Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models

Loss of HDAC5 Impairs Memory Function: Implications for Alzheimer's Disease

(2018) Roberto Carlos Agis-Balboa et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease

(2015) Robert H. Pietrzak et al.   JAMA Psychiatry

Inside Alzheimer brain with CLARITY: senile plaques, neurofibrillary tangles and axons in 3-D

(2014) Kunie Ando et al.   ACTA NEUROPATHOLOGICA

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

(2014) Eric Karran et al.   ANNALS OF NEUROLOGY

Lessons from a Failed γ-Secretase Alzheimer Trial

(2014) Bart De Strooper   CELL

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

CLARITY for mapping the nervous system

(2013) Kwanghun Chung et al.   NATURE METHODS

The orphan receptor GPR3 modulates the early phases of cocaine reinforcement

(2012) Clara Tourino et al.   BRITISH JOURNAL OF PHARMACOLOGY

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

(2012) Amantha Thathiah et al.   NATURE MEDICINE

Biased Ligands for Better Cardiovascular Drugs

(2011) Scott M. DeWire et al.   CIRCULATION RESEARCH

Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies

(2011) Daniah Trabzuni et al.   JOURNAL OF NEUROCHEMISTRY

GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception

(2011) Jessica Ruiz-Medina et al.   NEUROPHARMACOLOGY

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

Transgenic Mouse Models of Alzheimer's Disease

(2010) Gregory A. Elder et al.   MOUNT SINAI JOURNAL OF MEDICINE

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

 -Arrestin/Ral Signaling Regulates Lysophosphatidic Acid-Mediated Migration and Invasion of Human Breast Tumor Cells

(2009) T. T. Li et al.   MOLECULAR CANCER RESEARCH

Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance

(2009) Bing Luan et al.   NATURE

GPR3 Receptor, a Novel Actor in the Emotional-Like Responses

(2009) Olga Valverde et al.   PLoS One

The Gs-Linked Receptor GPR3 Inhibits the Proliferation of Cerebellar Granule Cells during Postnatal Development

(2009) Shigeru Tanaka et al.   PLoS One

Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease

(2009) Lisa Placanica et al.   PLoS One

The Orphan G Protein-Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

(2009) A. Thathiah et al.   SCIENCE

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

(2008) Chiho Hirata-Fukae et al.   BRAIN RESEARCH

A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

(2008) Jean-Martin Beaulieu et al.   CELL

Glucocorticoids regulate innate immunity in a model of multiple sclerosis: reciprocal interactions between the A1 adenosine receptor and β-arrestin-1 in monocytoid cells

(2007) Shigeki Tsutsui et al.   FASEB JOURNAL

Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia

(2006) E.R. Bychkov et al.   NEUROBIOLOGY OF AGING