Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

(2022) Jeremy Di Domizio et al.   NATURE

A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis

(2022) Dan Zhang et al.   NATURE CELL BIOLOGY

Coronary microcirculation damage in anthracycline cardiotoxicity

(2021) Carlos Galán-Arriola et al.   CARDIOVASCULAR RESEARCH

GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury

(2021) Huairui Shi et al.   CIRCULATION RESEARCH

A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

(2021) Daipayan Banerjee et al.   Nature Communications

Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy

(2020) Kendall B. Wallace et al.   CIRCULATION RESEARCH

Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure

(2020) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

NAD+ metabolism and its roles in cellular processes during ageing

(2020) Anthony J. Covarrubias et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities

(2019) Jie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture

(2019) Wei Luo et al.   CIRCULATION

TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis

(2019) Lele Zhu et al.   NATURE CELL BIOLOGY

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD + Decline

(2018) Mariana G. Tarragó et al.   Cell Metabolism

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Palmitic acid dysregulates the Hippo–YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS–STING–IRF3 signaling mechanism

(2017) Liangshuai Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD38 promotes angiotensin II-induced cardiac hypertrophy

(2017) Xiao-Hui Guan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE

(2016) Dan L. Li et al.   CIRCULATION

A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse HeartNovelty and Significance

(2016) Matthew Ackers-Johnson et al.   CIRCULATION RESEARCH

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection

(2016) Markus Räsänen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability

(2016) Emma L. Wilkinson et al.   Biology Open

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

(2015) Levy A. Reyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies

(2014) J. Deckert et al.   CLINICAL CANCER RESEARCH

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Revealing CD38 Cellular Localization Using a Cell Permeable, Mechanism-Based Fluorescent Small-Molecule Probe

(2014) Jonathan H. Shrimp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

(2012) Christian K Holm et al.   NATURE IMMUNOLOGY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

The Membrane-Bound Enzyme CD38 Exists in Two Opposing Orientations

(2012) Y. J. Zhao et al.   Science Signaling

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice

(2010) Chengqun Huang et al.   CIRCULATION

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY