Journal
CURRENT RHEUMATOLOGY REPORTS
Volume 14, Issue 4, Pages 349-357Publisher
SPRINGER
DOI: 10.1007/s11926-012-0259-1
Keywords
Psoriatic arthritis; Ankylosing spondylitis; Osteoclastogenesis; Osteoblastogenesis; New bone formation; Bone biology; Imaging
Categories
Ask authors/readers for more resources
Psoriatic arthritis (PsA) is characterized by focal bone erosions mediated by osteoclasts at the bone-pannus junction. The bulk of research over the past decade has centered on mechanisms that underlie osteoclastogenesis along with new insights into osteoimmunology; however, recent advances that focus on steps that lead to new bone formation are beginning to emerge. New revelations about bone formation may have direct relevance to PsA given the presence of enthesophytes, syndesmophytes, and bony ankylosis frequently observed in patients with this disorder. In this review, we discuss current developments in the pathogenesis of new bone formation, novel imaging approaches to study bone remodeling and highlight innovative approaches to study the effect of inflammation on bone. Lastly, we discuss promising therapies that target joint inflammation and osteitis with the potential to mediate pathologic bone formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available