pathways like PI3K and MAPK. Autophagy, on the other hand, can have both promoting and inhibiting effects on cancer development, and its regulation is crucial for improving cancer therapy outcomes.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Review
Immunology
Michelle Van der Merwe, Gustav Van Niekerk, Alf Botha, Anna-Mart Engelbrecht
Summary: Breast cancer is often associated with bacterial dysbiosis, particularly oral dysbiosis. Fusobacterium nucleatum may promote breast cancer progression by activating specific pathways and suppressing the immune system.
IMMUNOLOGY LETTERS
(2021)
Article
Oncology
Daniel Wilhelm Olivier, Etheresia Pretorius, Anna-Mart Engelbrecht
Summary: This study investigated the role of SAA1 in TNBC, focusing on cell cycle regulation, apoptosis, survival signaling, metabolism, and metastasis. Knockdown of SAA1 had varying effects in different cell types, with potential for therapeutic targeting in TNBC.
EXPERIMENTAL CELL RESEARCH
(2021)
Letter
Nutrition & Dietetics
Gustav van Niekerk, Anna-Mart Engelbrecht
CLINICAL NUTRITION ESPEN
(2019)
Article
Cell Biology
Jenna Susan Bleloch, Andre du Toit, Liezl Gibhard, Serah Kimani, Reyna Deeya Ballim, Minkyu Lee, Angelique Blanckenberg, Selwyn Mapolie, Lubbe Wiesner, Ben Loos, Sharon Prince
CELL DEATH DISCOVERY
(2019)
Article
Multidisciplinary Sciences
Marguerite Blignaut, Ben Loos, Stanley W. Botchway, Anthony W. Parker, Barbara Huisamen
SCIENTIFIC REPORTS
(2019)
