The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity

Epidermal Growth Factor Receptor Transactivation: Mechanisms, Pathophysiology, and Potential Therapies in the Cardiovascular System

(2016) Steven J. Forrester et al.   Annual Review of Pharmacology and Toxicology

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female MiceNovelty and Significance

(2016) Anne-Cécile Huby et al.   HYPERTENSION

The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats

(2016) Ernesto Martínez-Martínez et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment

(2016) Jia Song et al.   Oncotarget

Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac FibrosisCLINICAL PERSPECTIVE

(2015) Anne-Cécile Huby et al.   CIRCULATION

Galectin-3 Participates in Cardiovascular Remodeling Associated With ObesityNovelty and Significance

(2015) Ernesto Martínez-Martínez et al.   HYPERTENSION

Mineralocorticoid Receptor Antagonism Treats Obesity-Associated Cardiac Diastolic Dysfunction

(2015) S. B. Bender et al.   HYPERTENSION

Mineralocorticoid receptor antagonists in heart failure with preserved ejection fraction (HFpEF)

(2015) Annalisa Capuano et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model

(2015) Dandan Liang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Leptin exerts proliferative and anti-apoptotic effects on goose granulosa cells through the PI3K/Akt/mTOR signaling pathway

(2015) Rui Wen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Impact of Galectin-3 Inhibition on Aldosterone-Induced Cardiac and Renal Injuries

(2015) Laurent Calvier et al.   JACC-Heart Failure

Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy

(2014) Jerzy Beltowski et al.   CURRENT PHARMACEUTICAL DESIGN

The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol

(2014) Christine Feillet-Coudray et al.   FREE RADICAL RESEARCH

Features of Cardiac Remodeling, Associated With Blood Pressure and Fibrosis Biomarkers, Are Frequent in Subjects With Abdominal Obesity

(2014) Romain Eschalier et al.   HYPERTENSION

The potential role of leptin in the vascular remodeling associated with obesity

(2014) E Martínez-Martínez et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress

(2014) Ernesto Martínez-Martínez et al.   JOURNAL OF HYPERTENSION

Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

(2014) Michele Cavalera et al.   Translational Research

Fibrosis and cardiac function in obesity: a randomised controlled trial of aldosterone blockade

(2013) Wojciech Kosmala et al.   HEART

Cross-talk between mineralocorticoid receptor/angiotensin II type 1 receptor and mitogen-activated protein kinase pathways underlies aldosterone-induced atrial fibrotic responses in HL-1 cardiomyocytes

(2013) Chin-Feng Tsai et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

(2013) Maren Leifheit-Nestler et al.   Journal of Translational Medicine

The mineralocorticoid receptor-p38MAPK-NFκB or ERK-Sp1 signal pathways mediate aldosterone-stimulated inflammatory and profibrotic responses in rat vascular smooth muscle cells

(2012) Chuan-jiang Zhu et al.   ACTA PHARMACOLOGICA SINICA

Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension

(2012) Sonia Martínez-Revelles et al.   ANTIOXIDANTS & REDOX SIGNALING

Topiramate Treatment Improves Hypothalamic Insulin and Leptin Signaling and Action and Reduces Obesity in Mice

(2012) Andrea M. Caricilli et al.   ENDOCRINOLOGY

Loss of Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells and Cardiomyocytes Causes Arterial Hypotension and Cardiac Hypertrophy

(2012) Barbara Schreier et al.   HYPERTENSION

Aldosterone Induces Kidney Fibroblast Proliferation via Activation of Growth Factor Receptors and PI3K/MAPK Signalling

(2012) L.L. Huang et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Leptin Antagonizes Peroxisome Proliferator-Activated Receptor-γSignaling in Growth Plate Chondrocytes

(2012) Lai Wang et al.   PPAR Research

Leptin’s regulation of obesity-induced cardiac extracellular matrix remodeling

(2011) Sherma Zibadi et al.   Cardiovascular Toxicology

Synergistic Interaction between Leptin and Cholecystokinin in the Rat Nodose Ganglia Is Mediated by PI3K and STAT3 Signaling Pathways

(2011) Andrea Heldsinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary total antioxidant capacity is inversely related to central adiposity as well as to metabolic and oxidative stress markers in healthy young adults

(2011) Helen Hermana M Hermsdorff et al.   Nutrition & Metabolism

A Randomized Study of the Beneficial Effects of Aldosterone Antagonism on LV Function, Structure, and Fibrosis Markers in Metabolic Syndrome

(2011) Wojciech Kosmala et al.   JACC-Cardiovascular Imaging

Regulation of Placental Leptin Expression by Cyclic Adenosine 5′-Monophosphate Involves Cross Talk between Protein Kinase A and Mitogen-Activated Protein Kinase Signaling Pathways

(2010) Julieta L. Maymó et al.   ENDOCRINOLOGY

Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

(2009) Karunakaran Chandran et al.   BIOPHYSICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-κB/p300 binding in human synovial fibroblasts

(2008) Kwok-Man Tong et al.   CELLULAR SIGNALLING