Journal
FERTILITY AND STERILITY
Volume 90, Issue 4, Pages 1269-1271Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2007.07.1373
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Funding
- NICHD NIH HHS [K12-HD01426, K12-HD050128] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [K12HD001426, K12HD050128] Funding Source: NIH RePORTER
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The oocyte-specific G-protein-coupled receptor 3 (GPR3) gene is essential in maintaining meiotic arrest in mouse oocytes. Disruption of GPR3 results in early depletion of oocytes and thus premature ovarian aging. To determine if mutations of the GPR3 gene were present in 82 predominantly North American caucasian women with premature ovarian failure (POF), we used denaturing high-performance liquid chromatography and DNA sequencing to detect sequence variants. None of the 82 POF samples showed perturbations of significance. We conclude that perturbations in GPR3 are not a common explanation for POF in this population.
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