Extracellular histones in tissue injury and inflammation

Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis

(2014) D. N. Douda et al.   BLOOD

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histone 3.3 Participates in a Self-Sustaining Cascade of Apoptosis That Contributes to the Progression of Chronic Obstructive Pulmonary Disease

(2013) Carlos A. Barrero et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs

(2013) G R Wickman et al.   CELL DEATH AND DIFFERENTIATION

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

Nucleosomes and neutrophil activation in sickle cell disease painful crisis

(2013) M. Schimmel et al.   HAEMATOLOGICA

Circulating histones exacerbate inflammation in mice with acute liver failure

(2013) Zongmei Wen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

The Pathogenesis of Lupus Nephritis

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

(2013) Mayumi Nakahara et al.   PLoS One

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

(2013) C. L. Case et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Functional responses and molecular mechanisms involved in histone-mediated platelet activation

(2013) Marìa Albertina Romaniuk et al.   THROMBOSIS AND HAEMOSTASIS

Histone induced platelet aggregation is inhibited by normal albumin

(2013) Fong W. Lam et al.   THROMBOSIS RESEARCH

Neutrophils release extracellular DNA traps during storage of red blood cell units

(2013) Tobias A. Fuchs et al.   TRANSFUSION

Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction

(2012) Mark R. Gillrie et al.   AMERICAN JOURNAL OF PATHOLOGY

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

(2012) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Circulating nucleosomes and severity of illness in children suffering from meningococcal sepsis treated with protein C

(2012) Sacha Zeerleder et al.   CRITICAL CARE MEDICINE

Extracellular histones inhibit hair shaft elongation in cultured human hair follicles and promote regression of hair follicles in mice

(2012) Seung Hyun Shin et al.   EXPERIMENTAL DERMATOLOGY

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Dying Cells and Extracellular Histones in AKI: Beyond a NET Effect?

(2012) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Uromodulin Triggers IL-1 -Dependent Innate Immunity via the NLRP3 Inflammasome

(2012) M. N. Darisipudi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Extracellular histone release in response to traumatic injury

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

A novel pathogenetic concept—antiviral immunity in lupus nephritis

(2012) Adriana Migliorini et al.   Nature Reviews Nephrology

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

(2011) Nishant Dwivedi et al.   ARTHRITIS AND RHEUMATISM

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Systemic Lupus Erythematosus and the Neutrophil

(2011) Xavier Bosch   NEW ENGLAND JOURNAL OF MEDICINE

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Differential Microbicidal Effects of Human Histone Proteins H2A and H2B onLeishmaniaPromastigotes and Amastigotes

(2010) Yingwei Wang et al.   INFECTION AND IMMUNITY

In Vitro Interactions of Extracellular Histones with LDL Suggest a Potential Pro-Atherogenic Role

(2010) Alan D. Pemberton et al.   PLoS One

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H4 Is a Major Component of the Antimicrobial Action of Human Sebocytes

(2009) Dong-Youn Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nephritogenic Potential of Anti-DNA Antibodies against Necrotic Nucleosomes

(2009) E. S. Mortensen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis

(2009) P. A. Monach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lupus Nephritis

(2008) Elin S. Mortensen et al.   AMERICAN JOURNAL OF PATHOLOGY