The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses

Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines

(2016) Laura E. Noges et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity

(2016) Motoi Kobayashi et al.   Scientific Reports

IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

(2015) Ewa Oleszycka et al.   FEBS Journal

IL-33 released by alum is responsible for early cytokine production and has adjuvant properties

(2015) William A. Rose II et al.   Scientific Reports

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection

(2015) Aisling F. Brown et al.   PLoS Pathogens

Immunomodulatory properties of the vaccine adjuvant alum

(2014) Ewa Oleszycka et al.   CURRENT OPINION IN IMMUNOLOGY

Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation

(2014) Graham A. Tynan et al.   DIABETES

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

The Adjuvants Aluminum Hydroxide and MF59 Induce Monocyte and Granulocyte Chemoattractants and Enhance Monocyte Differentiation toward Dendritic Cells

(2014) A. Seubert et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonization requires both humoral and cellular immune responses

(2014) R Wilson et al.   Mucosal Immunology

Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells

(2013) A. S. McKee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine

(2013) Pádraig J. Ross et al.   PLoS Pathogens

The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses

(2012) Andres Mori et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Blockade of IL-10 Signaling during Bacillus Calmette-Guerin Vaccination Enhances and Sustains Th1, Th17, and Innate Lymphoid IFN-  and IL-17 Responses and Increases Protection to Mycobacterium tuberculosis Infection

(2012) J. M. Pitt et al.   JOURNAL OF IMMUNOLOGY

Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways

(2012) Peter J Murray et al.   NATURE IMMUNOLOGY

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Role of AS04 in human papillomavirus vaccine: mode of action and clinical profile

(2011) Nathalie Garçon et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma

(2011) Mirjam Kool et al.   IMMUNITY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells

(2011) M. K. L. MacLeod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils are significant producers of IL-10 during sepsis

(2010) Kevin R. Kasten et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung

(2010) Paul S. Redford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform

(2010) Patricia A. Darrah et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory B cells: Evidence, developmental origin and population diversity

(2010) Gaetano Vitale et al.   MOLECULAR IMMUNOLOGY

Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation

(2009) Craig L. Maynard et al.   IMMUNOLOGICAL REVIEWS

Interleukin-10: new perspectives on an old cytokine

(2009) David M. Mosser et al.   IMMUNOLOGICAL REVIEWS

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens?

(2009) I. M. Belyakov et al.   JOURNAL OF IMMUNOLOGY

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

(2008) M. Ohtani et al.   BLOOD

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE