Derangements in adrenergic-adipokine signalling establish a neurohormonal basis for obesity-related heart failure with a preserved ejection fraction

Leptin-Aldosterone-Neprilysin Axis

(2018) Milton Packer   CIRCULATION

Effect of eplerenone in patients with heart failure and reduced ejection fraction: potential effect modification by abdominal obesity. Insight from the EMPHASIS-HF trial

(2017) Arnaud Olivier et al.   EUROPEAN JOURNAL OF HEART FAILURE

Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease

(2017) Vaibhav B. Patel et al.   HEART FAILURE REVIEWS

HFpEF and HFrEF exhibit different phenotypes as assessed by leptin and adiponectin

(2017) Ulrika Ljung Faxén et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Hyperleptinemia Exacerbates High-Fat Diet-Mediated Atrial Fibrosis and Fibrillation

(2017) AKIRA FUKUI et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Evolutional change in epicardial fat and its correlation with myocardial diffuse fibrosis in heart failure patients

(2017) Cho-Kai Wu et al.   Journal of Clinical Lipidology

Cardiovascular risk of adipokines: a review

(2017) Frédéric Dutheil et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney

(2017) David J. Polhemus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection FractionCLINICAL PERSPECTIVE

(2017) Camilla Hage et al.   Circulation-Cardiovascular Genetics

Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction

(2017) Scott D. Solomon et al.   JACC-Heart Failure

Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK

(2017) Tetsuya Shiuchi et al.   Scientific Reports

The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity

(2017) Josué Gutiérrez-Tenorio et al.   Scientific Reports

Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes

(2016) Ana Burgeiro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin/glucose induces natriuretic peptide clearance receptor in human adipocytes: a metabolic link with the cardiac natriuretic pathway

(2016) M. Bordicchia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction

(2016) Sanjiv J. Shah et al.   CIRCULATION

Epicardial Adipose Tissue Accumulation Is Associated With Renal Dysfunction and Coronary Plaque Morphology on Multidetector Computed Tomography

(2016) Koki Nakanishi et al.   CIRCULATION JOURNAL

Interstitial Fibrosis, Functional Status, and Outcomes in Heart Failure With Preserved Ejection FractionCLINICAL PERSPECTIVE

(2016) Franz Duca et al.   Circulation-Cardiovascular Imaging

Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes

(2016) Kashyap A. Patel et al.   DIABETES

Soluble neprilysin does not correlate with outcome in heart failure with preserved ejection fraction

(2016) Georg Goliasch et al.   EUROPEAN JOURNAL OF HEART FAILURE

Leptin Mediates High-Fat Diet Sensitization of Angiotensin II–Elicited Hypertension by Upregulating the Brain Renin–Angiotensin System and InflammationNovelty and Significance

(2016) Baojian Xue et al.   HYPERTENSION

The angiotensin II type 1 receptor-neprilysin inhibitor LCZ696 blocked aldosterone synthesis in a human adrenocortical cell line

(2016) Shin-Ichiro Miura et al.   HYPERTENSION RESEARCH

High-Output Heart Failure

(2016) Yogesh N.V. Reddy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac FibrosisCLINICAL PERSPECTIVE

(2015) Anne-Cécile Huby et al.   CIRCULATION

Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms

(2015) J. E. Hall et al.   CIRCULATION RESEARCH

Impaired atrial natriuretic peptide-mediated lipolysis in obesity

(2015) M Rydén et al.   INTERNATIONAL JOURNAL OF OBESITY

p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload

(2015) Yohko Yoshida et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Angiographic Evaluation of Coronary Microvascular Dysfunction in Patients with Heart Failure and Preserved Ejection Fraction

(2015) Vincenzo Sucato et al.   MICROCIRCULATION

Progression of Kidney Injury and Cardiac Remodeling in Obese Spontaneously Hypertensive Rats: The Role of Renal Sympathetic Innervation

(2014) D. Linz et al.   AMERICAN JOURNAL OF HYPERTENSION

Mineralocorticoid Receptor Blockade Improves Coronary Microvascular Function in Individuals With Type 2 Diabetes

(2014) Rajesh Garg et al.   DIABETES

The glucocorticoid receptor, not the mineralocorticoid receptor, plays the dominant role in adipogenesis and adipokine production in human adipocytes

(2014) M-J Lee et al.   INTERNATIONAL JOURNAL OF OBESITY

Genetic and Nongenetic Factors Influencing Pharmacokinetics of B-Type Natriuretic Peptide

(2014) David E. Lanfear et al.   JOURNAL OF CARDIAC FAILURE

Adipocytokines in obesity and metabolic disease

(2014) Haiming Cao   JOURNAL OF ENDOCRINOLOGY

Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress

(2014) Ernesto Martínez-Martínez et al.   JOURNAL OF HYPERTENSION

Noncardiac Comorbidities in Heart Failure With Reduced Versus Preserved Ejection Fraction

(2014) Robert J. Mentz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Spironolactone for Heart Failure with Preserved Ejection Fraction

(2014) Bertram Pitt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leptin into the rostral ventral lateral medulla (RVLM) augments renal sympathetic nerve activity and blood pressure

(2014) Maria J. Barnes et al.   Frontiers in Neuroscience

Increased echocardiographic epicardial fat thickness and high-sensitivity CRP level indicate diastolic dysfunction in patients with newly diagnosed essential hypertension

(2013) Osman Turak et al.   BLOOD PRESSURE MONITORING

Adiponectin and p53 mRNA in epicardial and subcutaneous fat from heart failure patients

(2013) Rosa M. Agra et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Catecholamine Stress Alters Neutrophil Trafficking and Impairs Wound Healing by β 2 -Adrenergic Receptor–Mediated Upregulation of IL-6

(2013) Min-Ho Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inflammation and metabolic dysfunction: links to cardiovascular diseases

(2012) Annika Taube et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Contribution of glucocorticoid–mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction

(2012) Ayumu Hirata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure

(2012) Ippei Shimizu et al.   Cell Metabolism

Effect of nebivolol on outcome in elderly patients with heart failure and atrial fibrillation: insights from SENIORS

(2012) Bart A. Mulder et al.   EUROPEAN JOURNAL OF HEART FAILURE

Adipocytes Produce Aldosterone Through Calcineurin-Dependent Signaling Pathways

(2012) Ana M. Briones et al.   HYPERTENSION

The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial

(2012) Scott D Solomon et al.   LANCET

Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers

(2012) Emma Burgos-Ramos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leptin Plasma Levels in the General Population: Influence of Age, Gender, Body Weight and Medical History

(2012) Stephany Fulda et al.   PROTEIN AND PEPTIDE LETTERS

Leptin’s regulation of obesity-induced cardiac extracellular matrix remodeling

(2011) Sherma Zibadi et al.   Cardiovascular Toxicology

Prognostic Value of Baseline Plasma Amino-Terminal Pro-Brain Natriuretic Peptide and Its Interactions With Irbesartan Treatment Effects in Patients With Heart Failure and Preserved Ejection Fraction

(2011) Inder S. Anand et al.   Circulation-Heart Failure

Adipocyte-Derived Factors Regulate Vascular Smooth Muscle Cells Through Mineralocorticoid and Glucocorticoid Receptors

(2011) Aurelie Nguyen Dinh Cat et al.   HYPERTENSION

Results of the Randomized Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction Trial (RAAM-PEF)

(2011) Anita Deswal et al.   JOURNAL OF CARDIAC FAILURE

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of the mineralocorticoid receptor in adipocyte biology and fat metabolism

(2011) Vincenzo Marzolla et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

β2-Adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern

(2010) Bei Sun et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Neprilysin, obesity and the metabolic syndrome

(2010) K F Standeven et al.   INTERNATIONAL JOURNAL OF OBESITY

The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses

(2009) J Hoppmann et al.   JOURNAL OF ENDOCRINOLOGY

β2 Adrenoreceptor blockade attenuates the hyperinflammatory response induced by traumatic injury

(2009) James Rough et al.   SURGERY

A Comparison of the Aldosterone-blocking Agents Eplerenone and Spironolactone

(2008) Allan Struthers et al.   CLINICAL CARDIOLOGY

Effects of leptin on energy metabolism in β-less mice

(2008) C S Asensio et al.   INTERNATIONAL JOURNAL OF OBESITY