The angiotensin II type 1 receptor-neprilysin inhibitor LCZ696 blocked aldosterone synthesis in a human adrenocortical cell line

LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice

(2016) Yasunori Suematsu et al.   EUROPEAN JOURNAL OF HEART FAILURE

Aldosterone and abnormal left ventricular geometry in chronic kidney disease

(2015) Cesare Cuspidi et al.   HYPERTENSION RESEARCH

Safety and efficacy of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Japanese patients with hypertension and renal dysfunction

(2015) Sadayoshi Ito et al.   HYPERTENSION RESEARCH

Plasma aldosterone and its relationship with left ventricular mass in hypertensive patients with early-stage chronic kidney disease

(2015) Giuseppe Mulè et al.   HYPERTENSION RESEARCH

Comparison of aldosterone synthesis in adrenal cells, effect of various AT1receptor blockers with or without atrial natriuretic peptide

(2014) Shin-ichiro Miura et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Angiotensin II Triggers Expression of the Adrenal Gland Zona Glomerulosa-Specific 3 -Hydroxysteroid Dehydrogenase Isoenzyme through De Novo Protein Synthesis of the Orphan Nuclear Receptors NGFIB and NURR1

(2014) T. Ota et al.   MOLECULAR AND CELLULAR BIOLOGY

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial

(2012) Scott D Solomon et al.   LANCET

Aldosterone and cardiovascular disease: the heart of the matter

(2012) B. Julie He et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Natriuretic peptide metabolism, clearance and degradation

(2011) Lincoln R. Potter   FEBS Journal

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

(2009) Jessie Gu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Regulator of G-Protein Signaling Subtype 4 Mediates Antihypertrophic Effect of Locally Secreted Natriuretic Peptides in the Heart

(2008) Takeshi Tokudome et al.   CIRCULATION