The role of IL-23 receptor signaling in inflammation-mediated erosive autoimmune arthritis and bone remodeling

IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus

(2017) Hong Dai et al.   JOURNAL OF IMMUNOLOGY

Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double-Blind, Active Comparator- and Placebo-Controlled Study

(2017) Francisco J. Blanco et al.   Arthritis & Rheumatology

IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis

(2016) Eric Gracey et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin (IL)-9/IL-9R axis drives γδ T cells activation in psoriatic arthritis patients

(2016) G. Guggino et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Optimizing therapy in inflammatory arthritis: prediction of relapse after tapering or stopping treatment for rheumatoid arthritis patients achieving clinical and radiological remission

(2016) Y. El Miedany et al.   CLINICAL RHEUMATOLOGY

Quantitative imaging by pixel-based contrast-enhanced ultrasound reveals a linear relationship between synovial vascular perfusion and the recruitment of pathogenic IL-17A-F+IL-23+ CD161+ CD4+ T helper cells in psoriatic arthritis joints

(2016) Ugo Fiocco et al.   CLINICAL RHEUMATOLOGY

Loss of IL-22 inhibits autoantibody formation in collagen-induced arthritis in mice

(2016) Odilia B. J. Corneth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Investigation of association of the IL-12B and IL-23R genetic variations with psoriatic risk in a South Indian Tamil cohort

(2016) S. Indhumathi et al.   HUMAN IMMUNOLOGY

IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking

(2016) Durga Sivanesan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of LTB4/BLT1 in IL-23–Induced Synovial Inflammation and Osteoclastogenesis via NF-κB

(2016) Laura Bouchareychas et al.   JOURNAL OF IMMUNOLOGY

Efficacy and Safety of Subcutaneous and Intravenous Loading Dose Regimens of Secukinumab in Patients with Active Rheumatoid Arthritis: Results from a Randomized Phase II Study

(2016) W. Tlustochowicz et al.   JOURNAL OF RHEUMATOLOGY

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease

(2016) René Pfeifle et al.   NATURE IMMUNOLOGY

IL-23 assists the transition from autoimmunity to inflammatory disease

(2016) M. Teresa Villanueva   Nature Reviews Rheumatology

Brief Report: Secukinumab Provides Significant and Sustained Inhibition of Joint Structural Damage in a Phase III Study of Active Psoriatic Arthritis

(2016) Désirée van der Heijde et al.   Arthritis & Rheumatology

Interleukin-23-Dependent γ/δ T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice

(2016) Annika Reinhardt et al.   Arthritis & Rheumatology

Effect of denosumab on Japanese patients with rheumatoid arthritis: a dose–response study of AMG 162 (Denosumab) in patients withRheumatoId arthritis on methotrexate toValidate inhibitory effect on boneErosion (DRIVE)—a 12-month, multicentre, randomised, double-blind, placebo-controlled, phase II clinical trial

(2015) Tsutomu Takeuchi et al.   ANNALS OF THE RHEUMATIC DISEASES

Animal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside—a Comprehensive Review

(2015) C. Henrique Alves et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The role and modulation of CCR6+ Th17 cell populations in rheumatoid arthritis

(2015) Sandra M.J. Paulissen et al.   CYTOKINE

Macrophages derived from THP-1 promote the osteogenic differentiation of mesenchymal stem cells through the IL-23/IL-23R/β-catenin pathway

(2015) Bing Tu et al.   EXPERIMENTAL CELL RESEARCH

Evidence of association of interleukin-23 receptor gene polymorphisms with Egyptian rheumatoid arthritis patients

(2015) Gehan Hamdy et al.   HUMAN IMMUNOLOGY

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity

(2015) Patrick R. Burkett et al.   JOURNAL OF CLINICAL INVESTIGATION

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2015) Iain B McInnes et al.   LANCET

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(2015) Karin Andersson et al.   MOLECULAR MEDICINE

The IL-23–IL-17 axis in inflammatory arthritis

(2015) Erik Lubberts   Nature Reviews Rheumatology

Interleukin-23 in early disease development in rheumatoid arthritis

(2015) T Andersen et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis

(2015) Juan D. Cañete et al.   ARTHRITIS RESEARCH & THERAPY

Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial

(2014) Christopher Ritchlin et al.   ANNALS OF THE RHEUMATIC DISEASES

Ustekinumab, an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials

(2014) Arthur Kavanaugh et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-17A, IL-17F and IL-23R Gene Polymorphisms in Polish Patients with Rheumatoid Arthritis

(2014) Katarzyna Bogunia-Kubik et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Generalized bone loss in early rheumatoid arthritis patients followed for ten years in the biologic treatment era

(2014) Glenn Haugeberg et al.   BMC MUSCULOSKELETAL DISORDERS

IL-23R gene polymorphism rs2201841 is associated with psoriatic arthritis

(2014) S. Popadic et al.   International Journal of Immunogenetics

IL-23 Inhibits Osteoclastogenesis Indirectly through Lymphocytes and Is Required for the Maintenance of Bone Mass in Mice

(2014) J. M. W. Quinn et al.   JOURNAL OF IMMUNOLOGY

IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage

(2014) G. L. Stritesky et al.   JOURNAL OF IMMUNOLOGY

IL-23 Induces Receptor Activator of NF- B Ligand Expression on CD4+ T Cells and Promotes Osteoclastogenesis in an Autoimmune Arthritis Model

(2014) J. H. Ju et al.   JOURNAL OF IMMUNOLOGY

Crosstalk among IL-23 and DNAX Activating Protein of 12 kDa–Dependent Pathways Promotes Osteoclastogenesis

(2014) Hyun-Seock Shin et al.   JOURNAL OF IMMUNOLOGY

Interleukin-23 and its correlation with disease activity, joint damage, and functional disability in rheumatoid arthritis

(2014) Adnan Siti Dalila et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

(2014) Lisa GM van Baarsen et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin-23 Mediates the Intestinal Response to Microbial β-1,3-Glucan and the Development of Spondyloarthritis Pathology in SKG Mice

(2014) Helen Benham et al.   Arthritis & Rheumatology

RhoA/ROCK-dependent pathway is required for TLR2-mediated IL-23 production in human synovial macrophages: Suppression by cilostazol

(2013) So Youn Park et al.   BIOCHEMICAL PHARMACOLOGY

Synovial Fibroblasts Directly Induce Th17 Pathogenicity via the Cyclooxygenase/Prostaglandin E2 Pathway, Independent of IL-23

(2013) S. M. J. Paulissen et al.   JOURNAL OF IMMUNOLOGY

IL-23 Dependent and Independent Stages of Experimental Arthritis: No Clinical Effect of Therapeutic IL-23p19 Inhibition in Collagen-induced Arthritis

(2013) Ferry Cornelissen et al.   PLoS One

Intra-articular CD1c-expressing myeloid dendritic cells from rheumatoid arthritis patients express a unique set of T cell-attracting chemokines and spontaneously induce Th1, Th17 and Th2 cell activity

(2013) Frederique M Moret et al.   ARTHRITIS RESEARCH & THERAPY

Th17 and Th22 cells in psoriatic arthritis and psoriasis

(2013) Helen Benham et al.   ARTHRITIS RESEARCH & THERAPY

ACPA and Bone Loss in Rheumatoid Arthritis

(2013) Roland Kocijan et al.   Current Rheumatology Reports

The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation

(2012) Yoon-Sook Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-23: One cytokine in control of autoimmunity

(2012) Andrew L. Croxford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

(2012) Jonathan P Sherlock et al.   NATURE MEDICINE

Altered Bone Biology in Psoriatic Arthritis

(2012) Homaira Rahimi et al.   Current Rheumatology Reports

Pathways for Bone Loss in Inflammatory Disease

(2012) Tobias Braun et al.   Current Osteoporosis Reports

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

(2011) Yihua Cai et al.   IMMUNITY

Th17 Cells, Not IL-17+    T Cells, Drive Arthritic Bone Destruction in Mice and Humans

(2011) B. Pollinger et al.   JOURNAL OF IMMUNOLOGY

IL-23 Is Critical for Induction of Arthritis, Osteoclast Formation, and Maintenance of Bone Mass

(2011) I. E. Adamopoulos et al.   JOURNAL OF IMMUNOLOGY

IL-17 receptor and its functional significance in psoriatic arthritis

(2011) Siba P. Raychaudhuri et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritis

(2010) Adriana M. C. Mus et al.   ARTHRITIS AND RHEUMATISM

Polymorphisms of the IL23R Gene Are Associated with Psoriasis but not with Immunoglobulin A Nephropathy in a Hungarian Population

(2010) Eniko Safrany et al.   INFLAMMATION

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

IL-23 induces receptor activator of NF-κB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-κB signal pathways

(2009) Xia Li et al.   IMMUNOLOGY LETTERS

Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORγt in γδ T cells

(2009) Ferry Cornelissen et al.   ARTHRITIS RESEARCH & THERAPY

Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits, p19 and p40, in rheumatoid arthritis

(2008) F Brentano et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis

(2008) J E Hollis-Moffatt et al.   ANNALS OF THE RHEUMATIC DISEASES

The inflammatory disease–associated variants inIL12B andIL23R are not associated with rheumatoid arthritis

(2008) Monica Chang et al.   ARTHRITIS AND RHEUMATISM

IL-23 promotes osteoclast formation by up-regulation of receptor activator of NF-κB (RANK) expression in myeloid precursor cells

(2008) Li Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility

(2008) Jeong Ha Park et al.   RHEUMATOLOGY INTERNATIONAL